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BEAt-DKD SIGNED

Biomarker Enterprise to Attack DKD - Sofia ref.: 115974

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

BEAt-DKD project word cloud

Explore the words cloud of the BEAt-DKD project. It provides you a very rough idea of what is the project "BEAt-DKD" about.

treatment underlying therapies goals predictive patient nephropathy cure targetable stages view biomarkers renal cohorts imaging cprobe vast acceptance epidemic reached prevent techniques disease few initiation tools kidneyconnect mechanisms understand diabetic summit patients stage sub alternative treatments kidney model medicine first unprecedented lack regulatory trials agencies introduction accurate leaders validate unfortunately tissue limited representing fp7 beat esrd networks precision global dkd stratification outstanding basic prevalence efficient diabetes jointly incidence imi1 syskid translational search classification holistic dimensions emerged stagnating effect biology combines clinical progression prognostic pathogenesis

Project "BEAt-DKD" data sheet

The following table provides information about the project.

Coordinator	LUNDS UNIVERSITET Organization address address: Paradisgatan 5c city: LUND postcode: 22100 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Sweden [SE]
Project website	http://www.beat-dkd.eu
Total cost	30˙163˙037 €
EC max contribution	15˙085˙937 € (50%)
Programme	1. H2020-EU.3.1.7. (Innovative Medicines Initiative 2 (IMI2))
Code Call	H2020-JTI-IMI2-2015-05-two-stage
Funding Scheme	IMI2-RIA
Starting year	2016
Duration (year-month-day)	from 2016-09-01 to 2021-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	LUNDS UNIVERSITET LUNDS UNIVERSITET Organization address address: Paradisgatan 5c city: LUND postcode: 22100 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (LUND)	coordinator	2˙110˙937.00
2	ACADEMISCH ZIEKENHUIS GRONINGEN ACADEMISCH ZIEKENHUIS GRONINGEN Organization address address: HANZEPLEIN 1 city: GRONINGEN postcode: 9713 GZ website: www.umcg.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (GRONINGEN)	participant	2˙100˙000.00
3	UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF Organization address address: Martinistrasse 52 city: HAMBURG postcode: 20251 website: www.uke.uni-hamburg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HAMBURG)	participant	1˙530˙000.00
4	MEDIZINISCHE UNIVERSITAET WIEN MEDIZINISCHE UNIVERSITAET WIEN Organization address address: SPITALGASSE 23 city: WIEN postcode: 1090 website: www.meduniwien.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	950˙000.00
5	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Organization address address: WELLINGTON SQUARE UNIVERSITY OFFICES city: OXFORD postcode: OX1 2JD website: www.ox.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (OXFORD)	participant	900˙000.00
6	MEDIZINISCHE UNIVERSITAT INNSBRUCK MEDIZINISCHE UNIVERSITAT INNSBRUCK Organization address address: CHRISTOPH PROBST PLATZ 1 city: INNSBRUCK postcode: 6020 website: www.i-med.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (INNSBRUCK)	participant	895˙000.00
7	UNIVERSITY OF LEEDS UNIVERSITY OF LEEDS Organization address address: WOODHOUSE LANE city: LEEDS postcode: LS2 9JT website: www.leeds.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LEEDS)	participant	860˙000.00
8	HELSINGIN YLIOPISTO HELSINGIN YLIOPISTO Organization address address: YLIOPISTONKATU 3 city: HELSINGIN YLIOPISTO postcode: 14 website: www.helsinki.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (HELSINGIN YLIOPISTO)	participant	800˙000.00
9	UNIVERSITY OF DUNDEE UNIVERSITY OF DUNDEE Organization address address: Nethergate city: DUNDEE postcode: DD1 4HN website: www.dundee.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (DUNDEE)	participant	655˙000.00
10	UNIVERSITA DEGLI STUDI DI BARI ALDO MORO UNIVERSITA DEGLI STUDI DI BARI ALDO MORO Organization address address: PIAZZA UMBERTO I 1 city: BARI postcode: 70121 website: www.uniba.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (BARI)	participant	620˙000.00
11	THE UNIVERSITY OF EXETER THE UNIVERSITY OF EXETER Organization address address: THE QUEEN'S DRIVE NORTHCOTE HOUSE city: EXETER postcode: EX4 4QJ website: www.ex.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EXETER)	participant	555˙000.00
12	UNIVERSITATSKLINIKUM ERLANGEN UNIVERSITATSKLINIKUM ERLANGEN Organization address address: MAXIMILIANSPLATZ 2 city: ERLANGEN postcode: 91054 website: www.uk-erlangen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (ERLANGEN)	participant	500˙000.00
13	UNIVERSITY OF BRISTOL UNIVERSITY OF BRISTOL Organization address address: BEACON HOUSE QUEENS ROAD city: BRISTOL postcode: BS8 1QU website: www.bristol.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BRISTOL)	participant	500˙000.00
