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ByAxon SIGNED

Towards an active bypass for neural reconnection

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

ByAxon project word cloud

Explore the words cloud of the ByAxon project. It provides you a very rough idea of what is the project "ByAxon" about.

independent magnetoencephalography spinal something drawbacks retinal room lack deep nanowire fes devoted electric interfacing detect neuromedicine comprising scientists techniques restoring sensors complementary primary materials contact interdisciplinary muscular active nanotechnology cord adhesion magnetoresistance feedback cryogenic electronic magnetic detecting functional acting efficiency generation sc coatings ultimate cables temperature hence bypass nanostructured breakthroughs perspective resolution offers temperatures clinicians promises electrical regenerative experts injured portable material potentials stimulation electrodes outcomes biologists local byaxon enhanced transmission pulses interface tackling sensing specially signals neural sensory implant levels prototype implants brain pursuit

Project "ByAxon" data sheet

The following table provides information about the project.

Coordinator	FUNDACION IMDEA NANOCIENCIA Organization address address: CIUDAD UNIVERSITARIA DE CANTOBLANCO - CALLE FARADAY 9 city: MADRID postcode: 28049 website: http://www.nanociencia.imdea.org/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Project website	http://byaxon-project.eu/
Total cost	3˙752˙057 €
EC max contribution	3˙752˙057 € (100%)
Programme	1. H2020-EU.1.2.1. (FET Open)
Code Call	H2020-FETOPEN-1-2016-2017
Funding Scheme	RIA
Starting year	2017
Duration (year-month-day)	from 2017-01-01 to 2020-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FUNDACION IMDEA NANOCIENCIA FUNDACION IMDEA NANOCIENCIA Organization address address: CIUDAD UNIVERSITARIA DE CANTOBLANCO - CALLE FARADAY 9 city: MADRID postcode: 28049 website: http://www.nanociencia.imdea.org/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	coordinator	1˙212˙500.00
2	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	1˙161˙903.00
3	SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI DI TRIESTE SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI DI TRIESTE Organization address address: VIA BONOMEA 265 city: TRIESTE postcode: 34136 website: www.sissa.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (TRIESTE)	participant	636˙960.00
4	Mfd-diagnostics GmbH Mfd-diagnostics GmbH Organization address address: Mikroforum Ring 2 city: Wendelsheim postcode: 55234 website: www.mfd-diagnostics.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Wendelsheim)	participant	287˙500.00
5	SERVICIO DE SALUD DE CASTILLA LA MANCHA SERVICIO DE SALUD DE CASTILLA LA MANCHA Organization address address: AVENIDA RIO GUADIANA 4 city: TOLEDO postcode: 45007 website: http://sescam.jccm.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (TOLEDO)	participant	243˙569.00
6	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	209˙624.00

Map

Project objective

ByAxon is devoted to the development of a new generation of sensors and electrodes based on nanotechnology materials for neural interfacing. We aim to design and build a prototype of an active implant that could work directly at the spinal cord (SC) level. This implant will be primary focused on restoring the transmission of electrical signals in the injured SC, acting as an active local bypass, something not possible with current technology. Further applications might include deep brain stimulation or retinal implants, among others. Current neural interfacing approaches are based on detecting electric potentials at the brain level, and/or triggering functional electrical stimulation (FES) through electrodes at muscular or SC levels. Important present drawbacks are the large number of cables and electrodes they require and, specially, the lack of sensory feedback. The ultimate non-contact sensing devices (magnetoencephalography) detect magnetic-field pulses generated by potentials at the brain, but require cryogenic temperatures, and, hence, are not portable. We will exploit here the enhanced properties of nanostructured materials to develop improved room temperature magnetoresistance-based high-resolution magnetic sensors. This will allow tackling not only the brain but also the SC directly. We pursuit a novel integrated interface comprising both sensing and stimulation at the SC level. To reach this aim, we will develop FES electrodes of enhanced adhesion and efficiency by using nanowire coatings. ByAxon is supported by an interdisciplinary consortium, going from material scientists and electronic experts to biologists and clinicians. Our nanotechnology-based approach offers a novel perspective and will be complementary to, but independent from, present neural regenerative techniques. Our technology promises significant outcomes towards the development of an active local bypass and it has the potential to provide much-needed breakthroughs in future neuromedicine.

