One-Flow SIGNED
Catalyst Cascade Reactions in ‘One-Flow’ within a Compartmentalized, Green-Solvent ‘Digital Synthesis Machinery’ – End-to-End Green Process Design for Pharmaceuticals
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0One-Flow project word cloud
Explore the words cloud of the One-Flow project. It provides you a very rough idea of what is the project "One-Flow" about.
Project "One-Flow" data sheet
The following table provides information about the project.
| Coordinator |
TECHNISCHE UNIVERSITEIT EINDHOVEN
Organization address contact info |
| Coordinator Country | Netherlands [NL] |
| Project website | https://one-flow.org/ |
| Total cost | 3˙896˙827 € |
| EC max contribution | 3˙896˙827 € (100%) |
| Programme |
1. H2020-EU.1.2.1. (FET Open) |
| Code Call | H2020-FETOPEN-1-2016-2017 |
| Funding Scheme | RIA |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-01-01 to 2020-12-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | TECHNISCHE UNIVERSITEIT EINDHOVEN | NL (EINDHOVEN) | coordinator | 1˙197˙023.00 |
| 2 | TECHNISCHE UNIVERSITEIT DELFT | NL (DELFT) | participant | 482˙690.00 |
| 3 | TECHNISCHE UNIVERSITAET GRAZ | AT (GRAZ) | participant | 404˙940.00 |
| 4 | UNIVERSITAET BIELEFELD | DE (BIELEFELD) | participant | 401˙750.00 |
| 5 | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS | FR (PARIS) | participant | 359˙001.00 |
| 6 | MICROINNOVA ENGINEERING GMBH | AT (ALLERHEILIGEN BEI WILDON) | participant | 356˙750.00 |
| 7 | THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE | UK (CAMBRIDGE) | participant | 350˙000.00 |
| 8 | UNIVERSITY OF HULL | UK (HULL) | participant | 344˙672.00 |
Map
Project objective
'ONE-FLOW translates ‘vertical hierarchy’ of chemical multistep synthesis with its complex machinery into self-organising ‘horizontal hierarchy’ of a compartmentalized flow reactor system – a biomimetic digital flow cascade machinery with just one reactor passage. To keep horizontal hierarchy manageable, orthogonality among the consecutive reactions needs to be increased. The winning point of nature is to have invented catalytic cascades. ONE-FLOW will uplift that by enabling the best bio- and chemocatalysts working hand in hand. 4 synthetic flow cascades ('metabolic pathways’) and 1 flow cascade driven by automated intelligence ('signaling pathway') will produce 4 Top-list 2020 drugs. ‘The Compartmentalized Smart Factory’ will develop organic, inorganic, and mechanical compartmentalization. ‘The Green-Solvent Spaciant Factory’ will fluidically allow the use of interim reaction spaces (spaciants). ‘The Systemic Operations Factory’ will aim at full orthogonality using data-base guided ultimate process harmonization. ‘The Digital Machine-to-Machine Factory’ will alter the landscape of chemical synthesis by virtue of the 'Internet of Chemical Things'. Automated machine-to-machine data transfer enables relegation of process monitoring to central computer systems under the oversight of chemists. ‘The Fully Continuous Integrated Factory’ will develop a commercial platform technology under the auspices of sustainability-driven process-design evaluation, making amenable the new kind of processing to all chemists. ONE-FLOW has massive impact potential: i) 38 billion Euro production cost saving; ii) 300 million EUR cost saving per drug; iii) address diseases with 500 billion Euro medication costs; iv) increase market share of emerging high-tech SME players by 10% in 10 years; v) open new windows of opportunity (personalized medicine) with 200-500 million Euro per disease; and vi) achieve 40% female share on a senior scientist level (ONE-FLOW: 34% senior, 57% junior).'
