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GlycoNanoPep

Glyco and Nano Peptide Conjugates for Selective Cell Penetration

Total Cost €

EC-Contrib. €

Partnership

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GlycoNanoPep project word cloud

Explore the words cloud of the GlycoNanoPep project. It provides you a very rough idea of what is the project "GlycoNanoPep" about.

right carbohydrate peptides receptors generation discoveries combine probes cytotoxic biology cells hybrids glycochemistry molecular penetrating fundamental action dynamic responsive transporters cell limitation cargo interactions hold selective crispr peptide stimuli moment expertise linkers release stands trigger background cargos transport assist imaging glycopeptides bonds incorporate nanoparticles guest conjugated critical internalized supramolecular consist strategy expand therapeutic technologies host glycoconjugated group synthetic agents escape efficient membrane nucleotides vehicles biophysics multifunctional biocompatible techniques health endosomal proteins

Project "GlycoNanoPep" data sheet

The following table provides information about the project.

Coordinator	UNIVERSIDAD DE SANTIAGO DE COMPOSTELA Organization address address: COLEXIO DE SAN XEROME PRAZA DO OBRADOIRO S/N city: SANTIAGO DE COMPOSTELA postcode: 15782 website: http://www.usc.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	158˙121 €
EC max contribution	158˙121 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-04-01 to 2019-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSIDAD DE SANTIAGO DE COMPOSTELA UNIVERSIDAD DE SANTIAGO DE COMPOSTELA Organization address address: COLEXIO DE SAN XEROME PRAZA DO OBRADOIRO S/N city: SANTIAGO DE COMPOSTELA postcode: 15782 website: http://www.usc.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (SANTIAGO DE COMPOSTELA)	coordinator	158˙121.00

Map

Project objective

The next generation therapeutic agents such as proteins, nucleotides, cytotoxic agents and molecular probes hold promising properties to solve many crucial health issues. However, efficient and selective transport of this therapeutic cargos and imaging probes into the right cells at the right moment stands as a fundamental limitation of these new technologies.

In this action we will develop a new generation of highly efficient, selective and biocompatible supramolecular vehicles for specific cell delivery. This strategy will consist in the implementation of dynamic bonds as linkers for glycoconjugated cell penetrating peptides. These peptide hybrids will be recognized very specifically carbohydrate receptors and internalized. These stimuli responsive dynamic bonds will assist in critical steps of the delivery process such as the cargo release and endosomal escape.

We will expand this strategy to incorporate glycopeptides conjugated into multifunctional nanoparticles through host-guest interactions. We will implement state of the art synthetic, biophysics and cell biology techniques to identify new supramolecular selective membrane transporters.

This action will combine the glycochemistry background of the applicant with the expertise in membrane transport of the host group. The potential discoveries will trigger new opportunities in the delivery of the next-generation probes and proteins (i.e. CRISPR).

Publications

List of publications.
year	authors and title	journal	last update
2018	Alejandro MÃ©ndez-Ardoy, Juan R. Granja, Javier Montenegro pH-Triggered self-assembly and hydrogelation of cyclic peptide nanotubes confined in water micro-droplets published pages: 391-396, ISSN: 2055-6756, DOI: 10.1039/c8nh00009c	Nanoscale Horizons 3/4	2020-01-23
2018	Alejandro MÃ©ndezâ€Ardoy, Irene LostalÃ©â€Seijo, Javier Montenegro Where in the Cell Is our Cargo? Methods Currently Used To Study Intracellular Cytosolic Localisation published pages: 488-498, ISSN: 1439-4227, DOI: 10.1002/cbic.201800390	ChemBioChem 20/4	2020-01-23

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The information about "GLYCONANOPEP" are provided by the European Opendata Portal: CORDIS opendata.