Deliverables

List of deliverables.
Dissemination and Exploitation Plan	Documents, reports	2019-06-06 16:04:37
Report on electrophysiological tests 2	Documents, reports	2019-06-06 16:04:30
Report on the magnetic sensor and nanostructured electrode development	Documents, reports	2019-05-24 11:49:59
Functional artificial neuron	Demonstrators, pilots, prototypes	2019-05-24 11:49:52
First nanostructured electrode	Demonstrators, pilots, prototypes	2019-05-24 11:49:54
Social network sites	Websites, patent fillings, videos etc.	2019-05-24 11:49:49
First four-bridge magnetic sensor	Demonstrators, pilots, prototypes	2019-05-24 11:49:53
Website and project logo	Websites, patent fillings, videos etc.	2019-05-24 11:50:01
First nanostructured electrode on neuron-accesible substrates	Demonstrators, pilots, prototypes	2019-05-24 11:49:59
Public report on biocompatibility in vitro 1	Documents, reports	2019-05-24 11:49:49

Take a look to the deliverables list in detail: detailed list of ByAxon deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2017	Ankor GonzÃ¡lez-Mayorga, Elisa LÃ³pez-Dolado, MarÃa C. GutiÃ©rrez, Jorge E. Collazos-Castro, M. Luisa Ferrer, Francisco del Monte, MarÃa C. Serrano Favorable Biological Responses of Neural Cells and Tissue Interacting with Graphene Oxide Microfibers published pages: 8253-8263, ISSN: 2470-1343, DOI: 10.1021/acsomega.7b01354	ACS Omega 2/11	2019-06-11
2017	Olivier Rousseau, StÃ©phane Flament, Bruno Guillet, Marc Lam Chok Sing, Laurence MÃ©chin Magnetic Sensors Based on AMR Effect in LSMO Thin Films published pages: 635, ISSN: 2504-3900, DOI: 10.3390/proceedings1040635	Proceedings 1/4	2019-06-11
2018	Emily R. Aurand, Sadaf Usmani, Manuela Medelin, Denis Scaini, Susanna Bosi, Federica B. Rosselli, Sandro Donato, Giuliana Tromba, Maurizio Prato, Laura Ballerini Nanostructures to Engineer 3D Neural-Interfaces: Directing Axonal Navigation toward Successful Bridging of Spinal Segments published pages: 1700550, ISSN: 1616-301X, DOI: 10.1002/adfm.201700550	Advanced Functional Materials 28/12	2019-06-11
2017	Paolo Perna, Davide Maccariello, Fernando Ajejas, Ruben Guerrero, Laurence MÃ©chin, Stephane Flament, Jacobo Santamaria, Rodolfo Miranda, Julio Camarero Engineering Large Anisotropic Magnetoresistance in La 0.7 Sr 0.3 MnO 3 Films at Room Temperature published pages: 1700664, ISSN: 1616-301X, DOI: 10.1002/adfm.201700664	Advanced Functional Materials 27/26	2019-06-11
2018	Sandeep Kumar Chaluvadi, Fernando Ajejas, Pasquale Orgiani, Olivier Rousseau, Giovanni Vinai, Aleksandr Yu Petrov, Piero Torelli, Alain Pautrat, Julio Camarero, Paolo Perna, Laurence Mechin Room temperature biaxial magnetic anisotropy in La 0.67 Sr 0.33 MnO 3 thin films on SrTiO 3 buffered MgO (001) substrates for spintronic applications published pages: 52403, ISSN: 0003-6951, DOI: 10.1063/1.5020072	Applied Physics Letters 113/5	2019-05-15

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The information about "BYAXON" are provided by the European Opendata Portal: CORDIS opendata.