Deliverables
| Cascade 3 - b) synthesis of Sacubitril | Documents, reports | 2020-04-16 13:41:05 |
| Exploiting iterative reactivity of boronic acids via flow generated reactive intermediates | Documents, reports | 2020-04-16 13:42:09 |
| Polymersome-based improvement of cascade 1: a) harmonization of catalyst & solvent | Documents, reports | 2020-04-16 13:42:45 |
| Cascade 1 - synthesis of cannabinoid derivatives | Documents, reports | 2020-04-16 13:42:38 |
| Periodic report action check meeting 2 | Documents, reports | 2020-04-16 13:42:31 |
| Development of a critical process parameter map | Documents, reports | 2020-04-16 13:42:24 |
| A new generic microcontroller remote command and control device for chemical reactions in flow | Documents, reports | 2020-04-16 13:42:03 |
| Application of the systemic operation factory in cascade 4 | Documents, reports | 2020-04-16 13:41:56 |
| Data acquisition | Documents, reports | 2020-04-16 13:41:43 |
| Shifting the epimerization equilibrium of cascade 2 | Documents, reports | 2020-04-16 13:41:36 |
| Spaciant-based solvent dispersion and unification for cascade 4 | Documents, reports | 2020-04-16 13:41:30 |
| Application of the microcontroller in cascade 1 | Documents, reports | 2020-04-16 13:42:17 |
| Criteria definition and orthogonality decision execution | Documents, reports | 2020-04-16 13:41:50 |
| Catalyst slurries in multi-phase micro-flows | Documents, reports | 2020-04-16 13:41:23 |
| Cascade 4 - Synthesis of Capecitabine | Documents, reports | 2020-04-16 13:41:17 |
| Enable a co-catalyst flow operation for cascade 3 | Documents, reports | 2020-04-16 13:41:11 |
| Cascade 2 - synthesis of ursodeoxycholic acid | Documents, reports | 2020-04-16 13:42:54 |
| Cascade 3 – a) synthesis of Valsartan | Documents, reports | 2020-01-20 16:19:30 |
| Technical action check meeting 1 | Documents, reports | 2020-01-20 16:19:30 |
| Data Management Plan | Open Research Data Pilot | 2020-01-20 16:19:30 |
| Project webpage and logo | Websites, patent fillings, videos etc. | 2020-01-20 16:19:29 |
Take a look to the deliverables list in detail: detailed list of One-Flow deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Katharina Hiebler, Carina Dertnig, Sebastian Soritz, Manuel C. Maier, Theresa R. Hörmann, Bianca Grabner, Heidrun Gruber-Woelfler Development of a multistep reaction cascade for the synthesis of a sacubitril precursor in continuous flow published pages: , ISSN: 2062-249X, DOI: 10.1007/s41981-019-00058-5 |
Journal of Flow Chemistry | 2020-03-06 |
| 2019 |
Ana Maria Bago Rodriguez, Bernard P. Binks Capsules from Pickering emulsion templates published pages: 107-129, ISSN: 1359-0294, DOI: 10.1016/j.cocis.2019.09.006 |
Current Opinion in Colloid & Interface Science 44 | 2020-03-06 |
| 2018 |
Fabio Tonin, Isabel W C E Arends Latest development in the synthesis of ursodeoxycholic acid (UDCA): a critical review published pages: 470-483, ISSN: 1860-5397, DOI: 10.3762/bjoc.14.33 |
Beilstein Journal of Organic Chemistry 14 | 2020-02-20 |
| 2019 |
Victor R. L. J. Bloemendal, Daan Sondag, Hidde Elferink, Thomas J. Boltje, Jan. C. M. van Hest, Floris P. J. T. Rutjes A Revised Modular Approach to (-)- trans -Δ 8 -THC and Derivatives Through Late-Stage Suzuki-Miyaura Cross-Coupling Reactions published pages: 2289-2296, ISSN: 1434-193X, DOI: 10.1002/ejoc.201900059 |
