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BINAMA TERMINATED

Biomimicking nanostructured materials via intra(inter)molecular folding of sequence-controlled polymers

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

BINAMA project word cloud

Explore the words cloud of the BINAMA project. It provides you a very rough idea of what is the project "BINAMA" about.

living environment nature intramolecular radical binama transcription pave chains monomers functions mimic charge replication interactions polymer complicated sequences incorporation hydrogen sequence polymers fold proteins precise functional intermolecular folding nanostructure considerable polymerization translation remarkable motifs structures pi dna employed catalyst chemistry attracted bioanalogues synthetic biopolymers nanostructures adopting intracellular utilizing synthesize chaperone induce disulphide bonding natural patterns biomimicking subsequently materials hydrophobic first domains replicating perfectly employs configurations mimicking

Project "BINAMA" data sheet

The following table provides information about the project.

Coordinator	THE UNIVERSITY OF WARWICK Organization address address: Kirby Corner Road - University House city: COVENTRY postcode: CV4 8UW website: www.warwick.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	https://warwick.ac.uk/fac/sci/chemistry/research/haddleton/haddletongroup
Total cost	211˙825 €
EC max contribution	211˙825 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-GF
Starting year	2017
Duration (year-month-day)	from 2017-01-20 to 2019-07-19

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE UNIVERSITY OF WARWICK THE UNIVERSITY OF WARWICK Organization address address: Kirby Corner Road - University House city: COVENTRY postcode: CV4 8UW website: www.warwick.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (COVENTRY)	coordinator	211˙825.00
2	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Organization address address: FRANKLIN STREET 1111, 12 FLOOR city: OAKLAND CA postcode: 94607 website: http://www.universityofcalifornia.edu/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (OAKLAND CA)	partner	0.00

Map

Project objective

Nature employs various polymerization processes (e.g. DNA replication, transcription and translation of proteins) in order to synthesize biopolymers such as DNA and proteins with controlled sequences and configurations. Such remarkable and complicated structures can fold into precise nanostructures via intramolecular and intermolecular interactions and thus replicating these domains via synthetic polymers has recently attracted considerable interest. The goal of BINAMA is to synthesize biomimicking nanostructure materials via intramolecular folding of sequence-controlled polymers in the presence of a “real” catalyst/chaperone, thus mimicking the intracellular environment. For the first part of the project, the sequence of functional monomers will be controlled utilizing controlled living radical polymerization methods. Subsequently, the incorporation of these monomers will induce hydrogen bonding, hydrophobic/hydrophobic, pi-pi, charge and disulphide interactions typically employed by proteins in order to facilitate the controlled folding of the polymer chains, adopting natural motifs and patterns. The ability to mimic these perfectly defined sequence-controlled polymers (e.g. DNA and proteins) via synthetic polymer chemistry will pave the way for synthetic bioanalogues and could also enhance their functions and properties.

Publications

List of publications.
year	authors and title	journal	last update
2019	Arkadios Marathianos, Evelina Liarou, Athina Anastasaki, Richard Whitfield, Matthew Laurel, Alan M. Wemyss, David M. Haddleton Photo-induced copper-RDRP in continuous flow without external deoxygenation published pages: 4402-4406, ISSN: 1759-9954, DOI: 10.1039/c9py00945k	Polymer Chemistry 10/32	2019-10-28
2018	Richard Whitfield, Athina Anastasaki, Glen R. Jones, David M. Haddleton Cu(0)-RDRP of styrene: balancing initiator efficiency and dispersity published pages: 4395-4403, ISSN: 1759-9954, DOI: 10.1039/c8py00814k	Polymer Chemistry 9/34	2019-06-06
2018	Evelina Liarou, Richard Whitfield, Athina Anastasaki, Nikolaos G. Engelis, Glen R. Jones, Kelly Velonia, David M. Haddleton Copper-Mediated Polymerization without External Deoxygenation or Oxygen Scavengers published pages: 8998-9002, ISSN: 1433-7851, DOI: 10.1002/anie.201804205	Angewandte Chemie International Edition 57/29	2019-06-06
2018	Glen R. Jones, Athina Anastasaki, Richard Whitfield, Nikolaos Engelis, Evelina Liarou, David M. Haddleton Copper-Mediated Reversible Deactivation Radical Polymerization in Aqueous Media published pages: 10468-10482, ISSN: 1433-7851, DOI: 10.1002/anie.201802091	Angewandte Chemie International Edition 57/33	2019-06-06
2018	Richard Whitfield, Athina Anastasaki, Nghia P. Truong, Alexander B. Cook, Marta Omedes-Pujol, Vanessa Loczenski Rose, Tuan A. H. Nguyen, James A. Burns, SÃ©bastien Perrier, Thomas P. Davis, David M. Haddleton Efficient Binding, Protection, and Self-Release of dsRNA in Soil by Linear and Star Cationic Polymers published pages: 909-915, ISSN: 2161-1653, DOI: 10.1021/acsmacrolett.8b00420	ACS Macro Letters 7/8	2019-06-06
2018	Nikolaos G. Engelis, Athina Anastasaki, Richard Whitfield, Glen R. Jones, Evelina Liarou, Vasiliki Nikolaou, Gabit Nurumbetov, David M. Haddleton Sequence-Controlled Methacrylic Multiblock Copolymers: Expanding the Scope of Sulfur-Free RAFT published pages: 336-342, ISSN: 0024-9297, DOI: 10.1021/acs.macromol.7b01987	Macromolecules 51/2	2019-06-06
2017	Athina Anastasaki, Bernd Oschmann, Johannes Willenbacher, Anna Melker, Martin H. C. Vanâ€…Son, Nghia P. Truong, Morgan W. Schulze, Emre H. Discekici, Alaina J. McGrath, Thomas P. Davis, Christopher M. Bates, Craig J. Hawker One-Pot Synthesis of ABCDE Multiblock Copolymers with Hydrophobic, Hydrophilic, and Semi-Fluorinated Segments published pages: 14483-14487, ISSN: 1433-7851, DOI: 10.1002/anie.201707646	Angewandte Chemie International Edition 56/46	2019-02-28

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