14	CHU HOPITAUX DE BORDEAUX CHU HOPITAUX DE BORDEAUX Organization address address: RUE DUBERNAT 12 city: TALENCE postcode: 33404 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (TALENCE)	participant	460˙000.00
15	KLINIKUM DER UNIVERSITAET REGENSBURG KLINIKUM DER UNIVERSITAET REGENSBURG Organization address address: FRANS JOSEF STRAUSS ALLEE 11 city: REGENSBURG postcode: 93053 website: www-cgi.uni-regensburg.de/Klinik/Klinikum/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (REGENSBURG)	participant	360˙000.00
16	TURUN YLIOPISTO TURUN YLIOPISTO Organization address address: YLIOPISTONMAKI city: Turku postcode: 20014 website: www.utu.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (Turku)	participant	320˙000.00
17	LIPOTYPE LIPOTYPE Organization address address: TATZBERG 47 city: DRESDEN postcode: 1307 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DRESDEN)	participant	300˙000.00
18	UNIVERSITY OF HULL UNIVERSITY OF HULL Organization address address: COTTINGHAM ROAD city: HULL postcode: HU6 7RX website: www.hull.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (HULL)	participant	250˙000.00
19	ITA-SUOMEN YLIOPISTO ITA-SUOMEN YLIOPISTO Organization address address: YLIOPISTONRANTA 1 E city: KUOPIO postcode: 70211 website: www.uef.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (KUOPIO)	participant	200˙000.00
20	ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI Organization address address: VIA MARIO NEGRI 2 city: MILANO postcode: 20156 website: www.marionegri.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	150˙000.00
21	UNIVERSITAETSKLINIKUM FREIBURG UNIVERSITAETSKLINIKUM FREIBURG Organization address address: HUGSTETTER STRASSE 49 city: FREIBURG postcode: 79106 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (FREIBURG)	participant	70˙000.00
22	ABBVIE INC ABBVIE INC Organization address address: NORTH WAUKEGAN ROAD 1 city: NORTH CHICAGO IL postcode: 60064 website: www.abbvie.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (NORTH CHICAGO IL)	participant	0.00
23	ASTELLAS PHARMA EUROPE BV ASTELLAS PHARMA EUROPE BV Organization address address: SYLVIUSWEG 84 city: LEIDEN postcode: 2333 BE website: www.astellas.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	0.00
24	Bayer Pharma AG Bayer Pharma AG Organization address address: Muellerstrasse 178 city: Berlin postcode: 13353 website: www.bayerpharma.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Berlin)	participant	0.00
25	BOEHRINGER INGELHEIM INTERNATIONALGMBH BOEHRINGER INGELHEIM INTERNATIONALGMBH Organization address address: BINGER STRASSE city: INGELHEIM postcode: 55218 website: www.boehringerâ€ingelheim.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (INGELHEIM)	participant	0.00
26	Eli Lilly and Company Limited Eli Lilly and Company Limited Organization address address: Lilly House, Priestley Road city: Basingstoke postcode: RG24 9NL website: www.lilly.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (Basingstoke)	participant	0.00
27	JDRF INTERNATIONAL JDRF INTERNATIONAL Organization address address: 26 BROADWAY 14TH FLOOR city: NEW YORK postcode: 10004 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (NEW YORK)	participant	0.00
28	NOVO NORDISK A/S NOVO NORDISK A/S Organization address address: NOVO ALLE 1 city: BAGSVAERD postcode: 2880 website: www.novonordisk.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (BAGSVAERD)	participant	0.00
29	SANOFI-AVENTIS DEUTSCHLAND GMBH SANOFI-AVENTIS DEUTSCHLAND GMBH Organization address address: BRUNINGSTRASSE 50 city: FRANKFURT AM MAIN postcode: 65929 website: www.sanofi.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (FRANKFURT AM MAIN)	participant	0.00
30	SIB INSTITUT SUISSE DE BIOINFORMATIQUE SIB INSTITUT SUISSE DE BIOINFORMATIQUE Organization address address: RUE MICHEL SERVET 1 CMU city: GENEVE postcode: 1206 website: www.isb-sib.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (GENEVE)	participant	0.00
31	UNIVERSITY OF MICHIGAN THE REGENTS OF THE UNIVERSITY OF MICHIGAN UNIVERSITY OF MICHIGAN THE REGENTS OF THE UNIVERSITY OF MICHIGAN Organization address address: SOUTH STREET 3003 1068 city: ANN ARBOR postcode: 46109 1274 website: http://www.umich.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (ANN ARBOR)	participant	0.00

Map

Project objective

Diabetic kidney disease (DKD) is the leading cause of end stage renal disease (ESRD), and its global incidence and prevalence have reached epidemic dimensions in recent years. Unfortunately, there are no effective means to prevent or cure DKD, the few existing treatments have limited effect and very few alternative therapies have emerged in the past years. Lack of new predictive and prognostic biomarkers for a more accurate patient stratification, limited access to kidney tissue from patients at various stages of DKD as well as novel model systems to better understand the pathogenesis of the disease, are likely reasons for the stagnating development of new treatments.

