MUC2GO SIGNED
THE ROLE OF MUCINS AND MUCUS IN THE DISEASES CYSTIC FIBROSIS, CELIAC DISEASE, AND ULCERATIVE COLITIS
Total Cost €
0EC-Contrib. €
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Explore the words cloud of the MUC2GO project. It provides you a very rough idea of what is the project "MUC2GO" about.
Project "MUC2GO" data sheet
The following table provides information about the project.
| Coordinator |
GOETEBORGS UNIVERSITET
Organization address contact info |
| Coordinator Country | Sweden [SE] |
| Project website | http://www.medkem.gu.se/mucinbiology |
| Total cost | 2˙500˙000 € |
| EC max contribution | 2˙500˙000 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2015-AdG |
| Funding Scheme | ERC-ADG |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-09-01 to 2021-08-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | GOETEBORGS UNIVERSITET | SE (GOETEBORG) | coordinator | 2˙500˙000.00 |
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Project objective
The overall aim of this proposal is to explain how the mucus systems of the intestine and lung act as a first innate immune defense line to protect our mucosal surfaces. Mucins are of highly glycosylated proteins that build the mucus skeleton. We previously discovered that there are two mucus layers in the colon. The inner mucus layer built around the MUC2 mucin is attached and impenetrable to bacteria, thus separating the intestinal bacteria from the epithelial cells. However, how the dynamic colon mucus layers are formed and controlled is poorly understood. We have established an international leading position in this research area and will now address fundamental and unresolved problems of high medical importance. The capacity of the inner mucus layer to separate bacteria from the epithelium is highly dependent on the luminal bacteria. Our results suggest specific bacteria signaling via smaller molecules or bacterial fragments to the host to increase protection. We will reveal how this signaling take place, important for understanding increased western world diseases including ulcerative colitis. Of special interest is our recent finding of a single sensory goblet cell protecting the colon crypts. We have developed a fluorescent human MUC2 transgenic mouse that is instrumental for the planned studies as well as in studies of gliadin uptake from the intestine and initiator for celiac disease. We will now transfer our leading edge knowledge of intestinal mucus structure and function to the respiratory tract. Normal trachea seems to be cleared by mucus strands formed the tracheal glands, but these strands are trapped cystic fibrosis. We will also reveal how a hypothetic attached mucus layer, as described by us in colon, could explain the mucus accumulation in chronic lung diseases. The proposed project will substantially increase our basic understanding of molecular mechanisms behind several mucus related diseases and pave the way for new treatments.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2020 |
Liisa Arike, Andrus Seiman, Sjoerd van der Post, Ana M. Rodriguez Piñeiro, Anna Ermund, André Schütte, Fredrik Bäckhed, Malin E.V. Johansson, Gunnar C. Hansson Protein Turnover in Epithelial Cells and Mucus along the Gastrointestinal Tract Is Coordinated by the Spatial Location and Microbiota published pages: 1077-1087.e3, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2019.12.068 |
Cell Reports 30/4 | 2020-03-05 |
| 2019 |
Joana K. Volk, Elisabeth E.L. Nyström, Sjoerd van der Post, Beatriz M. Abad, Bjoern O. Schroeder, Åsa Johansson, Frida Svensson, Sofia Jäverfelt, Malin E.V. Johansson, Gunnar C. Hansson, George M.H. Birchenough The Nlrp6 inflammasome is not required for baseline colonic inner mucus layer formation or function published pages: jem.20190679, ISSN: 0022-1007, DOI: 10.1084/jem.20190679 |
The Journal of Experimental Medicine | 2019-10-03 |
| 2019 |
Eran Blacher, Stavros Bashiardes, Hagit Shapiro, Daphna Rothschild, Uria Mor, Mally Dori-Bachash, Christian Kleimeyer, Claudia Moresi, Yotam Harnik, Maya Zur, Michal Zabari, Rotem Ben-Zeev Brik, Denise Kviatcovsky, Niv Zmora, Yotam Cohen, Noam Bar, Izhak Levi, Nira Amar, Tevie Mehlman, Alexander Brandis, Inbal Biton, Yael Kuperman, Michael Tsoory, Leenor Alfahel, Alon Harmelin, Michal Schwartz, Ad Potential roles of gut microbiome and metabolites in modulating ALS in mice published pages: 474-480, ISSN: 0028-0836, DOI: 10.1038/s41586-019-1443-5 |
Nature 572/7770 | 2019-10-03 |
| 2019 |
Génesis Vega, Anita Guequén, Malin E. V. Johansson, Liisa Arike, Beatriz MartÃnez-Abad, Elisabeth E. L. Nyström, Paolo Scudieri, Nicoletta Pedemonte, Pamela Millar-Büchner, Amber R. Philp, Luis J. Galietta, Gunnar C. Hansson, Carlos A. Flores Normal Calcium-Activated Anion Secretion in a Mouse Selectively Lacking TMEM16A in Intestinal Epithelium published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2019.00694 |
Frontiers in Physiology 10 | 2019-10-03 |
| 2019 |
Markus Furter, Mikael E. Sellin, Gunnar C. Hansson, Wolf-Dietrich Hardt Mucus Architecture and Near-Surface Swimming Affect Distinct Salmonella Typhimurium Infection Patterns along the Murine Intestinal Tract published pages: 2665-2678.e3, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2019.04.106 |
Cell Reports 27/9 | 2019-10-03 |
| 2019 |
Hannah Schneider, Evelin Berger, Brendan Dolan, Beatriz Martinez-Abad, Liisa Arike, Thaher Pelaseyed, Gunnar C. Hansson The human transmembrane mucin MUC17 responds to TNFα by increased presentation at the plasma membrane published pages: 2281-2295, ISSN: 0264-6021, DOI: 10.1042/bcj20190180 |
Biochemical Journal 476/16 | 2019-10-03 |
| 2017 |
Rielana Wichert, Anna Ermund, Stefanie Schmidt, Matthias Schweinlin, Miroslaw Ksiazek,Philipp Arnold,Katharina Knittler,Frederike Wilkens,1 Barbara Potempa, Bjorn Rabe, Marit Stirnberg, Ralph Lucius,Jorg W. Bartsch,Susanna Nikolaus, Maren Falk-Paulsen, Philip Rosenstiel, Marco Metzger, Stefan Rose-John,Jan Potempa, Gunnar C. Hansson, Peter J. Dempsey,and Christoph Becker-Pauly \"Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB\" published pages: 2090-2103, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2017.10.087 |
CELL Reports 21 | 2019-06-13 |
| 2018 |
Bjoern O. Schroeder, George M.H. Birchenough, Marcus Ståhlman, Liisa Arike, Malin E.V. Johansson, Gunnar C. Hansson, Fredrik Bäckhed Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration published pages: 27-40.e7, ISSN: 1931-3128, DOI: 10.1016/j.chom.2017.11.004 |
Cell Host & Microbe 23/1 | 2019-06-13 |
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