Opendata, web and dolomites

FocAd SIGNED

Structural Studies on Focal Adhesions

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 FocAd project word cloud

Explore the words cloud of the FocAd project. It provides you a very rough idea of what is the project "FocAd" about.

counteracting    points    aggressive    adhesions    super    cell    fundamental    transduce    employ    sensing    observe    microscopy    questions    medically    detrimental    defects    cells    structural    basis    biochemical    triggered    players    tension    living    developmental    function    initiating    innovative    fas    hence    macromolecular    molecular    leads    networks    cytoskeletons    components    sophisticated    techniques    assembly    unclear    ultrastructural    biology    reconstitutions    cytoskeleton    sensitive    cryo    actin    membranes    learned    signaling    biophysical    edge    contributes    lessons    ligand    force    activation    em    stepwise    environment    light    recombinant    crystallography    cutting    machinery    outside    systematic    survival    integrin    transferred    assemblies    hierarchical    complexes    fa    expertise    platform    core    tested    clarified    focal    cancers    behavior    mechanisms    governing    mass    regarding    emerged    fashion    protein    spectrometry    migration    hybrid    ray    purified    polarization    anchoring    tackle    implicated    combination    regulation    gigantic   

Project "FocAd" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: Munich
postcode: 80539
website: www.mpg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙999˙998 €
 EC max contribution 1˙999˙998 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-07-01   to  2022-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (Munich) coordinator 1˙999˙998.00

Map

 Project objective

Focal adhesions (FA) are gigantic protein complexes whose formation is triggered by integrin ligand activation. FAs represent (1) a sensing platform and anchoring points to the outside environment and, (2) a machinery to transduce this information by initiating signaling pathways for cell growth, survival, migration and polarization. Failure in the regulation of FA leads to developmental defects and contributes to the formation of aggressive cancers. Hence, understanding FA formation is the basis for counteracting these detrimental effects. Recently, mass spectrometry and advanced light microscopy clarified players involved in the FA assembly and implicated sophisticated regulation networks of membranes and actin cytoskeletons in the growth of FAs. However, the molecular mechanisms of FA formation and signaling still remain unclear. We propose to study the molecular mechanisms governing the growth of FA by bottom-up reconstitutions using purified recombinant protein components. We will employ a systematic and hierarchical assembly of the FA machinery on an integrin platform as well as on an actin cytoskeleton in a stepwise fashion. We will use a combination of cutting-edge techniques of hybrid structural biology (cryo-EM and X-ray crystallography), light microscopy and biochemical/biophysical approaches. Our core expertise is cryo-EM, which has emerged as the method of choice to study the molecular mechanisms of (super-)macromolecular assemblies. Furthermore, we will set up a system to observe the behavior of tension-sensitive FA components in the presence of force under cryo-EM. Finally, lessons learned from our biochemical and ultrastructural analysis will be directly transferred and tested in living cells. Using these innovative methods, we will tackle fundamental and medically relevant questions regarding the assembly and function of FAs.

 Publications

year authors and title journal last update
List of publications.
2019 Dirk Dedden, Stephanie Schumacher, Charlotte F. Kelley, Martin Zacharias, Christian Biertümpfel, Reinhard Fässler, Naoko Mizuno
The Architecture of Talin1 Reveals an Autoinhibition Mechanism
published pages: 120-131.e13, ISSN: 0092-8674, DOI: 10.1016/j.cell.2019.08.034
Cell 179/1 2019-12-17

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "FOCAD" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "FOCAD" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

RECON (2019)

Reprogramming Conformation by Fluorination: Exploring New Areas of Chemical Space

Read More  

MOBETA (2020)

Motor cortical beta bursts for movement planning and evaluation: Mechanisms, functional roles, and development

Read More  

DISSECT (2020)

DISSECT: Evidence in International Human Rights Adjudication

Read More