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CHASSY SIGNED

Model-Based Construction And Optimisation Of Versatile Chassis Yeast Strains For Production Of Valuable Lipid And Aromatic Compounds

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

CHASSY project word cloud

Explore the words cloud of the CHASSY project. It provides you a very rough idea of what is the project "CHASSY" about.

classes platforms chassis yarrowia producing oleaginous white strategy applicable levels integrative lack cell lipid genome kluyveromyces aromatic chassy ing strains precursor factories synthetic factory host model supply marxianus base reconfigured circuits full saccharomyces oleochemicals thorough outcomes redesigning benefit networks docosanol yeast industrial limited models integrate amorfrutin biotechnology poor octanoic cerevisiae biology smes expanding molecules versatility tools yeasts species thermotolerant construction unlock proof cosmetic readily molecule sectors prototype lipolytica nutraceutical metabolic directed metabolites acid tolerance commercial restricted data compounds platform

Project "CHASSY" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK Organization address address: WESTERN ROAD city: Cork postcode: T12 YN60 website: www.ucc.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Ireland [IE]
Project website	http://www.chassy.eu
Total cost	5˙634˙610 €
EC max contribution	5˙634˙610 € (100%)
Programme	1. H2020-EU.2.1.4. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology)
Code Call	H2020-NMBP-BIO-2016
Funding Scheme	RIA
Starting year	2016
Duration (year-month-day)	from 2016-12-01 to 2020-11-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK Organization address address: WESTERN ROAD city: Cork postcode: T12 YN60 website: www.ucc.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (Cork)	coordinator	1˙216˙232.00
2	TECHNISCHE UNIVERSITEIT DELFT TECHNISCHE UNIVERSITEIT DELFT Organization address address: STEVINWEG 1 city: DELFT postcode: 2628 CN website: www.tudelft.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (DELFT)	participant	950˙091.00
3	INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT Organization address address: Rue De L'Universite 147 city: PARIS CEDEX 07 postcode: 75338 website: www.inra.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS CEDEX 07)	participant	747˙595.00
4	BIOPETROLIA AB BIOPETROLIA AB Organization address address: CHALMERS TEKNISKA HOGSKOLA city: GOTEBORG postcode: 412 96 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (GOTEBORG)	participant	702˙200.00
5	CHALMERS TEKNISKA HOEGSKOLA AB CHALMERS TEKNISKA HOEGSKOLA AB Organization address address: - city: GOETEBORG postcode: 41296 website: www.chalmers.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (GOETEBORG)	participant	652˙135.00
6	JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN Organization address address: THEODOR W ADORNO PLATZ 1 city: FRANKFURT AM MAIN postcode: 60323 website: www.uni-frankfurt.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (FRANKFURT AM MAIN)	participant	535˙500.00
7	CLARIANT PRODUKTE (DEUTSCHLAND) GMBH CLARIANT PRODUKTE (DEUTSCHLAND) GMBH Organization address address: BRUNINGSTRASSE 50 city: FRANKFURT AM MAIN postcode: 65929 website: www.clariant.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (FRANKFURT AM MAIN)	participant	367˙356.00
8	NOVA-INSTITUT FUR POLITISCHE UND OKOLOGISCHE INNOVATION GMBH NOVA-INSTITUT FUR POLITISCHE UND OKOLOGISCHE INNOVATION GMBH Organization address address: Chemiepark Knapsack Industriestrasse city: Huerth postcode: 50354 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Huerth)	participant	251˙000.00
9	UCC ACADEMY DESIGNATED ACTIVITY COMPANY UCC ACADEMY DESIGNATED ACTIVITY COMPANY Organization address address: UNIVERSITY COLLEGE CORK NATIONAL UNIVERSITY OF IRELAND WESTERN ROAD city: Cork postcode: T12 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (Cork)	participant	212˙500.00
10	EVOLVA AG EVOLVA AG Organization address address: DUGGINGERSTRASSE 23 city: REINACH postcode: 4153 website: www.evolva.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (REINACH)	participant	0.00