The BEAt-DKD consortium combines outstanding basic and translational researchers in nephropathy, diabetes, kidney model systems, imaging techniques and systems biology, and includes leaders of diabetes and kidney disease-relevant IMI1, FP7 and US consortia, like SUMMIT, KIDNEYCONNECT, Syskid, CPROBE and C-Path, in an unprecedented search for new and better biomarkers for DKD, through a better understanding of the disease.

Jointly, the partners have access to vast and very relevant clinical cohorts and trials, state-of-the-art analysis and imaging techniques, novel model systems and the long-standing experience and networks to make this collaboration a success. By involving regulatory agencies throughout the project, BEAt-DKD aims at making the introduction and acceptance of new tools as efficient as possible.

The overall goals of BEAt-DKD are (1) to provide a holistic systems medicine view of the pathogenesis of DKD with the aim to identify targetable mechanisms and pathways underlying initiation and progression of DKD, applying a novel sub-classification of diabetes, and (2) to identify and validate biomarkers of disease progression and treatment responses representing first steps towards precision medicine in the management of DKD.

Deliverables

List of deliverables.
White paper on strengths and weaknesses of using biomarker panels (or multiple biomarker scores) as risk stratifiers, as targets in drug development and as surrogate endpoints for regulatory approval	Documents, reports	2020-04-08 21:02:42

