Explore the words cloud of the ICRED project. It provides you a very rough idea of what is the project "ICRED" about.
The following table provides information about the project.
Coordinator |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Organization address contact info |
Coordinator Country | United Kingdom [UK] |
Project website | http://dixon.chem.ox.ac.uk/langui.html |
Total cost | 195˙454 € |
EC max contribution | 195˙454 € (100%) |
Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
Code Call | H2020-MSCA-IF-2015 |
Funding Scheme | MSCA-IF-EF-ST |
Starting year | 2016 |
Duration (year-month-day) | from 2016-07-11 to 2018-07-10 |
Take a look of project's partnership.
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1 | THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD | UK (OXFORD) | coordinator | 195˙454.00 |
The aim of this fellowship is to develop new reductive cyclization cascades of lactams and amides that establish these feedstock chemicals as important chemical precursors to reactive iminium ions which can be intercepted by pendant nucleophiles and exploited in carbon-carbon bond formation. A range of indole nucleophiles linked to amide and lactam functionality will be investigated for performance in the iridium catalyzed reductive cyclization cascades, and, based on successful proof of concept studies already performed in the Dixon group, a range of semi-saturated nitrogen-containing polycyclic structures possessing one or more stereocentres distributed over an architecturally complex framework should result. As well as studying diastereocontrol in the cascades, catalytic enantioselective variants will also be investigated. Finally, the application of the indole (spiro)cyclization reaction to the total synthesis of aspidospermidine will showcase the utility of the developed chemistry. This multidisciplinary Fellowship, based on high-quality and novel research at the University of Oxford, one of the top-research centres worldwide, will complement Dr Xie’s skills and knowledge to improve his career possibilities and at the same time, Dr Xie’s experience in creating catalytically active transition metal complexes will be critical for developing chiral versions of the iridium catalyst during the development of a catalytic asymmetric version of the reductive cyclization cascade.
year | authors and title | journal | last update |
---|---|---|---|
2017 |
Lan-Gui Xie, Darren J. Dixon Tertiary amine synthesis via reductive coupling of amides with Grignard reagents published pages: 7492-7497, ISSN: 2041-6520, DOI: 10.1039/c7sc03613b |
Chem. Sci. 8/11 | 2019-06-13 |
2018 |
Lan-Gui Xie and Darren J. Dixon Iridium-catalyzed reductive Ugi-type reactions of tertiary amides published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-05192-7 |
Nature Communications | 2019-06-13 |
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The information about "ICRED" are provided by the European Opendata Portal: CORDIS opendata.