Map

Project objective

CHASSY will unlock the full potential of the yeasts Saccharomyces cerevisiae, Yarrowia lipolytica and Kluyveromyces marxianus as cell factories for production of high value compounds which have applications in the cosmetic, nutraceutical and white biotechnology sectors. Current cell factory strains for these classes of product are restricted to proof-of-principle levels because of limited precursor supply, poor product tolerance and lack of versatility. CHASSY addresses these challenges by redesigning metabolic circuits and expanding the host range to include the oleaginous yeast, Y. lipolytica and the thermotolerant yeast, K. marxianus. The systems biology approach will integrate model-based design, construction and analysis of yeast strains, resulting in reconfigured metabolic networks optimised for the production of lipid and aromatic molecules. Construction of the chassis strains, using new and existing synthetic biology tools, will be directed by knowledge derived from a thorough systems biology comparison of the three yeast species, conducted using integrative data analysis and genome scale metabolic models. The chassis strains will be used to build cell factories to produce three specific high value products: the oleochemicals, Docosanol and Octanoic acid; and the aromatic molecule, Amorfrutin 1. These new cell factory strains will be evaluated under industrial conditions to produce data that will further improve the chassis platforms. The major outcomes of this project will be (1) a new set of chassis yeast strains that are widely applicable for development of industrial cell factories; (2) the knowledge and technology to readily build and evaluate new chassis tailored to specific applications; (3) prototype cell factory strains producing three high value metabolites for commercial exploitation; (4) a dissemination and exploitation strategy to ensure that European SMEs benefit from the knowledge base, platform chassis and resources generated in CHASSY.

Deliverables

List of deliverables.
Library of branded publishable information (leaflets, posters, booklets, slide-set, etc.)	Documents, reports	2020-04-24 01:26:27
The CHASSY public access website up and running	Websites, patent fillings, videos etc.	2020-04-24 01:26:27
Technological fact sheets on CHASSY strains	Documents, reports	2020-04-24 01:26:28