Take a look to the deliverables list in detail: detailed list of BEAt-DKD deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Khalid Alyodawi, Wilbert P. Vermeij, Saleh Omairi, Oliver Kretz, Mark Hopkinson, Francesca Solagna, Barbara Joch, Renata M.C. Brandt, Sander Barnhoorn, Nicole Vliet, Yanto Ridwan, Jeroen Essers, Robert Mitchell, Taryn Morash, Arja Pasternack, Olli Ritvos, Antonios Matsakas, Henry Collinsâ€Hooper, Tobias B. Huber, Jan H.J. Hoeijmakers, Ketan Patel Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling published pages: 662-686, ISSN: 2190-5991, DOI: 10.1002/jcsm.12404	Journal of Cachexia, Sarcopenia and Muscle 10/3	2020-04-08
2019	Xiaomeng Xu, Karina Barreiro, Luca Musante, Oliver Kretz, Hanfei Lin, Hequn Zou, Tobias B. Huber, Harry Holthofer Management of Tammâ€“Horsfall Protein for Reliable Urinary Analytics published pages: 1900018, ISSN: 1862-8346, DOI: 10.1002/prca.201900018	PROTEOMICS â€“ Clinical Applications 13/6	2020-04-08
2019	Hiddo J. L. Heerspink, Paul Perco, Skander Mulder, Johannes Leierer, Michael K. Hansen, Andreas Heinzel, Gert Mayer Canagliflozin reduces inflammation and fibrosis biomarkers: a potential mechanism of action for beneficial effects of SGLT2 inhibitors in diabetic kidney disease published pages: 1154-1166, ISSN: 0012-186X, DOI: 10.1007/s00125-019-4859-4	Diabetologia 62/7	2020-04-08
2019	Paul T. Brinkkoetter, Tillmann Bork, Sarah Salou, Wei Liang, Athanasia Mizi, Cem Ã–zel, Sybille Koehler, H. Henning Hagmann, Christina Ising, Alexander Kuczkowski, Svenia Schnyder, Ahmed Abed, Bernhard Schermer, Thomas Benzing, Oliver Kretz, Victor G. Puelles, Simon Lagies, Manuel Schlimpert, Bernd Kammerer, Christoph Handschin, Christoph Schell, Tobias B. Huber Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics published pages: 1551-1566.e5, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2019.04.012	Cell Reports 27/5	2020-04-08
2019	Nienke M A Idzerda, Bergur V Stefansson, Michelle J Pena, David C Sjostrom, David C Wheeler, Hiddo J L Heerspink Prediction of the effect of dapagliflozin on kidney and heart failure outcomes based on short-term changes in multiple risk markers published pages: , ISSN: 0931-0509, DOI: 10.1093/ndt/gfz064	Nephrology Dialysis Transplantation	2020-04-08
2019	Pengyun Li, Hussein N. Rubaiy, Guiâ€Lan Chen, Thomas Hallett, Nawel Zaibi, Bo Zeng, Rahul Saurabh, Shangâ€Zhong Xu Mibefradil, a Tâ€type Ca 2+ channel blocker also blocks Orai channels by action at the extracellular surface published pages: 3845-3856, ISSN: 0007-1188, DOI: 10.1111/bph.14788	British Journal of Pharmacology 176/19	2020-04-08
2019	Christian Koppelstaetter, Johannes Leierer, Michael Rudnicki, Julia Kerschbaum, Andreas Kronbichler, Anette Melk, Gert Mayer, Paul Perco Computational Drug Screening Identifies Compounds Targeting Renal Age-associated Molecular Profiles published pages: 843-853, ISSN: 2001-0370, DOI: 10.1016/j.csbj.2019.06.019	Computational and Structural Biotechnology Journal 17	2020-04-08
2019	Michael Kammer, Andreas Heinzel, Jill A. Willency, Kevin L. Duffin, Gert Mayer, Kai Simons, Mathias J. Gerl, Christian Klose, Georg Heinze, Roman Reindl-Schwaighofer, Karin Hu, Paul Perco, Susanne Eder, Laszlo Rosivall, Patrick B. Mark, Wenjun Ju, Matthias Kretzler, Mark I. McCarthy, Hiddo L. Heerspink, Andrzej Wiecek, Maria F. Gomez, Rainer Oberbauer Integrative analysis of prognostic biomarkers derived from multiomics panels helps discrimination of chronic kidney disease trajectories in people with type 2 diabetes published pages: 1381-1388, ISSN: 0085-2538, DOI: 10.1016/j.kint.2019.07.025	Kidney International 96/6	2020-04-08
2019	Skander Mulder, Hiddo J. L. Heerspink, Manjula Darshi, Jiwan J. Kim, Gozewijn D. Laverman, Kumar Sharma, Michelle J. Pena Effects of dapagliflozin on urinary metabolites in people with type 2 diabetes published pages: 2422-2428, ISSN: 1462-8902, DOI: 10.1111/dom.13823	Diabetes, Obesity and Metabolism 21/11	2020-04-08
2019	Paul Perco, Wenjun Ju, Julia Kerschbaum, Johannes Leierer, Rajasree Menon, Catherine Zhu, Matthias Kretzler, Gert Mayer, Michael Rudnicki Identification of dicarbonyl and L-xylulose reductase as a therapeutic target in human chronic kidney disease published pages: , ISSN: 2379-3708, DOI: 10.1172/jci.insight.128120	JCI Insight 4/12	2020-04-08
