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Opendata, web and dolomites

PERISCOPE SIGNED

PERtussIS COrrelates of Protection Europe - Sofia ref.: 115910

Total Cost €

EC-Contrib. €

Partnership

Views

Outcomes and
results

PERISCOPE project word cloud

Explore the words cloud of the PERISCOPE project. It provides you a very rough idea of what is the project "PERISCOPE" about.

suggesting strategies industrialized pertussis internationally initiate reduce humans decade edge series vaccine pathogenesis incidence trials epidemiology innate acellular clinical additionally accompanied brings cutting bioinformatics successful immunology efpia evaluation countries disease expertise guide immunization differences vulnerable profile registration animal introduction techniques colonization protection adaptive vaccinated candidates accelerated biomarkers adolescents immunity older harmonized durable bp cell human constitutes circulation transmission infection scientific infrastructure ecosystem periscope standardized rebuild vaccines global last optimal unravel wane infants adults ap assays reactogenicity group microbiology innovation burden public shown vaccination molecular models risk reducing

Project "PERISCOPE" data sheet

The following table provides information about the project.

Coordinator	STICHTING KATHOLIEKE UNIVERSITEIT Organization address address: GEERT GROOTEPLEIN NOORD 9 city: NIJMEGEN postcode: 6525 EZ website: www.radboudumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	http://www.periscope-project.eu
Total cost	29˙926˙682 €
EC max contribution	21˙000˙000 € (70%)
Programme	1. H2020-EU.3.1.7. (Innovative Medicines Initiative 2 (IMI2))
Code Call	H2020-JTI-IMI2-2015-03-two-stage
Funding Scheme	IMI2-RIA
Starting year	2016
Duration (year-month-day)	from 2016-03-01 to 2021-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	STICHTING KATHOLIEKE UNIVERSITEIT STICHTING KATHOLIEKE UNIVERSITEIT Organization address address: GEERT GROOTEPLEIN NOORD 9 city: NIJMEGEN postcode: 6525 EZ website: www.radboudumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (NIJMEGEN)	coordinator	3˙701˙114.00
2	UNIVERSITY OF SOUTHAMPTON UNIVERSITY OF SOUTHAMPTON Organization address address: Highfield city: SOUTHAMPTON postcode: SO17 1BJ website: http://www.southampton.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SOUTHAMPTON)	participant	2˙561˙944.00
3	LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER Organization address address: KEPPEL STREET city: LONDON postcode: WC1E 7HT website: http://www.lshtm.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	2˙048˙455.00
4	RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU Organization address address: Antonie Van Leeuwenhoeklaan 9 city: BILTHOVEN postcode: 3721 MA website: www.rivm.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (BILTHOVEN)	participant	2˙021˙832.00
5	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Organization address address: WELLINGTON SQUARE UNIVERSITY OFFICES city: OXFORD postcode: OX1 2JD website: www.ox.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (OXFORD)	participant	1˙779˙999.00
6	COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES Organization address address: RUE LEBLANC 25 city: PARIS 15 postcode: 75015 website: www.cea.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS 15)	participant	1˙500˙243.00
7	ACADEMISCH ZIEKENHUIS LEIDEN ACADEMISCH ZIEKENHUIS LEIDEN Organization address address: ALBINUSDREEF 2 city: LEIDEN postcode: 2333 ZA website: www.lumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	1˙492˙500.00
8	TURUN YLIOPISTO TURUN YLIOPISTO Organization address address: YLIOPISTONMAKI city: Turku postcode: 20014 website: www.utu.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (Turku)	participant	1˙475˙000.00
9	INSTITUT PASTEUR DE LILLE FONDATION INSTITUT PASTEUR DE LILLE FONDATION Organization address address: RUE DU PROFESSEUR CALMETTE 1 city: LILLE postcode: 59019 website: http://www.pasteur-lille.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (LILLE)	participant	799˙998.00
10	THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN Organization address address: College Green city: DUBLIN postcode: 2 website: www.tcd.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN)	participant	650˙000.00
11	Department of Health Department of Health Organization address address: Quarry House, Quarry Hill city: Leeds postcode: LS2 7UE website: www.dh.gov.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (Leeds)	participant	564˙110.00
12	UNIVERSIDAD DE SALAMANCA UNIVERSIDAD DE SALAMANCA Organization address address: CALLE PATIO DE ESCUELAS 1 city: SALAMANCA postcode: 37008 website: www.usal.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (SALAMANCA)	participant	547˙500.00
13	EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH Organization address address: HEINRICH-HERTZ-ALLEE 1 city: ST INGBERT postcode: 66386 website: www.eurice.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (ST INGBERT)	participant	531˙250.00
14	UNIVERSITY OF BATH UNIVERSITY OF BATH Organization address address: CLAVERTON DOWN city: BATH postcode: BA2 7AY website: http://www.bath.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BATH)	participant	399˙455.00
15	MIKROBIOLOGICKY USTAV AV CR V.V.I MIKROBIOLOGICKY USTAV AV CR V.V.I Organization address address: VIDENSKA 1083 city: PRAHA 4 postcode: 142 00 website: http://www.biomed.cas.cz/mbu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (PRAHA 4)	participant	300˙000.00
16	UNIVERSITE LIBRE DE BRUXELLES UNIVERSITE LIBRE DE BRUXELLES Organization address address: AVENUE FRANKLIN ROOSEVELT 50 city: BRUXELLES postcode: 1050 website: www.ulb.ac.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BRUXELLES)	participant	299˙995.00
17	Q-BIOLOGICALS NV Q-BIOLOGICALS NV Organization address address: TECHNOLOGIEPARK 4 city: GENT postcode: 9052 website: www.q-biologicals.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (GENT)	participant	175˙097.00
18	IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ website: http://www.imperial.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	84˙380.00
19	UNITED KINGDOM RESEARCH AND INNOVATION UNITED KINGDOM RESEARCH AND INNOVATION Organization address address: POLARIS HOUSE NORTH STAR AVENUE city: SWINDON postcode: SN2 1FL website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SWINDON)	participant	67˙125.00
20	CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS Organization address address: RUE DU BUGNON 21 city: LAUSANNE postcode: 1011 website: www.chuv.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (LAUSANNE)	participant	0.00
21	GLAXOSMITHKLINE BIOLOGICALS SA GLAXOSMITHKLINE BIOLOGICALS SA Organization address address: RUE DE L INSTITUT 89 city: RIXENSART postcode: 1330 website: www.gskbio.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (RIXENSART)	participant	0.00
22	MEDICAL RESEARCH COUNCIL MEDICAL RESEARCH COUNCIL Organization address address: NORTH STAR AVENUE POLARIS HOUSE 2 FLOOR DAVID PHILLIPS BUILDING city: SWINDON postcode: SN2 1FL website: www.mrc.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SWINDON)	participant	0.00
23	SANOFI PASTEUR SA SANOFI PASTEUR SA Organization address address: Avenue Pont Pasteur, 2 city: LYON postcode: 69007 website: www.sanofipasteur.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (LYON)	participant	0.00
24	UNIVERSITAT BASEL UNIVERSITAT BASEL Organization address address: PETERSPLATZ 1 city: BASEL postcode: 4051 website: www.unibas.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BASEL)	participant	0.00