Take a look to the deliverables list in detail: detailed list of CHASSY deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2020	Macarena Larroude, Heykel Trabelsi, Jean-Marc Nicaud, Tristan Rossignol A set of Yarrowia lipolytica CRISPR/Cas9 vectors for exploiting wild-type strain diversity published pages: , ISSN: 0141-5492, DOI: 10.1007/s10529-020-02805-4	Biotechnology Letters	2020-04-24
2020	Florian Wernig, Eckhard Boles, Mislav Oreb De novo biosynthesis of 8-hydroxyoctanoic acid via a medium-chain length specific fatty acid synthase and cytochrome P450 in Saccharomyces cerevisiae published pages: e00111, ISSN: 2214-0301, DOI: 10.1016/j.mec.2019.e00111	Metabolic Engineering Communications 10	2020-04-24
2019	Javier A. Varela, Martina Puricelli, RaÃºl A. Ortiz-Merino, Romina Giacomobono, Stephanie Braun-Galleani, Kenneth H. Wolfe, John P. Morrissey Origin of Lactose Fermentation inÂ Kluyveromyces lactisÂ by Interspecies TransferÂ of a Neo-functionalized Gene Cluster during Domestication published pages: , ISSN: 0960-9822, DOI: 10.1016/j.cub.2019.10.044	Current Biology	2020-04-24
2018	Yu, Tao; Zhou, Yongjin J.; Wenning, Leonie; Liu, Quanli; Krivoruchko, Anastasia; Siewers, Verena; Nielsen, Jens; David, Florian Author Correction: Metabolic engineering of Saccharomyces cerevisiae for production of very long chain fatty acid-derived chemicals published pages: , ISSN: 2041-1723, DOI: 10.1038/ncomms16220	Nature Communications 1	2020-04-24
2019	Else-Jasmijn Hassing, Philip A. de Groot, Vita R. Marquenie, Jack T. Pronk, Jean-Marc G. Daran Connecting central carbon and aromatic amino acid metabolisms to improve de novo 2-phenylethanol production in Saccharomyces cerevisiae published pages: 165-180, ISSN: 1096-7176, DOI: 10.1016/j.ymben.2019.09.011	Metabolic Engineering 56	2020-04-24
2019	Macarena Larroude, Youngâ€Kyoung Park, Paul Soudier, Monika Kubiak, Jeanâ€Marc Nicaud, Tristan Rossignol A modular Golden Gate toolkit for Yarrowia lipolytica synthetic biology published pages: , ISSN: 1751-7915, DOI: 10.1111/1751-7915.13427	Microbial Biotechnology	2020-04-24
2018	Yating Hu, Zhiwei Zhu, Jens Nielsen, Verena Siewers Heterologous transporter expression for improved fatty alcohol secretion in yeast published pages: 51-58, ISSN: 1096-7176, DOI: 10.1016/j.ymben.2017.11.008	Metabolic Engineering 45	2020-04-24
2017	Michal A. Åšwiat, Sofia Dashko, Maxime denÂ Ridder, Melanie Wijsman, John vanÂ derÂ Oost, Jean-Marc Daran, Pascale Daran-Lapujade FnCpf1: a novel and efficient genome editing tool for Saccharomyces cerevisiae published pages: 12585-12598, ISSN: 0305-1048, DOI: 10.1093/nar/gkx1007	Nucleic Acids Research 45/21	2020-04-24
2019	Arun S. Rajkumar, Javier A. Varela, Hannes Juergens, Jean-Marc G. Daran, John P. Morrissey Biological Parts for Kluyveromyces marxianus Synthetic Biology published pages: , ISSN: 2296-4185, DOI: 10.3389/fbioe.2019.00097	Frontiers in Bioengineering and Biotechnology 7	2020-04-24
2019	Javier A. Varela, Martina Puricelli, Noemi Montini, John P. Morrissey Expansion and Diversification of MFS Transporters in Kluyveromyces marxianus published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2018.03330	Frontiers in Microbiology 9	2020-04-24
2018	Leonie Baumann, Arun S. Rajkumar, John P. Morrissey, Eckhard Boles, Mislav Oreb A Yeast-Based Biosensor for Screening of Short- and Medium-Chain Fatty Acid Production published pages: , ISSN: 2161-5063, DOI: 10.1021/acssynbio.8b00309	ACS Synthetic Biology	2020-04-24
2018	M. Larroude, T. Rossignol, J.-M. Nicaud, R. Ledesma-Amaro Synthetic biology tools for engineering Yarrowia lipolytica published pages: , ISSN: 0734-9750, DOI: 10.1016/j.biotechadv.2018.10.004	Biotechnology Advances	2020-04-24
2018	Yongjin J. Zhou, Eduard J. Kerkhoven, Jens Nielsen Barriers and opportunities in bio-based production of hydrocarbons published pages: , ISSN: 2058-7546, DOI: 10.1038/s41560-018-0197-x	Nature Energy	2020-04-24
2017	Tao Yu, Yongjin J. Zhou, Leonie Wenning, Quanli Liu, Anastasia Krivoruchko, Verena Siewers, Jens Nielsen, Florian David Metabolic engineering of Saccharomyces cerevisiae for production of very long chain fatty acid-derived chemicals published pages: 15587, ISSN: 2041-1723, DOI: 10.1038/ncomms15587	Nature Communications 8	2020-04-24
2018	Robert Mans, Jean-Marc G Daran, Jack T Pronk Under pressure: evolutionary engineering of yeast strains for improved performance in fuels and chemicals production published pages: 47-56, ISSN: 0958-1669, DOI: 10.1016/j.copbio.2017.10.011	Current Opinion in Biotechnology 50	2020-04-24
2018	Robert Mans, Jean-Marc G Daran, Jack T Pronk Under pressure: evolutionary engineering of yeast strains for improved performance in fuels and chemicals production published pages: 47-56, ISSN: 0958-1669, DOI: 10.1016/j.copbio.2017.10.011	Current Opinion in Biotechnology 50	2020-04-24
2017	BenjamÃn J SÃ¡nchez, Cheng Zhang, Avlant Nilsson, Petriâ€Jaan Lahtvee, Eduard J Kerkhoven, Jens Nielsen Improving the phenotype predictions of a yeast genomeâ€scale metabolic model by incorporating enzymatic constraints published pages: 935, ISSN: 1744-4292, DOI: 10.15252/msb.20167411	Molecular Systems Biology 13/8	2020-04-24
2019	Hongzhong Lu, Feiran Li, BenjamÃn J. SÃ¡nchez, Zhengming Zhu, Gang Li, IvÃ¡n Domenzain, Simonas MarciÅ¡auskas, Petre Mihail Anton, Dimitra Lappa, Christian Lieven, Moritz Emanuel Beber, Nikolaus Sonnenschein, Eduard J. Kerkhoven, Jens Nielsen A consensus S. cerevisiae metabolic model Yeast8 and its ecosystem for comprehensively probing cellular metabolism published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-11581-3	Nature Communications 10/1	2020-04-24

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