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STIMUNITY SIGNED

Preclinical validation of a novel immunogenic composition to stimulate innate immunity

Total Cost €

EC-Contrib. €

Partnership

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STIMUNITY project word cloud

Explore the words cloud of the STIMUNITY project. It provides you a very rough idea of what is the project "STIMUNITY" about.

proof translational clinical diseases particles containing cancer models immune packaged innovative induce plan messenger activators discovered cgamp infectious immunotherapy virus vlps treat implicated sting mouse viruses viral stimulate immunity cells small idea tumoral cgas anti antitumoral potent

Project "STIMUNITY" data sheet

The following table provides information about the project.

Coordinator	INSTITUT CURIE Organization address address: rue d'Ulm 26 city: PARIS postcode: 75231 website: www.curie.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Total cost	150˙000 €
EC max contribution	150˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2016-PoC
Funding Scheme	ERC-POC
Starting year	2017
Duration (year-month-day)	from 2017-02-01 to 2018-07-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUT CURIE INSTITUT CURIE Organization address address: rue d'Ulm 26 city: PARIS postcode: 75231 website: www.curie.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	coordinator	150˙000.00

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Project objective

Immunotherapy is a promising approach to treat cancer and infectious diseases, but innovative approaches are required. The cGAS-cGAMP-STING pathway can induce a potent immune response against viruses. It is also implicated in antitumoral immune responses that are effective. We have recently discovered that the small second messenger cGAMP can be packaged by viruses to stimulate immunity in target cells. We have developed methods to produce non-infectious virus-like particles containing cGAMP (cGAMP-VLPs) that strongly stimulate this innovative immune pathway. We will test the idea that cGAMP-VLPs are potent activators of anti-tumoral and anti-viral immunity. To reach this proof-of-concept, we propose pre-clinical development plan in translational mouse models.

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The information about "STIMUNITY" are provided by the European Opendata Portal: CORDIS opendata.