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PDZnet SIGNED

Unraveling Principles of PDZ-mediated Cell Signaling

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

PDZnet project word cloud

Explore the words cloud of the PDZnet project. It provides you a very rough idea of what is the project "PDZnet" about.

conceptually beneficiaries central chemical transporters complementary multidisciplinary innovation signaling science combination committed ion encompasses effort millions plethora integrating platform frontline assemblies pertinent protein organizing live discovering transmitted educational membrane opportunity outstanding innovative transferable stage students training channels disciplines create industrial drug interdisciplinary pdznet interactions reputed doctoral pdz network emphasis animals cell receive networks lipid intracellular mediated recognizing unraveling interactomes cancer diseases scientific play trafficking nodes domain europeans brain academic phd domains modules societal skills nervous transduction leaders therapies receptors life inhibitors signal intersectoral diverse thereby

Project "PDZnet" data sheet

The following table provides information about the project.

Coordinator	KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Denmark [DK]
Project website	http://pdznet.eu/
Total cost	3˙733˙514 €
EC max contribution	3˙733˙514 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2015
Funding Scheme	MSCA-ITN-ETN
Starting year	2016
Duration (year-month-day)	from 2016-09-01 to 2020-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KOBENHAVNS UNIVERSITET KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	coordinator	580˙163.00
2	NOVO NORDISK A/S NOVO NORDISK A/S Organization address address: NOVO ALLE 1 city: BAGSVAERD postcode: 2880 website: www.novonordisk.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (BAGSVAERD)	participant	580˙163.00
3	UPPSALA UNIVERSITET UPPSALA UNIVERSITET Organization address address: VON KRAEMERS ALLE 4 city: UPPSALA postcode: 751 05 website: www.uu.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (UPPSALA)	participant	527˙318.00
4	SYSTASY BIOSCIENCE GMBH SYSTASY BIOSCIENCE GMBH Organization address address: BALANSTR. 6 city: MUNCHEN postcode: 81669 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUNCHEN)	participant	456˙204.00
5	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	307˙418.00
6	CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE Organization address address: Rue Laurent Fries 1 city: ILLKIRCH GRAFFENSTADEN postcode: 67404 website: www.igbmc.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (ILLKIRCH GRAFFENSTADEN)	participant	262˙875.00
7	INSTITUT PASTEUR INSTITUT PASTEUR Organization address address: RUE DU DOCTEUR ROUX 25-28 city: PARIS CEDEX 15 postcode: 75724 website: http://www.pasteur.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS CEDEX 15)	participant	262˙875.00
8	UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA Organization address address: Piazzale Aldo Moro 5 city: ROMA postcode: 185 website: www.uniroma1.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	participant	258˙061.00
9	EUROPEAN MOLECULAR BIOLOGY LABORATORY EUROPEAN MOLECULAR BIOLOGY LABORATORY Organization address address: Meyerhofstrasse 1 city: HEIDELBERG postcode: 69117 website: http://www.embl.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	participant	249˙216.00
10	JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN Organization address address: THEODOR W ADORNO PLATZ 1 city: FRANKFURT AM MAIN postcode: 60323 website: www.uni-frankfurt.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (FRANKFURT AM MAIN)	participant	249˙216.00

Map

Project objective

PDZnet will create an innovative European PhD training network focusing on unraveling PDZ domain-mediated signaling networks. The emphasis will be on signaling nodes essential for the development of cancer and diseases of the nervous system, conditions that affect millions of Europeans and are major societal challenges. PDZ domains are protein and lipid recognizing modules that play a central role in trafficking and organizing diverse cell signaling assemblies, thereby allowing information to be transmitted from receptors, ion channels and transporters in the cell membrane. PDZ domain mediated interactions are emerging as conceptually novel and promising drug targets, with exciting opportunities for the development of novel therapies, especially within cancer and brain diseases. We will establish a European multidisciplinary platform integrating a plethora of complementary life science disciplines that range from chemical development of inhibitors to studies in live animals. The network encompasses 8 academic and 2 industrial beneficiaries as well as one industrial and one academic partner, which are all committed to promote frontline research, innovation and educational activities within the study of PDZ domain-mediated signal transduction pathways related to brain diseases and cancer. This interdisciplinary network will establish an outstanding training opportunity for Early Stage Researchers, who will be integrated in projects unraveling intracellular PDZ domain interactomes to provide pertinent information for discovering drug-related interactions. In a comprehensive and integrated training effort, involving a combination of scientific and transferable skills, the students will receive an interdisciplinary, intersectoral and innovative doctoral training from experienced industrial and academic leaders in well-reputed European Institutions.

