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ExoSensor

A Nano-photoelectric Exosome Biosensor for Point-of-care Diagnosis of Early-stage Cancer

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 ExoSensor project word cloud

Explore the words cloud of the ExoSensor project. It provides you a very rough idea of what is the project "ExoSensor" about.

molecular    biology    appealing    ideal    protein    3d    negative    mentoring    printing    imaging    exosome    collaborators    chemistry    animal    college    guy    resides    portable    techniques    kings    dual    london    microscopy    cell    detection    thomas    ltd    rapid    prototype    false    platform    novelty    cooperation    industrial    universal    avoiding    health    engineering    pinpointing    synergetic    feasibility    exosensor    cardiff    markers    tests    toxicology    disease    handling    academic    fellowship    final    easily    round    nanosensing    pancreatic    creatively    optical    sensitive    hospital    printed    therapeutics    stage    valuable    reservoir    secondment    accurate    biomarkers    advise    utmost    st    analytical    king    researcher    confirm    interdisplinary    diagnostics    training    fabricate    biomarker    diagnosis    biosensor    electrochemical    signalling    quantitatively    circulating    samples    simultaneous    seek    poct    nanotechnology    astrazeneca    marker    positive    contributions    single    gpc1    monitoring    exosomes    clinical    university    transfer    validation    quality    unmet    accessible    integrating    cancer    tumour    reliability    commercial   

Project "ExoSensor" data sheet

The following table provides information about the project.

Coordinator		 KING'S COLLEGE LONDON 

Organization address
address: STRAND
city: LONDON
postcode: WC2R 2LS
website: www.kcl.ac.uk

contact info
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name: n.a.
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function: n.a.
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 Coordinator Country United Kingdom [UK]
 Project website https://kclpure.kcl.ac.uk/portal/en/projects/exosensor--a-nanophotoelectric-exosome-biosensor-for-pointofcare-diagnosis-of-earlystage-cancer
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-10-11   to  2019-10-10

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KING'S COLLEGE LONDON UK (LONDON) coordinator 183˙454.00

Map

 Project objective

Tumour-derived circulating exosomes are an ideal, easily accessible reservoir of cancer biomarkers to assess disease processes. Quantitatively pinpointing exosome tumour markers, a clinical field of an unmet need is appealing, yet challenging. The main objectives of the proposal are to develop an integrated dual-signalling exosome biosensor (ExoSensor) for rapid and specific detection of GPC1 exosomes and fabricate a 3D-printed portable prototype for POCT diagnosis of pancreatic cancer, offering an universal technology for clinical cancer diagnosis through quantitatively monitoring the protein marker of cancer-derived exosomes, in a simple way. The novelty resides in creatively achieving accurate, sensitive, and simultaneous detection of exosomes by integrating two synergetic methods (optical and electrochemical) on one single nanosensing platform, avoiding false positive/negative results to the utmost and ensuring the reliability of tests. This European Fellowship at Kings College London will provide the researcher with advanced technical training in molecular biology, exosome, cancer cell and animal handling, analytical chemistry and microscopy and imaging techniques, as well as academic mentoring in research management. A secondment to Cardiff University will seek and confirm the best possible biomarker(s). Another secondment to the industrial partner AstraZeneca Ltd will offer access to various exosomes research (diagnostics, toxicology and therapeutics) and evaluate the feasibility of commercial transfer if possible. Guy’s, St Thomas, and King’s College Hospital (part of King’s Health Partners) will provide valuable clinical samples for final validation stage. Other collaborators will advise on 3D-printing, pancreatic cancer and biomarkers. These interdisplinary contributions are essential and well-related to the proposal research, fostering high-quality cooperation from biology, chemistry, engineering, nanotechnology and clinical areas the other way round.

 Publications

year authors and title journal last update
List of publications.
2019 Farid N. Faruqu, Julie Tzu-Wen Wang, Lizhou Xu, Luke McNickle, Eden Ming-Yiu Chong, Adam Walters, Mark Gurney, Aled Clayton, Lesley A. Smyth, Robert Hider, Jane Sosabowski, Khuloud T. Al-Jamal
Membrane Radiolabelling of Exosomes for Comparative Biodistribution Analysis in Immunocompetent and Immunodeficient Mice - A Novel and Universal Approach
published pages: 1666-1682, ISSN: 1838-7640, DOI: 10.7150/thno.27891 		Theranostics 9/6 2020-02-27
2018 Farid N. Faruqu, Lizhou Xu, Khuloud T. Al-Jamal
Preparation of Exosomes for siRNA Delivery to Cancer Cells
published pages: , ISSN: 1940-087X, DOI: 10.3791/58814 		Journal of Visualized Experiments 142 2020-02-27

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The information about "EXOSENSOR" are provided by the European Opendata Portal: CORDIS opendata.

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