2019	Francesca Conserva, Mariagrazia Barozzino, Francesco Pesce, Chiara Divella, Annarita Oranger, Massimo Papale, Fabio Sallustio, Simona Simone, Luigi Laviola, Francesco Giorgino, Anna Gallone, Paola Pontrelli, Loreto Gesualdo Urinary miRNA-27b-3p and miRNA-1228-3p correlate with the progression of Kidney Fibrosis in Diabetic Nephropathy published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-47778-1	Scientific Reports 9/1	2020-04-08
2017	Markus M. Rinschen, Florian Grahammer, Ann-Kathrin Hoppe, Priyanka Kohli, Henning Hagmann, Oliver Kretz, Sabine Bertsch, Martin HÃ¶hne, Heike GÃ¶bel, Malte P. Bartram, Rajesh Kumar Gandhirajan, Marcus KrÃ¼ger, Paul-Thomas Brinkkoetter, Tobias B. Huber, Martin Kann, Sara A. WickstrÃ¶m, Thomas Benzing, Bernhard Schermer YAP-mediated mechanotransduction determines the podocyteâ€™s response to damage published pages: eaaf8165, ISSN: 1937-9145, DOI: 10.1126/scisignal.aaf8165	Science Signaling 10/474	2020-04-08
2017	Christoph Schell, Manuel Rogg, Martina Suhm, Martin HelmstÃ¤dter, Dominik Sellung, Mako Yasuda-Yamahara, Oliver Kretz, Victoria KÃ¼ttner, Hani Suleiman, Laxmikanth Kollipara, RenÃ© P. Zahedi, Albert Sickmann, Stefan Eimer, Andrey S. Shaw, Albrecht Kramer-Zucker, Mariko Hirano-Kobayashi, Takaya Abe, Shinichi Aizawa, Florian Grahammer, BjÃ¶rn Hartleben, JÃ¶rn Dengjel, Tobias B. Huber The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier published pages: E4621-E4630, ISSN: 0027-8424, DOI: 10.1073/pnas.1617004114	Proceedings of the National Academy of Sciences 114/23	2020-04-08
2018	Dick de Zeeuw, Hiddo J L Heerspink, Meg Jardine, Vlado Perkovic Renal trials in diabetes need a platform: time for a global approach? published pages: 356-358, ISSN: 2213-8587, DOI: 10.1016/S2213-8587(17)30263-2	The Lancet Diabetes & Endocrinology 6/5	2020-04-08
2017	Bo Zeng, Gui-Lan Chen, Eliana Garcia-Vaz, Sunil Bhandari, Nikoleta Daskoulidou, Lisa M. Berglund, Hongni Jiang, Thomas Hallett, Lu-Ping Zhou, Li Huang, Zi-Hao Xu, Viji Nair, Robert G. Nelson, Wenjun Ju, Matthias Kretzler, Stephen L. Atkin, Maria F. Gomez, Shang-Zhong Xu ORAI channels are critical for receptor-mediated endocytosis of albumin published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-02094-y	Nature Communications 8/1	2020-04-08
2017	Markus M. Rinschen, Ann-Kathrin Hoppe, Florian Grahammer, Martin Kann, Linus A. VÃ¶lker, Eva-Maria Schurek, Julie Binz, Martin HÃ¶hne, Fatih Demir, Milena Malisic, Tobias B. Huber, Christine Kurschat, Jayachandran N. Kizhakkedathu, Bernhard Schermer, Pitter F. Huesgen, Thomas Benzing N-Degradomic Analysis Reveals a Proteolytic Network Processing the Podocyte Cytoskeleton published pages: 2867-2878, ISSN: 1046-6673, DOI: 10.1681/ASN.2016101119	Journal of the American Society of Nephrology 28/10	2020-04-08
2017	Stefan Zschiedrich, Tillmann Bork, Wei Liang, Nicola Wanner, Kristina Eulenbruch, Stefan Munder, BjÃ¶rn Hartleben, Oliver Kretz, Simon Gerber, Matias Simons, Amandine Viau, Martine Burtin, Changli Wei, Jochen Reiser, Nadja Herbach, Maria-Pia Rastaldi, Clemens D Cohen, Pierre-Louis Tharaux, Fabiola Terzi, Gerd Walz, Markus GÃ¶del, Tobias B Huber Targeting mTOR Signaling Can Prevent the Progression of FSGS published pages: 2144-2157, ISSN: 1046-6673, DOI: 10.1681/asn.2016050519	Journal of the American Society of Nephrology 28/7	2020-04-08
2018	Markus M. Rinschen, Markus GÃ¶del, Florian Grahammer, Stefan Zschiedrich, Martin HelmstÃ¤dter, Oliver Kretz, Mostafa Zarei, Daniela A. Braun, Sebastian Dittrich, Caroline Pahmeyer, Patricia Schroder, Carolin Teetzen, HeonYung Gee, Ghaleb Daouk, Martin Pohl, Elisa Kuhn, Bernhard Schermer, Victoria KÃ¼ttner, Melanie Boerries, Hauke Busch, Mario Schiffer, Carsten Bergmann, Marcus KrÃ¼ger, Friedhelm Hildebrandt, Joern Dengjel, Thomas Benzing, Tobias B. Huber A Multi-layered Quantitative InÂ Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes published pages: 2495-2508, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.04.059	Cell Reports 23/8	2020-04-08
2018	Habib Hamidi, Matthias Kretzler Systems biology approaches to identify disease mechanisms and facilitate targeted therapy in the management of glomerular disease published pages: 1, ISSN: 1062-4821, DOI: 10.1097/MNH.0000000000000446	Current Opinion in Nephrology and Hypertension	2020-04-08
