SUMCASTEC SIGNED
Semiconductor-based Ultrawideband Micromanipulation of CAncer STEm Cells
Total Cost €
0EC-Contrib. €
0Partnership
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0SUMCASTEC project word cloud
Explore the words cloud of the SUMCASTEC project. It provides you a very rough idea of what is the project "SUMCASTEC" about.
Project "SUMCASTEC" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITE DE LIMOGES
Organization address contact info |
| Coordinator Country | France [FR] |
| Project website | http://www.sumcastec.eu |
| Total cost | 3˙978˙517 € |
| EC max contribution | 3˙978˙517 € (100%) |
| Programme |
1. H2020-EU.1.2.1. (FET Open) |
| Code Call | H2020-FETOPEN-1-2016-2017 |
| Funding Scheme | RIA |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-01-01 to 2020-06-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITE DE LIMOGES | FR (Limoges) | coordinator | 994˙946.00 |
| 2 | BANGOR UNIVERSITY | UK (BANGOR) | participant | 705˙050.00 |
| 3 | AGENZIA NAZIONALE PER LE NUOVE TECNOLOGIE, L'ENERGIA E LO SVILUPPO ECONOMICO SOSTENIBILE | IT (ROMA) | participant | 690˙647.00 |
| 4 | IHP GMBH - INNOVATIONS FOR HIGH PERFORMANCE MICROELECTRONICS/LEIBNIZ-INSTITUT FUER INNOVATIVE MIKROELEKTRONIK | DE (FRANKFURT ODER) | participant | 610˙250.00 |
| 5 | CREO MEDICAL LIMITED | UK (CHEPSTOW GWENT) | participant | 530˙906.00 |
| 6 | UNIVERSITA DEGLI STUDI DI PADOVA | IT (PADOVA) | participant | 446˙717.00 |
Map
Project objective
SUMCASTEC explores radically new approach for cancer stem cells (CSCs) real time isolation (i.e. within minutes vs current 40 days) and neutralization. A novel micro-optofluidic lab-on-chip (LOC) platform will be developed through a joint and iterative effort by biologists, clinicians and engineers. For the first time, a single LOC will be capable of delivering ultra-wide broadband radiation to compare cell spectral signatures, image subcellular features, and hence modulate CSCs microenvironment conditions with unprecedented space and time resolution. It will be driven to isolate CSCs from heterogeneous differentiated and stem cell populations, and force CSCs differentiation, ultimately inducing sensitivity to anticancer treatments. Extensive in vitro and in vivo testing along with biophysical modelling will validate the approach and establish the proof-of-principle within the project life-time, while laying the groundwork for further development of future electrosurgical tools that will be capable CSCs neutralization in tissue. This will not only establish a new line of treatment for brain cancers such as Glioblastoma Multiforme and Medulloblastoma, whose initiation and recurrence were linked to CSCs, and that claim tremendous human and economic tolls, worldwide; it will also push the current boundaries of microbiological analysis by enabling microenvironment characterization/manipulation and real-time ionic channels monitoring without cytotoxic patch-clamping or electron microscopy. By investing in efforts such as SUMCASTEC’s, Europe will stand at the forefront of global biomedical innovation and push through a similar miniaturization trend as the one that propelled mobile communications, yet with much deeper societal impact. All the required competences are gathered within this consortium. The ambitious objectives of the project are planned over 42 months with a requested grant of 3 978 517,5 €.
