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Rafts4Biotech SIGNED

Synthetic bacterial lipid rafts to optimize industrial bioprocesses

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

Rafts4Biotech project word cloud

Explore the words cloud of the Rafts4Biotech project. It provides you a very rough idea of what is the project "Rafts4Biotech" about.

discovery genome ultimately deficient undesirable toxic expertise generating biochemical synthetic multistep eukaryotic tractability performance interactions hence biotechnological remarkable metabolic industrial rafts confined bacillus raft4biotech rafts4biotech microbial mathematical stoichiometry happens engineer lipid cells biotechnologically membrane confine biosystems genetic chassis smes combines feed pharmaceutical bacteria unfavorable smcps compartments intermediates sectors released biology generation advantage reactions organize translate market faces invigorate limitations actively modeling protein coli compromise bacterial prokaryotes versatility escherichia optimized off subtilis cosmetics protect subcellular cellular species platforms rafts4biotec optimize interferences

Project "Rafts4Biotech" data sheet

The following table provides information about the project.

Coordinator	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Project website	http://rafts4biotech.eu/
Total cost	7˙484˙630 €
EC max contribution	6˙733˙580 € (90%)
Programme	1. H2020-EU.2.1.4. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology)
Code Call	H2020-NMBP-BIO-2016
Funding Scheme	RIA
Starting year	2017
Duration (year-month-day)	from 2017-01-01 to 2020-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	coordinator	1˙569˙778.00
2	GEORG-AUGUST-UNIVERSITAT GOTTINGENSTIFTUNG OFFENTLICHEN RECHTS GEORG-AUGUST-UNIVERSITAT GOTTINGENSTIFTUNG OFFENTLICHEN RECHTS Organization address address: WILHELMSPLATZ 1 city: GOTTINGEN postcode: 37073 website: http://www.uni-goettingen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (GOTTINGEN)	participant	700˙000.00
3	RIJKSUNIVERSITEIT GRONINGEN RIJKSUNIVERSITEIT GRONINGEN Organization address address: Broerstraat 5 city: GRONINGEN postcode: 9712CP website: www.rug.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (GRONINGEN)	participant	613˙706.00
4	INSTITUT PASTEUR INSTITUT PASTEUR Organization address address: RUE DU DOCTEUR ROUX 25-28 city: PARIS CEDEX 15 postcode: 75724 website: http://www.pasteur.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS CEDEX 15)	participant	600˙250.00
5	FAKULTNI NEMOCNICE U SV. ANNY V BRNE FAKULTNI NEMOCNICE U SV. ANNY V BRNE Organization address address: Pekarska 53 city: Brno postcode: 656 91 website: www.fnusa.cz contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (Brno)	participant	600˙007.00
6	BIOSYNTIA APS BIOSYNTIA APS Organization address address: KOGLE ALLE 6 city: HORSHOLM postcode: 2970 website: www.biosyntia.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (HORSHOLM)	participant	555˙250.00
7	NAICONS SRL NAICONS SRL Organization address address: VIA GUARAGNA 3 city: SARONNO VA postcode: 20147 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (SARONNO VA)	participant	555˙000.00
8	UNIVERSITATSMEDIZIN GREIFSWALD KORPERSCHAFT DES OFFENTLICHEN RECHTS UNIVERSITATSMEDIZIN GREIFSWALD KORPERSCHAFT DES OFFENTLICHEN RECHTS Organization address address: FLEISCHMANNSTRASSE 8 city: GREIFSWALD postcode: 17489 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (GREIFSWALD)	participant	446˙250.00
9	ENGENES BIOTECH GMBH ENGENES BIOTECH GMBH Organization address address: MOOSLACKENGASSE 17 city: WIEN postcode: 1190 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	434˙450.00
10	ENANTIS SRO ENANTIS SRO Organization address address: KAMENICE 771/34 city: BRNO postcode: 625 00 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (BRNO)	participant	369˙250.00
11	SCIENSEED SL SCIENSEED SL Organization address address: CALLE ARTE 3 5/A city: MADRID postcode: 28033 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	289˙637.00
12	EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Organization address address: Raemistrasse 101 city: ZUERICH postcode: 8092 website: https://www.ethz.ch/de.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ZUERICH)	participant	0.00

