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TEN-COMPLEX TERMINATED
Teneurin interactions in the neuronal synapse
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0TEN-COMPLEX project word cloud
Explore the words cloud of the TEN-COMPLEX project. It provides you a very rough idea of what is the project "TEN-COMPLEX" about.
neurons
primary
skill
synapse
neurobiology
developmental
complements
unclear
enabled
scientist
me
latrophilin
diseases
learning
critical
understand
complexes
structural
teneurin1
whereas
background
ultimately
disorders
electron
molecule
adhesion
dimerization
structure
cryo
microscopy
function
hippocampal
independent
synaptic
parallel
autism
interact
intricate
team
off
family
neural
synapses
molecular
single
cell
individual
memory
draws
macro
dissecting
functional
teneurin
circuits
functions
therapeutics
teneurins
mechanisms
protein
biology
proteins
small
treat
containing
underlie
teneurin2
binding
line
molecules
conducting
particle
circuitry
connections
Project "TEN-COMPLEX" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITEIT UTRECHT
Organization address contact info |
| Coordinator Country | Netherlands [NL] |
| Total cost | 165˙598 € |
| EC max contribution | 165˙598 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2015 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-01-01 to 2018-12-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITEIT UTRECHT | NL (UTRECHT) | coordinator | 165˙598.00 |
Map
Project objective
Synapses, connections between neurons, are critical to the formation of neural circuits. Functional neural circuits control intricate processes such as learning and memory, whereas failure in neural circuitry formation can lead to developmental disorders including autism.
At the molecular level, synapse formation is enabled by cell-adhesion molecules that interact across the synapse. At present, many individual proteins have been identified that contribute to synaptic cell adhesion, but it is unclear how these individual proteins team up in macro-molecular complexes. I will focus on synaptic cell-adhesion complexes containing Teneurins, a protein family whose essential role in synapse formation has only recently been characterized.
To understand how Teneurin complexes promote synapse formation, I aim to determine the molecular mechanisms that underlie Teneurin1 and Teneurin2 dimerization, including complex formation with their recently identified binding partner Latrophilin. To achieve this goal, I will determine the structure of Teneurin protein complexes using single particle electron cryo-microscopy. In parallel, I will study the function of Teneurin complexes in synapse formation using primary hippocampal neurons. Dissecting the molecular mechanisms that underlie Teneurin functions might ultimately advance small molecule therapeutics to treat developmental diseases, including autism.
The work I propose here, draws upon my background in the field of developmental neurobiology, but complements that background with new knowledge and skill sets in structural biology to set me off conducting my own line of research as an independent scientist.
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The information about "TEN-COMPLEX" are provided by the European Opendata Portal: CORDIS opendata.
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