Deliverables
| Scientific action check meeting M24 | Documents, reports | 2019-05-02 16:15:29 |
| Stakeholders management workshop | Websites, patent fillings, videos etc. | 2019-05-02 16:14:23 |
| Data Management Plan | Open Research Data Pilot | 2019-05-02 16:15:25 |
| Public Website | Websites, patent fillings, videos etc. | 2019-05-02 16:15:26 |
| List of ICT system specifications | Documents, reports | 2019-05-02 16:15:29 |
| Minutes of the Steering Committee meetings at M6 | Documents, reports | 2019-05-02 16:14:58 |
| Project identity set (logo, brochure…) | Websites, patent fillings, videos etc. | 2019-05-02 16:15:29 |
| In vitro CSCs isolation and characterization in human GBM and MB models | Documents, reports | 2019-05-02 16:15:35 |
| Minutes of the Steering Committee meetings at M12 | Documents, reports | 2019-05-02 16:15:27 |
| Minutes of the Steering Committee meeting at M18 | Documents, reports | 2019-05-02 16:14:24 |
| Biological protocols | Documents, reports | 2019-05-02 16:14:59 |
| Minutes of the Steering Committee meeting at M24 | Documents, reports | 2019-05-02 16:15:25 |
| Scientific action check meeting M12 | Documents, reports | 2019-05-02 16:14:30 |
Take a look to the deliverables list in detail: detailed list of SUMCASTEC deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2017 |
B. Cetindogan, ,M. Inac, A. Goritz, M. Wietstruck, C. Baristiran-Kaynak, C. Palego, A. Pothier, ,M. Kaynak BiCMOS Microfluidic Microwave Platform for Biological Cell Sensing and Manipulation published pages: , ISSN: , DOI: |
2017 IEEE MTT-S International Microwave Symposium (IMS) Workshop on Thermal vs non-ther | 2019-06-11 |
| 2017 |
C. Palego, C. Hancock, A. Porch, M. Kaynak BiCMOS/microfluidics lab-on-chip published pages: , ISSN: , DOI: |
2017 Engineering Wales Conference | 2019-06-11 |
| 2017 |
C. Hancock Advanced RF, Microwave and Millimeter Wave Energy Based Systemsto Address A Range of Unmet and Growing Clinical Needs published pages: , ISSN: , DOI: |
2017 Workshop IEEE MTT-S International Microwave Symposium (IMS) Workshop on Thermal vs non-ther | 2019-06-11 |
| 2017 |
A. Pothier, C.Dalmay, F. Hjeij P. Blondy, F.Lalloué, B.Bessette, M.Kaynak, C. Palego Dielectric Spectroscopy and RF and Microwave Passive Microsystems for Biological Applications and Discrimination of Cells published pages: , ISSN: , DOI: |
2017 IEEE MTT-S International Microwave Symposium (IMS) | 2019-06-11 |
| 2019 |
I. V. Minin, O. V. Minin, G. M. Katyba, N. V. Chernomyrdin, V. N. Kurlov, K. I. Zaytsev, L. Yue, Z. Wang, D. N. Christodoulides Experimental observation of a photonic hook published pages: 31105, ISSN: 0003-6951, DOI: 10.1063/1.5065899 |
Applied Physics Letters 114/3 | 2019-05-23 |
| 2018 |
Gamal, Wesam; Pinto, Rosanna; Tanori, Mirella; Casciati, Arianna; Mancuso, Mariateresa; Persano, Luca; Viola, Giampietro; Saada, Sofiane; Bessette, Barbara; Lalloue, Fabrice; Pothier, Arnaud; Palego, Cristiano; Merla, Caterina Permittivity measurements of brain cancer cell solutions: towards the electric characterisation of single cancer stem cells, 1st EMF-Med World Conference on Biomedical Applications published pages: , ISSN: , DOI: 10.5281/zenodo.1443523 |
2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med) | 2019-05-23 |
| 2018 |
C. Palego Tiny chips: from bee wearable electronics to cancer stem cells seek and destroy published pages: , ISSN: , DOI: |
2018 Center for High Frequency Electronics Seminar | 2019-03-11 |
| 2018 |
S. Saada , R. Manczak, B. Bessette, G.Begaud, C. Dalmay, S. Battu,P.Blondy, M. Inac, C. Baristiran Kaynak, M. Kaynak, C.Palego, M.0 Jauberteau, A. Pothier, F.Lalloue Discrimination of Glioblastoma Cancer Stem Cells by their UHF-Dielectrophoresis Crossover Frequency published pages: , ISSN: , DOI: |
2018 International Conference on Cancer Stem Cells and Oncology Research | 2019-03-11 |
| 2018 |
S Saada Isolation and characterization of the Cancer Stem cells (CSCs): one question, many answers published pages: , ISSN: , DOI: |
2018 Workshop on EM field interaction with biological tissues for cancer and regenerative medicine | 2019-03-11 |
| 2018 |