2018	Mako Yasuda-Yamahara, Manuel Rogg, Kosuke Yamahara, Jasmin I. Maier, Tobias B. Huber, Christoph Schell AIF1L regulates actomyosin contractility and filopodial extensions in human podocytes published pages: e0200487, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0200487	PLOS ONE 13/7	2020-04-08
2018	Marcos Wolf, Anneloes de Boer, Kanishka Sharma, Peter Boor, Tim Leiner, Gere Sunder-Plassmann, Ewald Moser, Anna Caroli, Neil Peter Jerome Magnetic resonance imaging T1- and T2-mapping to assess renal structure and function: a systematic review and statement paper published pages: ii41-ii50, ISSN: 0931-0509, DOI: 10.1093/ndt/gfy198	Nephrology Dialysis Transplantation 33/suppl_2	2020-04-08
2018	Laura Rennert, Stefan Zschiedrich, Lukas Sandner, BjÃ¶rn Hartleben, Sanja Cicko, Cemil Korcan Ayata, Charlotte Meyer, Andreas Zech, Robert Zeiser, Tobias B. Huber, Marco Idzko, Florian Grahammer P2Y2R Signaling Is Involved in the Onset of Glomerulonephritis published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01589	Frontiers in Immunology 9	2020-04-08
2018	Nienke M.A. Idzerda, Michelle J. Pena, Hiddo J.L. Heerspink Personalized medicine in diabetic kidney disease published pages: 1, ISSN: 1062-4821, DOI: 10.1097/MNH.0000000000000447	Current Opinion in Nephrology and Hypertension	2020-04-08
2019	Paul Perco, Michelle Pena, Hiddo J.L. Heerspink, Gert Mayer Multimarker Panels in Diabetic Kidney Disease: The Way to Improved Clinical Trial Design and Clinical Practice? published pages: 212-221, ISSN: 2468-0249, DOI: 10.1016/j.ekir.2018.12.001	Kidney International Reports 4/2	2020-04-08
2017	Ben Mellows, Robert Mitchell, Manuela Antonioli, Oliver Kretz, David Chambers, Marie-Theres Zeuner, Bernd Denecke, Luca Musante, Durrgah L. Ramachandra, Florence Debacq-Chainiaux, Harry Holthofer, Barbara Joch, Steve Ray, Darius Widera, Anna L. David, Tobias B. Huber, Joern Dengjel, Paolo De Coppi, Ketan Patel Protein and Molecular Characterization of a Clinically Compliant Amniotic Fluid Stem Cell-Derived Extracellular Vesicle Fraction Capable of Accelerating Muscle Regeneration Through Enhancement of Angiogenesis published pages: 1316-1333, ISSN: 1547-3287, DOI: 10.1089/scd.2017.0089	Stem Cells and Development 26/18	2020-04-08
2017	Luca Musante, Dorota Tataruch-Weinert, Dontscho Kerjaschki, Michael Henry, Paula Meleady, Harry Holthofer Residual urinary extracellular vesicles in ultracentrifugation supernatants after hydrostatic filtration dialysis enrichment published pages: 1267896, ISSN: 2001-3078, DOI: 10.1080/20013078.2016.1267896	Journal of Extracellular Vesicles 6/1	2020-04-08
2018	Nienke M A Idzerda, Michelle J Pena, Hans-Henrik Parving, Dick de Zeeuw, Hiddo J L Heerspink Proteinuria and cholesterol reduction are independently associated with less renal function decline in statin-treated patients; apost hoc analysis of the PLANET trials published pages: , ISSN: 0931-0509, DOI: 10.1093/ndt/gfy159	Nephrology Dialysis Transplantation	2020-04-08
2018	Paul Perco, Gert Mayer Endogenous factors and mechanisms of renoprotection and renal repair published pages: e12914, ISSN: 0014-2972, DOI: 10.1111/eci.12914	European Journal of Clinical Investigation 48/5	2020-04-08
2018	Nienke M. A. Idzerda, Frederik Persson, Michelle J. Pena, Barry M. Brenner, Patrick Brunel, Nish Chaturvedi, John J. McMurray, Hans-Henrik Parving, Dick de Zeeuw, Hiddo J. L. Heerspink N-terminal pro-brain natriuretic peptide (NT-proBNP) predicts the cardio-renal response to aliskiren in patients with type 2 diabetes at high renal and cardiovascular risk published pages: , ISSN: 1462-8902, DOI: 10.1111/dom.13465	Diabetes, Obesity and Metabolism	2020-04-08
2018	Skander Mulder, Habib Hamidi, Matthias Kretzler, Wenjun Ju An integrative systems biology approach for precision medicine in diabetic kidney disease published pages: 6-13, ISSN: 1462-8902, DOI: 10.1111/dom.13416	Diabetes, Obesity and Metabolism 20	2020-04-08
