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NANOCANCER SIGNED

Getting new insights into the radio-sensitization effects of nanoparticles in photon and charged particle therapy

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

NANOCANCER project word cloud

Explore the words cloud of the NANOCANCER project. It provides you a very rough idea of what is the project "NANOCANCER" about.

first effect np combining glioma interaction advantage monte conventional deeper carlo effectiveness therapy spectroscopy framework diseases molecular full poor nanometre damages radiotherapy biological employed amplified vibrational complementary beams sensitizers nanocancer standard damage macromolecules shown strategy amplification fourier prognosis killing enhancement dose cellular clear therapeutic rt respect tumor transport breakthrough action au interdisciplinary microspectroscopy biochemical cell radiobiology infrared local particle gd nanoparticles realistic biology ftir tumour performing index simulation sensitization physical underlying time charged atomic purpose nano cells innovative mechanisms multidisciplinary light radio seems radiation enhanced transform photon insights substantially

Project "NANOCANCER" data sheet

The following table provides information about the project.

Coordinator	CONSORCIO PARA LA CONSTRUCCION EQUIPAMIENTO Y EXPLOTACION DEL LABORATORIO DE LUZ SINCROTRON Organization address address: CARRER DE LA LLUM 2-26 city: CERDANYOLA DEL VALLES BARCELONA postcode: 8290 website: http://www.cells.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Project website	https://www.cells.es/en/media/news/researchers-unveil-the-biochemical-effects-involved-in-nanoparticle-based-radiotherapy
Total cost	158˙121 €
EC max contribution	158˙121 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-SE
Starting year	2017
Duration (year-month-day)	from 2017-10-30 to 2019-10-29

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	CONSORCIO PARA LA CONSTRUCCION EQUIPAMIENTO Y EXPLOTACION DEL LABORATORIO DE LUZ SINCROTRON CONSORCIO PARA LA CONSTRUCCION EQUIPAMIENTO Y EXPLOTACION DEL LABORATORIO DE LUZ SINCROTRON Organization address address: CARRER DE LA LLUM 2-26 city: CERDANYOLA DEL VALLES BARCELONA postcode: 8290 website: http://www.cells.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (CERDANYOLA DEL VALLES BARCELONA)	coordinator	158˙121.00

Map

Project objective

The use of high-atomic-number nanoparticles (NP) as tumour radio-sensitizers has been recently proposed as a breakthrough in radiotherapy (RT). Numerous biological studies have shown the enhanced effectiveness in tumor cell killing when NP were associated to photon RT and, more recently, to charged particle therapy. However, the mechanisms of action are not clear yet. In addition to the damage due to a possible local dose enhancement (physical effects), the interaction of NP with essential biological macromolecules could lead to changes in the cells (biochemical effects) leading to an amplified effect of the radiation. Within this framework, the main goal of the NANOCANCER project is to get deeper insights into the mechanisms underlying the amplification of radiation effects of NP. For this purpose, I will use a multidisciplinary strategy to evaluate both the biochemical and physical effects involved in these innovative nano-RT approaches. Vibrational spectroscopy (Fourier transform infrared, FTIR, microspectroscopy) will be employed for the first time to investigate the biochemical features in glioma cells combining two high-Z standard nanoparticles (Au and Gd) and charged particle beams. Physical effects will be also assessed by performing complementary Monte Carlo simulation of radiation transport, which will allow a realistic modelling of early biological damages induced by the radiation at the nanometre scale. This interdisciplinary proposal will be essential to better characterize the radio-sensitization effects of NP in glioma cells and, in addition, will bring light to the present charged particle therapy radiobiology, which seems to lead to substantially different tumour responses with respect to conventional RT at the cellular and molecular level. The knowledge of these biochemical features will help researchers to develop RT by taking full advantage of the underlying biology an enhance the therapeutic index of RT for diseases with poor prognosis.

Publications

List of publications.
year	authors and title	journal	last update
2019	I. MartÃnez-Rovira, O. Seksek, I. Yousef A synchrotron-based infrared microspectroscopy study on the cellular response induced by gold nanoparticles combined with X-ray irradiations on F98 and U87-MG glioma cell lines published pages: 6352-6364, ISSN: 0003-2654, DOI: 10.1039/c9an01109a	The Analyst 144/21	2019-12-16
2019	Immaculada MartÃnez-Rovira, Olivier Seksek, Josep Puxeu, Joan GÃ³mez, Martin Kreuzer, Tanja DuÄiÄ‡, Maria Josep Ferreres, Manel Artigues, Ibraheem Yousef Synchrotron-based infrared microspectroscopy study on the radiosensitization effects of Gd nanoparticles at megavoltage radiation energies published pages: 5511-5520, ISSN: 0003-2654, DOI: 10.1039/C9AN00792J	The Analyst 144/18	2019-10-29

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