G. Begaud; B. Bessette; S. Saad; R. Manczak; M. Mancuso; F. Lalloue; C. Dalmay; A Pothier; P.J.P. Cardot; S. Battu Strategy for brain stem cell sorting with SDFF published pages: , ISSN: , DOI: |
2018 International Symposium on Field and Flow Based Separations | 2019-03-11 |
| 2018 |
R Manzac, A Pothier. C. Dalamy, P. Blondy, S. Saada, F. Lalloue On-chip Flow Cell Sorting System Based on High frequency Dielectrophoresis implemented on CMOS technology published pages: , ISSN: , DOI: |
2018 Workshop of GDR Micronanofluidics | 2019-03-12 |
| 2018 |
S. Saada , R. Manczak, B. Bessette, G.Begaud, C. Dalmay, S. Battu,P.Blondy, M. Inac, C. Baristiran Kaynak, M. Kaynak, C.Palego, M.0 Jauberteau, A. Pothier, F.Lalloue Glioblastoma Cancer Stem like Cells discrimination by UHF-Dielectrophoresis Crossover Frequency published pages: , ISSN: , DOI: |
2018 Workshop of French Canceropole GSO | 2019-03-11 |
| 2018 |
I. Davies Electro-permeabilization of isolated cancer stem cells with a push-pull configuration of high power MOSFETs published pages: , ISSN: , DOI: |
2018 Workshop on EM field interaction with biological tissues for cancer and regenerative medicine | 2019-03-12 |
| 2018 |
W Ramal Dielectric characterization of brain cancer cell lines published pages: , ISSN: , DOI: |
2018 Workshop on EM field interaction with biological tissues for cancer and regenerative medicine | 2019-03-11 |
| 2019 |
T. Provent, R. Manczak, S. Saada, C.Dalmay, B. Bessette, P. Blondy, G. Begaud, S. Battu, M.O. Jauberteau, F. Lalloué, A. Pothier Ultra-High Frequencies continuous biological cell sorting based on repulsive and low dielectrophoresis forces, published pages: , ISSN: , DOI: |
2019 IEEE MTT-S International Microwave Symposium (IMS) | 2019-03-11 |
| 2019 |
Mirella Tanori, Arianna Casciati, Barbara Tanno, Paola Giardullo, Alessandro Zambotti, Carmela Marino, Caterina Merla, Mariateresa Mancuso New therapeutic strategy for medulloblastoma: µs pulse electric fields exposure targeting cancer stem cells to promote radiosensitization published pages: , ISSN: , DOI: |
2019 International Conference on Radiation in Various Fields of Research (RAD 2019) | 2019-03-11 |
| 2018 |
C. Merla Novel and versatile instrumentation for electro-manipulation of cancer stem cells published pages: , ISSN: , DOI: |
2018 BioEM 2018 The Joint Annual Meeting of The Bioelectromagnetics Society and the European BioElectromagnetics Association | 2019-03-12 |
| 2018 |
C. Merla Ultra-short pulsed electric fields: a first study on cancer stem cells published pages: , ISSN: , DOI: |
2018 Workshop on EM field interaction with biological tissues for cancer and regenerative medicine | 2019-03-11 |
| 2018 |
A Pothier BiCMOS integrated microfluidic cell sorting platform for CSC cell study published pages: , ISSN: , DOI: |
2018 Workshop on EM field interaction with biological tissues for cancer and regenerative medicine | 2019-03-11 |
| 2018 |
A. Pothier Detection and Neutralization of Cancerous Stem Cells with lab on chip published pages: , ISSN: , DOI: |
2018 Workshop of GDR Happybio 06-08 November 201 | 2019-03-12 |
| 2019 |
Remi Manczak, Sofiane Saada, Thomas Provent, Claire Dalmay, Barbara Bessette, Gaelle Begaud, Serge Battu, Pierre Blondy, Marie-Odile Jauberteau, Canan Baristiran Kaynak, Mehmet Kaynak, Cristiano Palego, Fabrice Lalloue, Arnaud Pothier UHF-Dielectrophoresis Crossover Frequency as a New Marker for Discrimination of Glioblastoma Undifferentiated Cells published pages: 1-1, ISSN: 2469-7249, DOI: 10.1109/jerm.2019.2895539 |
IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology | 2019-03-11 |
| 2018 |
Gamal, Wesam; Pinto, Rosanna; Tanori, Mirella; Casciati, Arianna; Mancuso, Mariateresa; Persano, Luca; Viola, Giampietro; Saada, Sofiane; Bessette, Barbara; Lalloue, Fabrice; Pothier, Arnaud; Palego, Cristiano; Merla, Caterina Permittivity measurements of brain cancer cell solutions: towards the electric characterisation of single cancer stem cells, 1st EMF-Med World Conference on Biomedical Applications published pages: , ISSN: , DOI: 10.5281/zenodo.1443523 |
2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med) | 2019-02-27 |
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