Map

Project objective

Pertussis vaccines have been very successful in reducing the global burden of pertussis-related disease. However, in the last decade there has been a rise in pertussis incidence, particularly in vaccinated adolescents and adults in industrialized countries. The increased circulation of B. pertussis (Bp) constitutes a risk for transmission to vulnerable infants and older adults. Additionally, immunity in humans has been shown to wane rapidly after immunization with pertussis vaccines, especially with acellular pertussis (aP) vaccines, suggesting that the improved reactogenicity profile of aP compared to whole cell pertussis vaccines, may be accompanied by differences in duration of immunity. The key objectives of PERISCOPE are to 1. identify biomarkers of protection against Bp colonization and diseaseÍ¾ 2. foster scientific innovation and rebuild the ecosystem and technical infrastructure needed in Europe to allow the future evaluation of novel pertussis vaccine candidates and 3. improve understanding of the pathogenesis of Bp infection and its potential impact on the recently observed changes in pertussis epidemiology. To reach these objectives, PERISCOPE brings together a selected group of internationally recognized public and EFPIA partners with strong expertise in clinical trials, immunology, molecular microbiology, human and animal challenge models and bioinformatics. We will initiate a series of (pre)clinical studies and develop harmonized human and animal challenge models, standardized assays and cutting-edge techniques to unravel the innate and adaptive responses to Bp. This will allow us to identify biomarkers of protection and durable immunity. PERISCOPE will thus facilitate the accelerated development and registration of novel pertussis vaccines and/or guide optimal use of vaccination strategies. The introduction of improved pertussis vaccines will help to reduce the global burden of pertussis.