Deliverables

List of deliverables.
CDE plan	Documents, reports	2020-03-20 16:08:19
PDZnet website	Websites, patent fillings, videos etc.	2020-03-20 16:08:19

Take a look to the deliverables list in detail: detailed list of PDZnet deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Antonio Coluccia, Giuseppe La Regina, Valentina Naccarato, Marianna Nalli, Viviana Orlando, Stefano Biagioni, Maria Laura De Angelis, Marta Baiocchi, Candice Gautier, Stefano Gianni, Fiorella Di Pastena, Laura Di Magno, Gianluca Canettieri, Addolorata Maria Luce Coluccia, Romano Silvestri Drug Design and Synthesis of First in Class PDZ1 Targeting NHERF1 Inhibitors as Anticancer Agents published pages: , ISSN: 1948-5875, DOI: 10.1021/acsmedchemlett.8b00532	ACS Medicinal Chemistry Letters	2020-03-20
2016	Muna L Hilal, MaitÃ© M Moreau, Claudia Racca, Vera L Pinheiro, Nicolas H Piguel, Marie-JosÃ©e Santoni, Steve Dos Santos Carvalho, Jean-Michel Blanc, Yah-Se K Abada, Ronan Peyroutou, Chantal Medina, HÃ©lÃ¨ne Doat, Thomas Papouin, Laurent Vuillard, Jean-Paul Borg, Rivka Rachel, Aude Panatier, Mireille Montcouquiol, StÃ©phane H R Oliet, Nathalie Sans Activity-Dependent Neuroplasticity Induced by an Enriched Environment Reverses Cognitive Deficits in Scribble Deficient Mouse published pages: 5635-5651, ISSN: 1047-3211, DOI: 10.1093/cercor/bhw333	Cerebral Cortex 27/12	2020-03-20
2018	Candice Gautier, Louise Laursen, Per Jemth, Stefano Gianni Seeking allosteric networks in PDZ domains published pages: , ISSN: 1741-0126, DOI: 10.1093/protein/gzy033	Protein Engineering, Design and Selection	2020-03-20
2017	Eric Bailly, Alexandra Walton, Jean-Paul Borg The planar cell polarity Vangl2 protein: From genetics to cellular and molecular functions published pages: , ISSN: 1084-9521, DOI: 10.1016/j.semcdb.2017.10.030	Seminars in Cell & Developmental Biology	2020-03-20
2017	Tianliang Sun, Lida Yang, Harmandeep Kaur, Jenny Pestel, Mario Looso, Hendrik Nolte, Cornelius Krasel, Daniel Heil, Ramesh K. Krishnan, Marie-JosÃ©e Santoni, Jean-Paul Borg, Moritz BÃ¼nemann, Stefan Offermanns, Jakub M. Swiercz, Thomas Worzfeld A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib published pages: 199-215, ISSN: 0021-9525, DOI: 10.1083/jcb.201602002	The Journal of Cell Biology 216/1	2020-03-20
2018	Madeline N. Hayes, Karin McCarthy, Alexander Jin, Mariana L. Oliveira, Sowmya Iyer, Sara P. Garcia, Sivasish Sindiri, Berkley Gryder, Zainab Motala, G. Petur Nielsen, Jean-Paul Borg, Matt van de Rijn, David Malkin, Javed Khan, Myron S. Ignatius, David M. Langenau Vangl2/RhoA Signaling Pathway Regulates Stem Cell Self-Renewal Programs and Growth in Rhabdomyosarcoma published pages: 414-427.e6, ISSN: 1934-5909, DOI: 10.1016/j.stem.2018.02.002	Cell Stem Cell 22/3	2020-03-20