Map

Project objective

Genetic tractability of bacterial cells allows generating synthetic microbial chassis platforms (SMCPs) with remarkable biotechnological applications but their functionality currently faces important off-genome limitations due to deficient protein-protein interactions, unfavorable protein stoichiometry or generation of toxic intermediates that ultimately compromise the industrial production processes. To solve this problem, Rafts4Biotech project will take advantage of our recent discovery, that bacteria are able to organize subcellular membrane compartments similar to the so-called lipid rafts of eukaryotic cells, to improve/protect specific cellular processes. Rafts4Biotech project will engineer bacterial cells to confine biotechnologically relevant reactions into bacterial lipid rafts to optimize their stoichiometry and protect cells from undesirable metabolic interferences. Hence, the Rafts4Biotech project will produce new generation reliable and robust SMCPs in which industrial production processes are confined in bacterial lipid rafts, released from their classical off-genome limitations and optimized for industrial production. Moreover, this concept can be applied to many prokaryotes, since lipid rafts happens to occur in many bacterial species. Based on this versatility, Raft4Biotech project will use two biotechnologically relevant biosystems, Bacillus subtilis and Escherichia coli, to engineer synthetic bacterial lipid rafts to optimize the performance of three challenging biochemical processes in the fields of pharmaceutical, cosmetics and feed industrial sectors. To achieve this, Rafts4Biotech consortium combines different expertise in synthetic biology, systems biology and mathematical modeling and it includes a number of SMEs that will actively work in this project and will translate this technology into market application. The technology developed by Rafts4Biotec will optimize multistep industrial processes and invigorate European research.

Deliverables

List of deliverables.
Iterative loop 1	Other	2020-04-24 23:47:16
Study cases promotional material	Websites, patent fillings, videos etc.	2020-04-24 23:46:45
Description of the design of capillary microfluidic device and related software for automated control of bioreactor device	Other	2020-04-24 23:47:01
Metabolomic data analyses	Demonstrators, pilots, prototypes	2020-04-24 23:46:10
Proteomic data analyses and comparison studies	Demonstrators, pilots, prototypes	2020-04-24 23:45:55
Iterative loop 2	Other	2020-04-24 23:45:25
Transcriptomics data analyses and comparison studies	Demonstrators, pilots, prototypes	2020-04-24 23:45:41
Mid-project communication and engagement material	Websites, patent fillings, videos etc.	2020-04-24 23:46:26
Project management guideline meeting for project overall and WPs	Websites, patent fillings, videos etc.	2020-03-20 18:23:10
Initial communication material	Websites, patent fillings, videos etc.	2020-03-20 18:23:10
Presentation of Data Management Plan	Demonstrators, pilots, prototypes	2020-03-20 18:23:10
Description of the optimal design of the microfluidic chip and the related software for transforming chip data into kinetic values	Other	2020-03-20 18:23:10
Visual identity, website and social networks	Websites, patent fillings, videos etc.	2020-03-20 18:23:10

Take a look to the deliverables list in detail: detailed list of Rafts4Biotech deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2017	Daniel R. ReuÃŸ, Fabian M. Commichau, JÃ¶rg StÃ¼lke The contribution of bacterial genome engineering to sustainable development published pages: 1259-1263, ISSN: 1751-7915, DOI: 10.1111/1751-7915.12784	Microbial Biotechnology 10/5	2020-03-20
2018	Stanislav Mazurenko, Jan Stourac, Antonin Kunka, Sava NedeljkoviÄ‡, David Bednar, Zbynek Prokop, Jiri Damborsky CalFitter: a web server for analysis of protein thermal denaturation data published pages: W344-W349, ISSN: 0305-1048, DOI: 10.1093/nar/gky358	Nucleic Acids Research 46/W1	2020-03-20
2018	Lenka Sumbalova, Jan Stourac, Tomas Martinek, David Bednar, Jiri Damborsky HotSpot Wizard 3.0: web server for automated design of mutations and smart libraries based on sequence input information published pages: W356-W362, ISSN: 0305-1048, DOI: 10.1093/nar/gky417	Nucleic Acids Research 46/W1	2020-03-20
2018	Auke J vanÂ Heel, Anne deÂ Jong, Chunxu Song, Jakob H Viel, Jan Kok, Oscar P Kuipers BAGEL4: a user-friendly web server to thoroughly mine RiPPs and bacteriocins published pages: , ISSN: 0305-1048, DOI: 10.1093/nar/gky383	Nucleic Acids Research	2020-03-20
2018	Antonin Kunka, Jiri Damborsky, Zbynek Prokop Haloalkane Dehalogenases From Marine Organisms published pages: 203-251, ISSN: 0076-6879, DOI: 10.1016/bs.mie.2018.03.005	Methods in Enzymology	2020-03-20
2017	Pavel DvoÅ™Ã¡k, Pablo I. Nikel, JiÅ™Ã DamborskÃ½, VÃctor de Lorenzo Bioremediation 3 . 0 : Engineering pollutant-removing bacteria in the times of systemic biology published pages: 845-866, ISSN: 0734-9750, DOI: 10.1016/j.biotechadv.2017.08.001	Biotechnology Advances 35/7	2020-03-20

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