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AutismRigidPercept

Investigation and modification of atypical dynamic brain activity underlying perceptual inflexibility of autism spectrum disorders

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

AutismRigidPercept project word cloud

Explore the words cloud of the AutismRigidPercept project. It provides you a very rough idea of what is the project "AutismRigidPercept" about.

simulate bistable dynamic first individuals disorder relatively rigidity spectrum power successful landscape believe surface little basis perspective perceptual cognitive inflexibility despite integrative mechanisms symptoms fluctuating subsequently intervention underlie demonstrated core understand severe impairments protocol neural thought asd completion overlooked mitigate brain data energy fundamental explanatory calculate suitable autistic behaviours biological modify repetitive detect transition brains autism preliminary perception mental numerically empirical underlies daily evaluation tested life invasive empirically restricted

Project "AutismRigidPercept" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	https://sites.google.com/site/takamitsuwatanabesite/projects
Total cost	195˙454 €
EC max contribution	195˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2015
Duration (year-month-day)	from 2015-05-01 to 2017-07-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	195˙454.00

Map

Project objective

Perceptual and cognitive inflexibility is considered to underlie the repetitive and restricted behaviours of autism spectrum disorder (ASD). However, despite its severe effects on daily life of autistic individuals, the biological basis of these ASD core symptoms remain little known. In this project, I will investigate the neural mechanisms behind this fundamental mental inflexibility of ASD by examining neural activity during bistable perception, which is thought to be suitable for evaluation of such mental and perceptual rigidity. To detect neural responses from the brains of autistic individuals during such fluctuating perceptual experience, I will empirically calculate the energy landscape of brain activity from non-invasive measurements of brain activity and numerically simulate activity transition on the energy surface. Given the explanatory power of this method demonstrated by my preliminary data, this project is expected to provide the first empirical evidence for autistic impairments in dynamic brain activity that underlies the mental inflexibility of ASD. Furthermore, successful completion of this main project will provide insight for a novel non-invasive intervention protocol to mitigate such autistic cognitive rigidity, which will be subsequently tested within this research project. I believe that this project has the potential to provide a novel integrative perspective to understand autistic cognitive inflexibility and presents a promising approach to modify these relatively overlooked symptoms.

Publications

List of publications.
year	authors and title	journal	last update
2015	Takamitsu Watanabe, Geraint Rees Age-associated changes in rich-club organisation in autistic and neurotypical human brains published pages: , ISSN: 2045-2322, DOI: 10.1038/srep16152	Scientific Reports 5/1	2019-06-13
2017	Takamitsu Watanabe, Geraint Rees Brain network dynamics in high-functioning individuals with autism published pages: 16048, ISSN: 2041-1723, DOI: 10.1038/ncomms16048	Nature Communications 8	2019-06-13
2016	Takamitsu Watanabe, Geraint Rees Anatomical imbalance between cortical networks in autism published pages: , ISSN: 2045-2322, DOI: 10.1038/srep31114	Scientific Reports 6/1	2019-06-13
2017	Takahiro Ezaki, Takamitsu Watanabe, Masayuki Ohzeki, Naoki Masuda Energy landscape analysis of neuroimaging data published pages: 20160287, ISSN: 1364-503X, DOI: 10.1098/rsta.2016.0287	Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 375/2096	2019-06-13

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The information about "AUTISMRIGIDPERCEPT" are provided by the European Opendata Portal: CORDIS opendata.