2018	Martin HÃ¶hne, Christian K. Frese, Florian Grahammer, Claudia Dafinger, Giuliano Ciarimboli, Linus Butt, Julia Binz, Matthias J. Hackl, Mahdieh Rahmatollahi, Martin Kann, Simon Schneider, Mehmet M. Altintas, Bernhard Schermer, Thomas Reinheckel, Heike GÃ¶bel, Jochen Reiser, Tobias B. Huber, Rafael Kramann, Tamina Seeger-Nukpezah, Max C. Liebau, Bodo B. Beck, Thomas Benzing, Andreas Beyer, Markus M. Rinschen Single-nephron proteomes connect morphology and function in proteinuric kidney disease published pages: 1308-1319, ISSN: 0085-2538, DOI: 10.1016/j.kint.2017.12.012	Kidney International 93/6	2020-04-08
2017	Martin HelmstÃ¤dter, Tobias B. Huber, Tobias Hermle Using the Drosophila Nephrocyte to Model Podocyte Function and Disease published pages: , ISSN: 2296-2360, DOI: 10.3389/fped.2017.00262	Frontiers in Pediatrics 5	2020-04-08
2018	Emma Ahlqvist, Petter Storm, Annemari KÃ¤rÃ¤jÃ¤mÃ¤ki, Mats Martinell, Mozhgan Dorkhan, Annelie Carlsson, Petter Vikman, Rashmi B Prasad, Dina Mansour Aly, Peter Almgren, Ylva Wessman, Nael Shaat, Peter SpÃ©gel, Hindrik Mulder, Eero Lindholm, Olle Melander, Ola Hansson, Ulf Malmqvist, Ã…ke Lernmark, Kaj Lahti, Tom ForsÃ©n, Tiinamaija Tuomi, Anders H Rosengren, Leif Groop Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables published pages: 361-369, ISSN: 2213-8587, DOI: 10.1016/S2213-8587(18)30051-2	The Lancet Diabetes & Endocrinology 6/5	2020-04-08
2017	Adeera Levin, Marcello Tonelli, Joseph Bonventre, Josef Coresh, Jo-Ann Donner, Agnes B Fogo, Caroline S Fox, Ron T Gansevoort, Hiddo J L Heerspink, Meg Jardine, Bertram Kasiske, Anna KÃ¶ttgen, Matthias Kretzler, Andrew S Levey, Valerie A Luyckx, Ravindra Mehta, Orson Moe, Gregorio Obrador, Neesh Pannu, Chirag R Parikh, Vlado Perkovic, Carol Pollock, Peter Stenvinkel, Katherine R Tuttle, David C Wheeler, Kai-Uwe Eckardt, Dwomoa Adu, Sanjay Kumar Agarwal, Mona Alrukhaimi, Hans-Joachim Anders, Gloria Ashuntantang, Shakti Basnet, Aminu K. Bello, Worawon Chailimpamontree, Ricardo Correa-Rotter, Jonathan Craig, Walter G. Douthat, Harold I. Feldman, Mohammad Reza Ganji, Guillermo Garcia-Garcia, Mohammed Benghanem Gharbi, David C. Harris, Vivekanand Jha, David W. Johnson, Rumeyza Kazancioglu, Robyn Langham, Zhi-Hong Liu, Ziad A. Massy, Masaomi Nangaku, Robert G. Nelson, Donal O\'Donoghue, Ikechi Okpechi, Roberto Pecoits-Filho, Neil R. Powe, Giuseppe Remuzzi, Charlotte Roberts, Jerome Rossert, Laura Sola, Benedicte Stengel, Ernest K. Sumaili M, Yusuke Suzuki, Tetsuhiro Tanaka, Sajja Tatiyanupanwong, Bernadette Thomas, Katrin Uhlig, Robert Walker, Sarah L. White, Andrzej Wiecek, Chih-Wei Yang Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy published pages: 1888-1917, ISSN: 0140-6736, DOI: 10.1016/S0140-6736(17)30788-2	The Lancet 390/10105	2020-04-08
2017	Sumra Nazir, Ihsan Gadi, Mohâ€™d Mohanad Al-Dabet, Ahmed Elwakiel, Shrey Kohli, Sanchita Ghosh, Jayakumar Manoharan, Satish Ranjan, Fabian Bock, Ruediger C. Braun-Dullaeus, Charles T. Esmon, Tobias B. Huber, Eric Camerer, Chris Dockendorff, John H. Griffin, Berend Isermann, Khurrum Shahzad Cytoprotective activated protein C averts Nlrp3 inflammasomeâ€“induced ischemia-reperfusion injury via mTORC1 inhibition published pages: 2664-2677, ISSN: 0006-4971, DOI: 10.1182/blood-2017-05-782102	Blood 130/24	2020-04-08
2018	Nicola Wanner, Julia Vornweg, Alexander Combes, Sean Wilson, Julia Plappert, Gesa Rafflenbeul, Victor G. Puelles, Raza-Ur Rahman, Timur Liwinski, Saskia Lindner, Florian Grahammer, Oliver Kretz, Mary E. Wlodek, Tania Romano, Karen M. Moritz, Melanie Boerries, Hauke Busch, Stefan Bonn, Melissa H. Little, Wibke Bechtel-Walz, Tobias B. Huber DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation published pages: 63-78, ISSN: 1046-6673, DOI: 10.1681/asn.2018070736	Journal of the American Society of Nephrology 30/1	2020-04-08
2018	Christoph Schell, Benedikt Sabass, Martin Helmstaedter, Felix Geist, Ahmed Abed, Mako Yasuda-Yamahara, August Sigle, Jasmin I. Maier, Florian Grahammer, Florian Siegerist, Nadine Artelt, Nicole Endlich, Dontscho Kerjaschki, Hans-Henning Arnold, JÃ¶rn Dengjel, Manuel Rogg, Tobias B. Huber ARP3 Controls the Podocyte Architecture at the Kidney Filtration Barrier published pages: 741-757.e8, ISSN: 1534-5807, DOI: 10.1016/j.devcel.2018.11.011	Developmental Cell 47/6	2020-04-08
