Explore the words cloud of the NONCODRIVERS project. It provides you a very rough idea of what is the project "NONCODRIVERS" about.
The following table provides information about the project.
Coordinator |
FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
Organization address contact info |
Coordinator Country | Spain [ES] |
Project website | http://bbglab.irbbarcelona.org |
Total cost | 1˙995˙828 € |
EC max contribution | 1˙995˙828 € (100%) |
Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
Code Call | ERC-2015-CoG |
Funding Scheme | ERC-COG |
Starting year | 2016 |
Duration (year-month-day) | from 2016-12-01 to 2021-11-30 |
Take a look of project's partnership.
# | ||||
---|---|---|---|---|
1 | FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA) | ES (BARCELONA) | coordinator | 1˙995˙828.00 |
Finding the mutations, genes and pathways directly involved in cancer is of paramount importance to understand the mechanisms of tumour development and devise therapeutic strategies to overcome the disease. Due to their role in cancer development and maintenance, the proteins encoded by cancer genes are candidate therapeutic targets. Indeed, in recent years we have witnessed the development of successful cancer-targeting therapies to counteract the effect of driver mutations. Although the coding part of the human genome has now largely been explored in the search for cancer driver mutations in most frequent cancer types, the extent of involvement of noncoding mutations in cancer development remains a mystery. The main challenges faced are: 1) the functional role of most noncoding regions is unknown, and 2) tumours often have thousands of somatic mutations, so that distinguishing cancer driver mutations from bystanders is like finding the proverbial needle in a haystack. To overcome these two challenges I propose to analyse the pattern of somatic mutations across thousands of tumours in noncoding regions to identify signals of positive selection. These signals are an indication that mutations in the region have been positively selected during tumour evolution and are thus directly involved in the tumour phenotype. The large scale analysis proposed here will allow us to create a catalogue of noncoding elements involved in different types of cancer upon mutations. We will study in detail a selected set of driver elements to uncover their specific function and role in the tumourigenic process. Furthermore, we will explore possibilities of counteracting their driver effect with targeted drugs. The results of this project may boost our understanding of the biological role of noncoding regions, help to unravel novel molecular causes of cancer and provide novel targeted therapeutic opportunities for cancer patients.
year | authors and title | journal | last update |
---|---|---|---|
2017 |
Sabarinathan R, Pich O, Martincorena I, Rubio-Perez C, Juul M, Wala J, Schumacher S, Shapira O, Sidiropoulos N, Waszak S, Tamborero D, Mularoni L, Rheinbay E, Hornshoj H, Deu-Pons J, Muinos F, Bertl J, Guo Q, Weischenfeldt J, Korbel JO, Getz G, Campbell PJ, Pedersen JS, Beroukhim R, Perez-Gonzalez A, Lopez-Bigas N, PCAWG Drivers and Functional Interpretation Group, ICGC/TCGA Pan-Cancer Analysis of The whole-genome panorama of cancer drivers published pages: , ISSN: , DOI: 10.1101/190330 |
Pre print | 2019-08-29 |
2017 |
Esther Rheinbay, Morten Muhlig Nielsen, Federico Abascal, Grace Tiao, Henrik Hornshøj, Julian M. Hess, Randi Istrup Pedersen, Lars Feuerbach, Radhakrishnan Sabarinathan, Tobias Madsen, Jaegil Kim, Loris Mularoni, Shimin Shuai, Andrés Lanzós, Carl Herrmann, Yosef E. Maruvka, Ciyue Shen, Samirkumar B. Amin, Johanna Bertl, Priyanka Dhingra, Klev Diamanti, Abel Gonzalez-Perez, Qia Discovery and characterization of coding and non-coding driver mutations in more than 2,500 whole cancer genomes published pages: , ISSN: , DOI: 10.1101/237313 |
pre print | 2019-08-29 |
2018 |
Oriol Pich, Ferran Muiños, Radhakrishnan Sabarinathan, Iker Reyes-Salazar, Abel Gonzalez-Perez, Nuria Lopez-Bigas Somatic and Germline Mutation Periodicity Follow the Orientation of the DNA Minor Groove around Nucleosomes published pages: 1074-1087.e18, ISSN: 0092-8674, DOI: 10.1016/j.cell.2018.10.004 |
Cell 175/4 | 2019-08-29 |
2018 |
Francisco MartÃnez-Jiménez, Ferran Muiños, Erika Lopez-Arribillaga, Nuria Lopez-Bigas, Abel Gonzalez-Perez Disruption of ubiquitin mediated proteolysis is a widespread mechanism of tumorigenesis published pages: , ISSN: , DOI: 10.1101/507764 |
Pre print | 2019-08-29 |
2019 |
Claudia Arnedo-Pac, Loris Mularoni, Ferran Muiños, Abel Gonzalez-Perez, Nuria Lopez-Bigas OncodriveCLUSTL: a sequence-based clustering method to identify cancer drivers published pages: , ISSN: 1367-4803, DOI: 10.1093/bioinformatics/btz501 |
Bioinformatics | 2019-09-02 |
2019 |
Abel Gonzalez-Perez, Radhakrishnan Sabarinathan, Nuria Lopez-Bigas Local Determinants of the Mutational Landscape of the Human Genome published pages: 101-114, ISSN: 0092-8674, DOI: 10.1016/j.cell.2019.02.051 |
Cell 177/1 | 2019-08-06 |
2018 |
Francisco MartÃnez-Jiménez, Ferran Muiños, Erika Lopez-Arribillaga, Nuria Lopez-Bigas, Abel Gonzalez-Perez Disruption of ubiquitin mediated proteolysis is a widespread mechanism of tumorigenesis published pages: , ISSN: , DOI: 10.1101/507764 |
Pre print | 2019-08-06 |
2018 |
David Tamborero, Carlota Rubio-Perez, Ferran Muiños, Radhakrishnan Sabarinathan, Josep M. Piulats, Aura Muntasell, Rodrigo Dienstmann, Nuria Lopez-Bigas, Abel Gonzalez-Perez A Pan-cancer Landscape of Interactions between Solid Tumors and Infiltrating Immune Cell Populations published pages: 3717-3728, ISSN: 1078-0432, DOI: 10.1158/1078-0432.ccr-17-3509 |
Clinical Cancer Research 24/15 | 2019-05-22 |
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "NONCODRIVERS" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "NONCODRIVERS" are provided by the European Opendata Portal: CORDIS opendata.