Deliverables

List of deliverables.
External Project website	Websites, patent fillings, videos etc.	2020-02-20 17:22:05
Summary report on first plenary conference with key stakeholders	Documents, reports	2020-02-20 17:22:05
Dissemination toolkit	Other	2020-02-20 17:22:05
PERISCOPE position paper	Documents, reports	2020-02-20 17:22:05

Take a look to the deliverables list in detail: detailed list of PERISCOPE deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Mieszko M. Wilk, Lisa Borkner, Alicja Misiak, Lucy Curham, Aideen C. Allen, Kingston H. G. Mills Immunization with whole cell but not acellular pertussis vaccines primes CD4 T RM cells that sustain protective immunity against nasal colonization with Bordetella pertussis published pages: 169-185, ISSN: 2222-1751, DOI: 10.1080/22221751.2018.1564630	Emerging Microbes & Infections 8/1	2020-03-05
2019	Hans de Graaf, Muktar Ibrahim, Alison R Hill, Diane Gbesemete, Andrew T Vaughan, Andrew Gorringe, Andrew Preston, Annemarie M Buisman, Saul N Faust, Kent E Kester, Guy A M Berbers, Dimitri A Diavatopoulos, Robert C Read Controlled Human Infection With Bordetella pertussis Induces Asymptomatic, Immunizing Colonization published pages: , ISSN: 1058-4838, DOI: 10.1093/cid/ciz840	Clinical Infectious Diseases	2020-03-05
2017	Hans de Graaf, Diane Gbesemete, Andrew R. Gorringe, Dimitri A. Diavatopoulos, Kent E. Kester, Saul N. Faust, Robert C. Read Investigating Bordetella pertussis colonisation and immunity: protocol for an inpatient controlled human infection model published pages: e018594, ISSN: 2044-6055, DOI: 10.1136/bmjopen-2017-018594	BMJ Open 7/10	2020-02-20
2018	Lisa Borkner, Alicja Misiak, Mieszko M. Wilk, Kingston H. G. Mills Azithromycin Clears Bordetella pertussis Infection in Mice but Also Modulates Innate and Adaptive Immune Responses and T Cell Memory published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01764	Frontiers in Immunology 9	2020-02-20
2018	Thibaut Naninck, LoÃ¯c Coutte, CÃ©line Mayet, Vanessa Contreras, Camille Locht, Roger Le Grand, Catherine Chapon In vivo imaging of bacterial colonization of the lower respiratory tract in a baboon model of Bordetella pertussis infection and transmission published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-30896-7	Scientific Reports 8/1	2020-02-20
2018	Philippe Denoel, Patricia LondoÃ±o-Hayes, Magda Chlebus, Magdalena Rodriguez de Azero Impact of the Innovative Medicines Initiative on vaccine development published pages: 769-770, ISSN: 1474-1776, DOI: 10.1038/nrd.2018.72	Nature Reviews Drug Discovery 17/11	2020-02-20
2018	Dimitri A. Diavatopoulos, Kingston H.G. Mills, Kent E. Kester, Beate Kampmann, Marcela Silerova, Ulrich Heininger, Jacques J.M. van Dongen, Robbert G. van der Most, Martijn A. Huijnen, Emilio Siena, Nathalie Mielcarek, Martina M. Ochs, Philippe DenoÃ«l, Guy Berbers, Annemarie M. Buisman, Marien I. de Jonge, Craig Fenwick, Andrew Gorringe, Qiushui He, Dominic Kelly, Roger Le Grand, Camille Locht, FranÃ§oise Mascart, Jussi Mertsola, Alberto Orfao, Giuseppe Pantaleo, Andrew J. Pollard, Andrew Preston, Robert Read, Peter Sebo, Cecile van Els, Branislav Vecerek, Patricia LondoÃ±o-Hayes, Ronald de Groot PERISCOPE: road towards effective control of pertussis published pages: , ISSN: 1473-3099, DOI: 10.1016/s1473-3099(18)30646-7	The Lancet Infectious Diseases	2020-02-20

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The information about "PERISCOPE" are provided by the European Opendata Portal: CORDIS opendata.