Opendata, web and dolomites

SymMech

Unravelling the mechanisms behind bacterial symbiosis in insects

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 SymMech project word cloud

Explore the words cloud of the SymMech project. It provides you a very rough idea of what is the project "SymMech" about.

lethality    mediated    mechanisms    symbiont    raised    biology    solid    competing    microorganisms    symbiotic    enormous    additionally    offspring    time    specialised    wasp    invertebrates    transmission    modify    impeding    tools    diminish    inducing    classic    pests    culturable    function    strains    utilize    little    microbiological    borne    screens    infects    independent    grown    knockout    gene    dependent    engineer    phenotype    genes    insect    symbionts    tradis    son    possibility    protection    hypothesis    vector    manipulation    thriving    nasonia    parasitoid    pathogen    strategies    symbioisis    arsenophonus    sk    amongst    outside    bacterial    eliminate    alteration    nasoniae    vitripennis    combined    elucidation    permit    acquisition    killing    responsible    humans    chemical    bacterium    biological    lifestyle    identification    host    reduce    male    life    arthropods    performing    endosymbionts    molecular    elucidate    plants    hosts    niches    strategy    predator    ground    reproductive    competence    first    symbiosis    diseases    distributed    nutrient    interference    desired    few   

Project "SymMech" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF LIVERPOOL 

Organization address
address: BROWNLOW HILL 765 FOUNDATION BUILDING
city: LIVERPOOL
postcode: L69 7ZX
website: www.liverpool.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://sites.google.com/site/hurstlab/home/greg
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2018-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF LIVERPOOL UK (LIVERPOOL) coordinator 183˙454.00

Map

 Project objective

Bacterial endosymbionts are widely distributed amongst invertebrates and have an enormous impact upon the biology of their hosts, being responsible for nutrient acquisition, predator protection and interference with the host reproductive strategies. Their ability to reduce vector competence has raised the possibility of using endosymbionts as a strategy to eliminate or diminish vector-borne pathogen transmission to humans and plants. A crucial step in manipulation of symbionts is the elucidation of the genes involved in symbiosis. Symbionts are highly adapted to hosts, thriving in highly specialised niches with little interference from competing microorganisms. The genes that permit this lifestyle are not known in any case, because most symbionts cannot be grown outside their host, thus impeding classic microbiological loss of function screens to elucidate the molecular mechanisms responsible for symbioisis. In this project, I will utilize Arsenophonus nasoniae, one of the few culturable symbionts, to establish for the first time the genes and systems required for symbiotic life. This bacterium infects the parasitoid wasp Nasonia vitripennis inducing lethality in the male offspring (son-killing = sk). The major objective of this project is to elucidate by the first time genes that are essential for the symbiosis between a bacterium and an insect using hypothesis-independent TraDis approach combined with hypothesis-dependent gene knockout approaches. Identification of the genes involved in symbiosis may allow us to modify the host range of symbionts or engineer strains that produce the desired phenotype. Additionally, this project will provide solid ground for the identification of genes involved in reproductive manipulation of arthropods allowing performing symbiont-mediated alteration of host biology. Both objectives are crucial for the development of novel biological and chemical tools against major vector-borne diseases and pests.

 Publications

year authors and title journal last update
List of publications.
2019 Pol Nadal‐Jimenez, Joanne S. Griffin, Lianne Davies, Crystal L. Frost, Marco Marcello, Gregory D. D. Hurst
Genetic manipulation allows in vivo tracking of the life cycle of the son‐killer symbiont, Arsenophonus nasoniae , and reveals patterns of host invasion, tropism and pathology
published pages: , ISSN: 1462-2912, DOI: 10.1111/1462-2920.14724
Environmental Microbiology 2019-09-02

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SYMMECH" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SYMMECH" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

TheaTheor (2018)

Theorizing the Production of 'Comedia Nueva': The Process of Play Configuration in Spanish Golden Age Theater

Read More  

DNANanoProbes (2019)

Design of light-harvesting DNA-nanoprobes with ratiometric signal amplification for fluorescence imaging of live cells.

Read More  

PmNC (2019)

Policy-making of early nature conservation. The Netherlands and the United Kingdom compared, 1930-1960

Read More