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ExoSensor

A Nano-photoelectric Exosome Biosensor for Point-of-care Diagnosis of Early-stage Cancer

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 ExoSensor project word cloud

Explore the words cloud of the ExoSensor project. It provides you a very rough idea of what is the project "ExoSensor" about.

biosensor    reservoir    final    resides    nanosensing    cancer    accessible    utmost    college    university    health    diagnostics    universal    molecular    imaging    detection    easily    guy    nanotechnology    marker    circulating    exosensor    exosomes    protein    negative    false    monitoring    samples    industrial    st    printing    simultaneous    clinical    printed    accurate    collaborators    biomarker    animal    diagnosis    3d    signalling    transfer    secondment    portable    unmet    markers    avoiding    hospital    fabricate    rapid    round    techniques    novelty    toxicology    stage    training    kings    valuable    tumour    engineering    dual    exosome    interdisplinary    cooperation    king    creatively    electrochemical    confirm    positive    academic    researcher    biology    optical    integrating    microscopy    prototype    quantitatively    ideal    london    contributions    analytical    validation    seek    commercial    cardiff    pancreatic    chemistry    handling    tests    synergetic    thomas    astrazeneca    single    poct    mentoring    quality    sensitive    therapeutics    gpc1    pinpointing    advise    fellowship    ltd    cell    reliability    disease    biomarkers    platform    feasibility    appealing   

Project "ExoSensor" data sheet

The following table provides information about the project.

Coordinator		 KING'S COLLEGE LONDON 

Organization address
address: STRAND
city: LONDON
postcode: WC2R 2LS
website: www.kcl.ac.uk

contact info
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 Coordinator Country United Kingdom [UK]
 Project website https://kclpure.kcl.ac.uk/portal/en/projects/exosensor--a-nanophotoelectric-exosome-biosensor-for-pointofcare-diagnosis-of-earlystage-cancer
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-10-11   to  2019-10-10

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KING'S COLLEGE LONDON UK (LONDON) coordinator 183˙454.00

Map

 Project objective

Tumour-derived circulating exosomes are an ideal, easily accessible reservoir of cancer biomarkers to assess disease processes. Quantitatively pinpointing exosome tumour markers, a clinical field of an unmet need is appealing, yet challenging. The main objectives of the proposal are to develop an integrated dual-signalling exosome biosensor (ExoSensor) for rapid and specific detection of GPC1 exosomes and fabricate a 3D-printed portable prototype for POCT diagnosis of pancreatic cancer, offering an universal technology for clinical cancer diagnosis through quantitatively monitoring the protein marker of cancer-derived exosomes, in a simple way. The novelty resides in creatively achieving accurate, sensitive, and simultaneous detection of exosomes by integrating two synergetic methods (optical and electrochemical) on one single nanosensing platform, avoiding false positive/negative results to the utmost and ensuring the reliability of tests. This European Fellowship at Kings College London will provide the researcher with advanced technical training in molecular biology, exosome, cancer cell and animal handling, analytical chemistry and microscopy and imaging techniques, as well as academic mentoring in research management. A secondment to Cardiff University will seek and confirm the best possible biomarker(s). Another secondment to the industrial partner AstraZeneca Ltd will offer access to various exosomes research (diagnostics, toxicology and therapeutics) and evaluate the feasibility of commercial transfer if possible. Guy’s, St Thomas, and King’s College Hospital (part of King’s Health Partners) will provide valuable clinical samples for final validation stage. Other collaborators will advise on 3D-printing, pancreatic cancer and biomarkers. These interdisplinary contributions are essential and well-related to the proposal research, fostering high-quality cooperation from biology, chemistry, engineering, nanotechnology and clinical areas the other way round.

 Publications

year authors and title journal last update
List of publications.
2019 Farid N. Faruqu, Julie Tzu-Wen Wang, Lizhou Xu, Luke McNickle, Eden Ming-Yiu Chong, Adam Walters, Mark Gurney, Aled Clayton, Lesley A. Smyth, Robert Hider, Jane Sosabowski, Khuloud T. Al-Jamal
Membrane Radiolabelling of Exosomes for Comparative Biodistribution Analysis in Immunocompetent and Immunodeficient Mice - A Novel and Universal Approach
published pages: 1666-1682, ISSN: 1838-7640, DOI: 10.7150/thno.27891 		Theranostics 9/6 2020-02-27
2018 Farid N. Faruqu, Lizhou Xu, Khuloud T. Al-Jamal
Preparation of Exosomes for siRNA Delivery to Cancer Cells
published pages: , ISSN: 1940-087X, DOI: 10.3791/58814 		Journal of Visualized Experiments 142 2020-02-27

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The information about "EXOSENSOR" are provided by the European Opendata Portal: CORDIS opendata.

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