2018	Laura Polivka, Smail Hadj-Rabia, Elodie Bal, StÃ©phanie Leclerc-Mercier, Marine Madrange, Yamina Hamel, Damien Bonnet, StÃ©phanie Mallet, Hubert Lepidi, Caroline Ovaert, Patrick Barbet, Christophe Dupont, BÃ©nÃ©dicte Neven, Arnold Munnich, Lisa M. Godsel, Florence Campeotto, Robert Weil, Emmanuel Laplantine, Sylvie Marchetto, Jean-Paul Borg, William I. Weis, Jean-Laurent Casanova, Anne Puel, Kathl Epithelial barrier dysfunction in desmoglein-1 deficiency published pages: , ISSN: 0091-6749, DOI: 10.1016/j.jaci.2018.04.007	Journal of Allergy and Clinical Immunology	2020-03-20
2017	Amandine Cartier-Michaud, Anne-Laure Bailly, StÃ©phane Betzi, Xiaoli Shi, Jean-Claude Lissitzky, Ana Zarubica, Arnauld SergÃ©, Philippe Roche, Adrien Lugari, VÃ©ronique Hamon, Florence Bardin, Carine Derviaux, FrÃ©dÃ©rique Lembo, StÃ©phane Audebert, Sylvie Marchetto, BÃ©nÃ©dicte Durand, Jean-Paul Borg, Ning Shi, Xavier Morelli, Michel Aurrand-Lions Genetic, structural, and chemical insights into the dual function of GRASP55 in germ cell Golgi remodeling and JAM-C polarized localization during spermatogenesis published pages: e1006803, ISSN: 1549-1277, DOI: 10.1371/journal.pgen.1006803	PLOS Genetics 13/6	2020-03-20
2017	Candice Gautier, Lorenzo Visconti, Per Jemth, Stefano Gianni Addressing the role of the Î±-helical extension in the folding of the third PDZ domain from PSD-95 published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-12827-0	Scientific Reports 7/1	2020-03-20
2018	Jia Yuan, Wenbo Deng, Jeeyeon Cha, Xiaofei Sun, Jean-Paul Borg, Sudhansu. K. Dey Tridimensional visualization reveals direct communication between the embryo and glands critical for implantation published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03092-4	Nature Communications 9/1	2020-03-20
2017	Avais M. Daulat, Jean-Paul Borg Wnt/Planar Cell Polarity Signaling: New Opportunities for Cancer Treatment published pages: 113-125, ISSN: 2405-8033, DOI: 10.1016/j.trecan.2017.01.001	Trends in Cancer 3/2	2020-03-20
2018	Concetta Saponaro, Sara Sergio, Antonio Coluccia, Maria De Luca, Giuseppe La Regina, Luca Mologni, Valeria Famiglini, Valentina Naccarato, Daniela Bonetti, Candice Gautier, Stefano Gianni, Daniele Vergara, Michel Salzet, Isabelle Fournier, Cecilia Bucci, Romano Silvestri, Carlo Gambacorti Passerini, Michele Maffia, Addolorata Maria Luce Coluccia Î²-catenin knockdown promotes NHERF1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy published pages: 3301-3316, ISSN: 0950-9232, DOI: 10.1038/s41388-018-0170-y	Oncogene 37/24	2020-03-20
2019	Antonio Coluccia, Giuseppe La Regina, Valentina Naccarato, Marianna Nalli, Viviana Orlando, Stefano Biagioni, Maria Laura De Angelis, Marta Baiocchi, Candice Gautier, Stefano Gianni, Fiorella Di Pastena, Laura Di Magno, Gianluca Canettieri, Addolorata Maria Luce Coluccia, Romano Silvestri Drug Design and Synthesis of First in Class PDZ1 Targeting NHERF1 Inhibitors as Anticancer Agents published pages: , ISSN: 1948-5875, DOI: 10.1021/acsmedchemlett.8b00532	ACS Medicinal Chemistry Letters	2020-03-20

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