Explore the words cloud of the LamelliActin project. It provides you a very rough idea of what is the project "LamelliActin" about.
The following table provides information about the project.
Coordinator |
INSTITUTE OF SCIENCE AND TECHNOLOGYAUSTRIA
Organization address contact info |
Coordinator Country | Austria [AT] |
Project website | https://ist.ac.at/research/research-groups/sixt-group/lamelliactin/ |
Total cost | 178˙156 € |
EC max contribution | 178˙156 € (100%) |
Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
Code Call | H2020-MSCA-IF-2016 |
Funding Scheme | MSCA-IF-EF-ST |
Starting year | 2017 |
Duration (year-month-day) | from 2017-03-01 to 2019-02-28 |
Take a look of project's partnership.
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1 | INSTITUTE OF SCIENCE AND TECHNOLOGYAUSTRIA | AT (KLOSTERNEUBURG) | coordinator | 178˙156.00 |
Cell migration is centrally involved in embryonic development, regeneration and immune surveillance. However, when misguided it also contributes to the pathogenesis of Europe’s socioeconomic most relevant diseases including cancer, cardiovascular diseases and chronic inflammation. Accordingly, better understanding the fundamental mechanisms of cell migration is of direct clinical relevance. In order to migrate within a multicellular context, cells have to negotiate physical constraints, such as other cells and the extracellular matrix and effectively integrate mechanical challenges into directional decision-making. This proposal suggests a combined cell biological and biophysical approach to provide a quantitative understanding of the underlying molecular and mechanical principles. We will focus on the prototypic force-generating structure of migrating cells the lamellipodium - a flat sheet-like protrusion of dendritic actin networks at the leading front of migrating cells. We will decipher the ultrastructural adaptations of lamellipodial actin networks with single filament resolution and characterize how nucleation, elongation, depolymerization and crosslinking of actin filaments coordinate circumnavigation of mechanical obstacles. Technically, these questions will be addressed in a multidisciplinary approach by employing correlative fluorescence and electron tomography in combination with artificial environments engineered using microfluidics and substrate micropatterning, as well as genetic approaches and biological modelling. Importantly, findings will ultimately be challenged in living tissues. The expected results will generate an integrated view of force-adaptations of actin networks in living cells and will not only impact the fields of cell biology and biophysics but also cancer biology, immunology and developmental biology.
year | authors and title | journal | last update |
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2018 |
Miroslav Hons, Aglaja Kopf, Robert Hauschild, Alexander Leithner, Florian Gaertner, Jun Abe, Jörg Renkawitz, Jens V. Stein, Michael Sixt Chemokines and integrins independently tune actin flow and substrate friction during intranodal migration of T cells published pages: 606-616, ISSN: 1529-2908, DOI: 10.1038/s41590-018-0109-z |
Nature Immunology 19/6 | 2019-09-02 |
2017 |
Florian Gaertner, Zerkah Ahmad, Gerhild Rosenberger, Shuxia Fan, Leo Nicolai, Benjamin Busch, Gökce Yavuz, Manja Luckner, Hellen Ishikawa-Ankerhold, Roman Hennel, Alexandre Benechet, Michael Lorenz, Sue Chandraratne, Irene Schubert, Sebastian Helmer, Bianca Striednig, Konstantin Stark, Marek Janko, Ralph T. Böttcher, Admar Verschoor, Catherine Leon, Christian Gachet, Thomas Gudermann, Michael Mederos y Schnitzler, Zachary Pincus, Matteo Iannacone, Rainer Haas, Gerhard Wanner, Kirsten Lauber, Michael Sixt, Steffen Massberg Migrating Platelets Are Mechano-scavengers that Collect and Bundle Bacteria published pages: 1368-1382.e23, ISSN: 0092-8674, DOI: 10.1016/j.cell.2017.11.001 |
Cell 171/6 | 2019-09-02 |
2018 |
Shuxia Fan, Michael Lorenz, Steffen Massberg, Florian Gaertner Platelet Migration and Bacterial Trapping Assay under Flow published pages: , ISSN: 2331-8325, DOI: 10.21769/bioprotoc.3018 |
BIO-PROTOCOL 8/18 | 2019-09-02 |
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The information about "LAMELLIACTIN" are provided by the European Opendata Portal: CORDIS opendata.