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GOLDENSENS

Intrinsically chiral gold nanoclusters as enantiodiscriminating sensors for methamphetamines.

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

GOLDENSENS project word cloud

Explore the words cloud of the GOLDENSENS project. It provides you a very rough idea of what is the project "GOLDENSENS" about.

enantioselective training methamphetamines goldensens spectroscopy preparation enantiomeric materials clarify protecting sensors infrared achiral themselves whereas nmr combined nanoclusters intrinsically surface enantiodiscrimination theoretical biological chirality functional psychotropic start chiral nanoscale drug refine competences investigation separation academic diffuse bear cluster nasal ultimately quantify nanotechnology sr transfer mechanism ligands frontier decongestant thiols acquiring au38 gold conferring enantiomer enantiodiscriminating prepared modulation class independent medicine techniques soft chemical researcher optical configuration chiroptical career calculations absolute clusters 24 first scientific environment skills interactions asymmetric groups

Project "GOLDENSENS" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITE DE GENEVE Organization address address: RUE DU GENERAL DUFOUR 24 city: GENEVE postcode: 1211 website: www.unige.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Switzerland [CH]
Project website	http://www.unige.ch/sciences/chifi/Buergi/start.html
Total cost	175˙419 €
EC max contribution	175˙419 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-07-01 to 2019-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITE DE GENEVE UNIVERSITE DE GENEVE Organization address address: RUE DU GENERAL DUFOUR 24 city: GENEVE postcode: 1211 website: www.unige.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (GENEVE)	coordinator	175˙419.00

Map

Project objective

'The GOLDENSENS project aims at creating a new class of enantiodiscriminating sensors for methamphetamines based on intrinsically chiral Au38(SR)24 nanoclusters. These materials have unique optical properties which make them capable of conferring chirality to thiols protecting their surface, even when ligands themselves are achiral. The result of this chirality transfer is the formation of an asymmetric environment on the cluster surface which will be used for the enantiodiscrimination of D- and L-methamphetamines which can have distinct biological effects (The D-enantiomer is diffuse as psychotropic drug, whereas the L-enantiomer have been applied in medicine as in nasal decongestant). The first objective of GOLDENSENS will be the preparation of functional Au38 clusters. The protecting thiols of these novel clusters will bear specific chemical groups able to increase the enantioselective interactions with methamphetamines. The second objective will be the investigation of chiral properties of these gold nanoclusters by a combined chiroptical techniques and theoretical calculations. Ultimately, GOLDENSENS will investigate the enantiodiscriminating activity of prepared Au38 clusters towards methamphetamines, leading to the development of novel methods for enantiomeric separation. NMR-based techniques will quantify enantioselective interactions and 'absolute configuration modulation infrared spectroscopy' will clarify the mechanism of enantiodiscrimination by gold nanoclusters. Results and knowledge generated with GOLDENSENS will impact the understanding of chirality at the nanoscale, contributing to the growth of an emerging and frontier research field. The training provided by the project will help the experienced researcher to refine scientific and soft skills, ultimately acquiring all the abilities and competences necessary to start an independent academic career in nanotechnology.

Publications

List of publications.
year	authors and title	journal	last update
2019	Laura Riccardi, Federico De Biasi, Marco De Vivo, Thomas BÃ¼rgi, Federico Rastrelli, Giovanni Salassa Dynamic Origin of Chirality Transfer between Chiral Surface and Achiral Ligand in Au 38 Clusters published pages: 7127-7134, ISSN: 1936-0851, DOI: 10.1021/acsnano.9b02552	ACS Nano 13/6	2019-11-22
2019	Giovanni Salassa, Alessio Terenzi Metal Complexes of Oxadiazole Ligands: An Overview published pages: 3483, ISSN: 1422-0067, DOI: 10.3390/ijms20143483	International Journal of Molecular Sciences 20/14	2019-11-22
2019	Marta Diez-Castellnou, Giovanni Salassa, Fabrizio Mancin, Paolo Scrimin The Zn(II)-1,4,7-Trimethyl-1,4,7-Triazacyclononane Complex: A Monometallic Catalyst Active in Two Protonation States published pages: , ISSN: 2296-2646, DOI: 10.3389/fchem.2019.00469	Frontiers in Chemistry 7	2019-11-22

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The information about "GOLDENSENS" are provided by the European Opendata Portal: CORDIS opendata.