European Journal of Organic Chemistry 2019/12 | 2020-02-20 |
| 2019 |
Xin Yang, Yaolei Wang, Ruixue Bai, Hulin Ma, Weihao Wang, Hejia Sun, Yuman Dong, Fengmei Qu, Qiming Tang, Ting Guo, Bernard P. Binks, Tao Meng Pickering emulsion-enhanced interfacial biocatalysis: tailored alginate microparticles act as particulate emulsifier and enzyme carrier published pages: 2229-2233, ISSN: 1463-9262, DOI: 10.1039/c8gc03573c |
Green Chemistry 21/9 | 2020-02-20 |
| 2019 |
Olivia Maria Morales-Gonzalez, Marc Escribà -Gelonch, Volker Hessel Life cycle assessment of vitamin D3 synthesis: from batch to photo-high p,T published pages: 2111-2127, ISSN: 0948-3349, DOI: 10.1007/s11367-019-01634-6 |
The International Journal of Life Cycle Assessment 24/12 | 2020-02-20 |
| 2020 |
Chenyue Zhang, Zhen Song, Can Jin, Job Nijhuis, Teng Zhou, Timothy Noël, Harald Gröger, Kai Sundmacher, Jan van Hest, Volker Hessel Screening of functional solvent system for automatic aldehyde and ketone separation in aldol reaction: A combined COSMO-RS and experimental approach published pages: 123399, ISSN: 1385-8947, DOI: 10.1016/j.cej.2019.123399 |
Chemical Engineering Journal 385 | 2020-02-20 |
| 2019 |
O.M. Morales-Gonzalez, C. Zhang, S. Li, V. Hessel Solvent impact assessment for the “One-Flow Functional Solvent Factory†published pages: 100024, ISSN: 2590-1400, DOI: 10.1016/j.cesx.2019.100024 |
Chemical Engineering Science: X 3 | 2020-02-20 |
| 2019 |
Katharina Hiebler, Sebastian Soritz, Kristian Gavric, Sam Birrer, Manuel C. Maier, Bianca Grabner, Heidrun Gruber-Woelfler Multistep synthesis of a valsartan precursor in continuous flow published pages: , ISSN: 2062-249X, DOI: 10.1007/s41981-019-00044-x |
Journal of Flow Chemistry | 2020-02-20 |
| 2019 |
Victor R. L. J. Bloemendal, Sam J. Moons, Jurriaan J. A. Heming, Mohamed Chayoua, Olaf Niesink, Jan C. M. van Hest, Thomas J. Boltje, Floris P. J. T. Rutjes Chemoenzymatic Synthesis of Sialic Acid Derivatives Using Immobilized N†Acetylneuraminate Lyase in a Continuous Flow Reactor published pages: , ISSN: 1615-4150, DOI: 10.1002/adsc.201900146 |
Advanced Synthesis & Catalysis | 2020-02-20 |
| 2019 |
Steven V. Ley, Yiding Chen, Daniel E. Fitzpatrick, Oliver May A New World for Chemical Synthesis? published pages: 792-802, ISSN: 0009-4293, DOI: 10.2533/chimia.2019.792 |
CHIMIA International Journal for Chemistry 73/10 | 2020-02-04 |
| 2020 |
Eiichi Watanabe, Yiding Chen, Oliver May, Steven V. Ley A Practical Method for Continuous Production of sp3â€Rich Compounds from (Hetero)Aryl Halides and Redoxâ€Active Esters published pages: 186-191, ISSN: 0947-6539, DOI: 10.1002/chem.201905048 |
Chemistry – A European Journal 26/1 | 2020-02-04 |
| 2020 |
Daniel E. Fitzpatrick, Matthew O\'Brien, Steven V. Ley A tutored discourse on microcontrollers, single board computers and their applications to monitor and control chemical reactions published pages: , ISSN: 2058-9883, DOI: 10.1039/c9re00407f |
Reaction Chemistry & Engineering | 2020-02-04 |
| 2019 |
Yiding Chen, Oliver May, David C. Blakemore, Steven V. Ley A Photoredox Coupling Reaction of Benzylboronic Esters and Carbonyl Compounds in Batch and Flow published pages: 6140-6144, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.9b02307 |
Organic Letters 21/15 | 2020-02-04 |
| 2017 |
