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GSTHgNDD SIGNED

Role of GST gene variation in susceptibility to mercury (Hg)-induced neurodevelopmental disorders (NDD) in zebrafish

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 GSTHgNDD project word cloud

Explore the words cloud of the GSTHgNDD project. It provides you a very rough idea of what is the project "GSTHgNDD" about.

conduct    serve    predisposition    wellbeing    skills    dominant    interactions    adverse    interdisciplinary    exposure    integrating    zebrafish    career    metal    glutathione    collaborations    outcomes    crispr    population    disease    mental    original    demographic    quality    ec    professional    genetic    dr    alleviation    risk    individual    environmental    training    childhood    transcriptomic    brennan    position    developmental    influence    toxicology    behavioural    assessing    generate    leads    medicine    mercury    predictive    transferase    biochemical    toxicity    health    aetiology    genetics    phenotypes    integrate    embryos    insult    model    maturity    relate    older    gene    later    personalized    diseases    relationship    detection    researcher    background    respect    heavy    toxin    mutant    environment    modifications    gst    group    markers    disorders    communicable    wild    spectrum    presented    neurodevelopmental    prevalence    altered    uses    epigenomic    ages   

Project "GSTHgNDD" data sheet

The following table provides information about the project.

Coordinator
QUEEN MARY UNIVERSITY OF LONDON 

Organization address
address: 327 MILE END ROAD
city: LONDON
postcode: E1 4NS
website: http://www.qmul.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-06-20   to  2020-06-04

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    QUEEN MARY UNIVERSITY OF LONDON UK (LONDON) coordinator 183˙454.00

Map

 Project objective

Environmental factors, including the heavy metal mercury, are recognized as having a dominant influence on the aetiology and prevalence of neurodevelopmental behavioural disorders. This proposal will develop a new model for assessing the role of gene:environment interactions, specifically genetic predisposition for toxicity, in risk for disease, and identify early markers predictive of toxicity and later phenotypes. This will directly relate to the EC work program for Health, demographic change and wellbeing, with respect to both 'Personalized medicine' for non-communicable diseases and 'Early development' addressing mental health from childhood to older ages. The project uses the zebrafish model to investigate the relationship between glutathione-S-transferase (GST)-related genetic background, developmental exposure to mercury, and risk for neurodevelopmental disorders. This will be achieved by exposure of wild-type and CRISPR-generated Gst mutant embryos to mercury, and testing whether genetic predisposition leads to increased risk for toxin-induced behavioural phenotypes. We will test for altered biochemical, transcriptomic and epigenomic modifications that may serve as potential early markers for insult. The results obtained in this proposal will have significant impact on the ability to conduct individual and population specific toxicity risk assessment, and may lead to novel measures for early detection of increased risk and alleviation of potential adverse outcomes. The high-quality original research presented in the proposal will not only enable the Experienced Researcher to reach a position of professional maturity in her career, but will also allow her to develop a spectrum of new and interdisciplinary skills, integrating her previous training and knowledge into the behavioural genetics skills set. This project will also allow Dr. Brennan's group to integrate developmental toxicology into existing behavioural research, and will generate new collaborations.

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The information about "GSTHGNDD" are provided by the European Opendata Portal: CORDIS opendata.

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