Andreas Greb, Jian-Siang Poh, Stephanie Greed, Claudio Battilocchio, Patrick Pasau, David C. Blakemore, Steven V. Ley A Versatile Route to Unstable Diazo Compounds via Oxadiazolines and their Use in Aryl-Alkyl Cross-Coupling Reactions published pages: 16602-16605, ISSN: 1433-7851, DOI: 10.1002/anie.201710445 |
Angewandte Chemie International Edition 56/52 | 2020-01-20 |
| 2018 |
Dougal J. Ritson, Claudio Battilocchio, Steven V. Ley, John D. Sutherland Mimicking the surface and prebiotic chemistry of early Earth using flow chemistry published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-04147-2 |
Nature Communications 9/1 | 2020-01-20 |
| 2018 |
Katharina Hiebler, Georg J Lichtenegger, Manuel C Maier, Eun Sung Park, Renie Gonzales-Groom, Bernard P Binks, Heidrun Gruber-Woelfler Heterogeneous Pd catalysts as emulsifiers in Pickering emulsions for integrated multistep synthesis in flow chemistry published pages: 648-658, ISSN: 1860-5397, DOI: 10.3762/bjoc.14.52 |
Beilstein Journal of Organic Chemistry 14 | 2020-01-20 |
| 2018 |
M Teresa De Martino, Loai K E A Abdelmohsen, Floris P J T Rutjes, Jan C M van Hest Nanoreactors for green catalysis published pages: 716-733, ISSN: 1860-5397, DOI: 10.3762/bjoc.14.61 |
Beilstein Journal of Organic Chemistry 14 | 2020-01-20 |
| 2019 |
Lukas Schober, Shahilan Ratnam, Yasunobu Yamashita, Niklas Adebar, Matthias Pieper, Albrecht Berkessel, Volker Hessel, Harald Gröger An Asymmetric Organocatalytic Aldol Reaction of a Hydrophobic Aldehyde in Aqueous Medium Running in Flow Mode published pages: 1178-1184, ISSN: 0039-7881, DOI: 10.1055/s-0037-1610404 |
Synthesis 51/05 | 2020-01-20 |
| 2018 |
Yiding Chen, David C. Blakemore, Patrick Pasau, Steven V. Ley Three-Component Assembly of Multiply Substituted Homoallylic Alcohols and Amines Using a Flow Chemistry Photoreactor published pages: 6569-6572, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.8b02907 |
Organic Letters 20/20 | 2020-01-20 |
| 2018 |
Daniel E. Fitzpatrick, Robbie J. Mutton, Steven V. Ley In-line separation of multicomponent reaction mixtures using a new semi-continuous supercritical fluid chromatography system published pages: 799-806, ISSN: 2058-9883, DOI: 10.1039/c8re00107c |
Reaction Chemistry & Engineering 3/5 | 2020-01-20 |
| 2018 |
Yiding Chen, Marco Leonardi, Paul Dingwall, Ricardo Labes, Patrick Pasau, David C. Blakemore, Steven V. Ley Photochemical Homologation for the Preparation of Aliphatic Aldehydes in Flow published pages: 15558-15568, ISSN: 0022-3263, DOI: 10.1021/acs.joc.8b02721 |
The Journal of Organic Chemistry 83/24 | 2020-01-20 |
| 2018 |
Paul Dingwall, Andreas Greb, Lorène N. S. Crespin, Ricardo Labes, Biagia Musio, Jian-Siang Poh, Patrick Pasau, David C. Blakemore, Steven V. Ley C–H functionalisation of aldehydes using light generated, non-stabilised diazo compounds in flow published pages: 11685-11688, ISSN: 1359-7345, DOI: 10.1039/c8cc06202a |
Chemical Communications 54/83 | 2020-01-20 |
| 2018 |
Daniel E. Fitzpatrick, Timothé Maujean, Amanda C. Evans, Steven V. Ley Across-the-World Automated Optimization and Continuous-Flow Synthesis of Pharmaceutical Agents Operating Through a Cloud-Based Server published pages: 15128-15132, ISSN: 1433-7851, DOI: 10.1002/anie.201809080 |
Angewandte Chemie International Edition 57/46 | 2020-01-20 |
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ONE-FLOW" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "ONE-FLOW" are provided by the European Opendata Portal: CORDIS opendata.