2018	Sara GonÃ§alves, Julie Patat, Maria Clara Guida, Noelle LachaussÃ©e, Christelle Arrondel, Martin HelmstÃ¤dter, Olivia Boyer, Olivier Gribouval, Marie-Claire Gubler, Geraldine Mollet, MarlÃ¨ne Rio, Marina Charbit, Christine Bole-Feysot, Patrick Nitschke, Tobias B. Huber, Patricia G. Wheeler, Devon Haynes, Jane Juusola, Thierry Billette de Villemeur, Caroline Nava, Alexandra Afenjar, Boris Keren, Rolf Bodmer, Corinne Antignac, Matias Simons A homozygous KAT2B variant modulates the clinical phenotype of ADD3 deficiency in humans and flies published pages: e1007386, ISSN: 1553-7404, DOI: 10.1371/journal.pgen.1007386	PLOS Genetics 14/5	2020-04-08
2017	Karina Barreiro, Harry Holthofer Urinary extracellular vesicles. A promising shortcut to novel biomarker discoveries published pages: 217-227, ISSN: 0302-766X, DOI: 10.1007/s00441-017-2621-0	Cell and Tissue Research 369/1	2020-04-08
2018	Nicholas M Selby, Peter J Blankestijn, Peter Boor, Christian Combe, Kai-Uwe Eckardt, Eli Eikefjord, Nuria Garcia-Fernandez, Xavier Golay, Isky Gordon, Nicolas Grenier, Paul D Hockings, Jens D Jensen, Jaap A Joles, Philip A Kalra, Bernhard K KrÃ¤mer, Patrick B Mark, Iosif A Mendichovszky, Olivera Nikolic, Aghogho Odudu, Albert C M Ong, Alberto Ortiz, Menno Pruijm, Giuseppe Remuzzi, Jarle RÃ¸rvik, Sophie de Seigneux, Roslyn J Simms, Janka Slatinska, Paul Summers, Maarten W Taal, Harriet C Thoeny, Jean-Paul VallÃ©e, Marcos Wolf, Anna Caroli, Steven Sourbron Magnetic resonance imaging biomarkers for chronic kidney disease: a position paper from the European Cooperation in Science and Technology Action PARENCHIMA published pages: ii4-ii14, ISSN: 0931-0509, DOI: 10.1093/ndt/gfy152	Nephrology Dialysis Transplantation 33/suppl_2	2020-04-08
2018	Hiddo J. L. Heerspink, James List, Vlado Perkovic New clinical trial designs for establishing drug efficacy and safety in a precision medicine era published pages: 14-18, ISSN: 1462-8902, DOI: 10.1111/dom.13417	Diabetes, Obesity and Metabolism 20	2020-04-08
2017	Maja T. Lindenmeyer, Matthias Kretzler Renal biopsy-driven molecular target identification in glomerular disease published pages: 1021-1028, ISSN: 0031-6768, DOI: 10.1007/s00424-017-2006-y	PflÃ¼gers Archiv - European Journal of Physiology 469/7-8	2020-04-08
2018	Amandine Viau, Frank BienaimÃ©, Kamile Lukas, Abhijeet P Todkar, Manuel Knoll, Toma A Yakulov, Alexis Hofherr, Oliver Kretz, Martin HelmstÃ¤dter, Wilfried Reichardt, Simone Braeg, Tom Aschman, Annette Merkle, Dietmar Pfeifer, VerÃ³nica I Dumit, Marieâ€Claire Gubler, Roland Nitschke, Tobias B Huber, Fabiola Terzi, JÃ¶rn Dengjel, Florian Grahammer, Michael KÃ¶ttgen, Hauke Busch, Melanie Boerries, Gerd Walz, Antigoni Triantafyllopoulou, E Wolfgang Kuehn Ciliaâ€localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney published pages: e98615, ISSN: 0261-4189, DOI: 10.15252/embj.201798615	The EMBO Journal 37/15	2020-04-08
2018	Hans-Joachim Anders, Tobias B. Huber, Berend Isermann, Mario Schiffer CKD in diabetes: diabetic kidney disease versus nondiabetic kidney disease published pages: 361-377, ISSN: 1759-5061, DOI: 10.1038/s41581-018-0001-y	Nature Reviews Nephrology 14/6	2020-04-08
2018	Banaja P. Dash, Tina M. SchnÃ¶der, Carolin Kathner, Juliane Mohr, SÃ¶nke Weinert, Carolin Herzog, Parimala Sonika Godavarthy, Costanza Zanetti, Florian Perner, RÃ¼diger Braun-Dullaeus, BjÃ¶rn Hartleben, Tobias B. Huber, Gerd Walz, Michael Naumann, Sarah Ellis, Valera Vasioukhin, Thilo KÃ¤hne, Daniela S. Krause, Florian H. Heidel Diverging impact of cell fate determinants Scrib and Llgl1 on adhesion and migration of hematopoietic stem cells published pages: 1933-1944, ISSN: 0171-5216, DOI: 10.1007/s00432-018-2724-3	Journal of Cancer Research and Clinical Oncology 144/10	2020-04-08
2018	Kathryn L. Garner, Virginie M. S. Betin, Vanda Pinto, Mark Graham, Emmanuelle Abgueguen, Matt Barnes, David C. Bedford, Craig A. McArdle, Richard J. M. Coward Enhanced insulin receptor, but not PI3K, signalling protects podocytes from ER stress published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-22233-9	Scientific Reports 8/1	2020-04-08
2018	Ellen M. Apperloo, Michelle J. Pena, Dick de Zeeuw, Petra Denig, Hiddo J. L. Heerspink Individual variability in response to renin angiotensin aldosterone system inhibition predicts cardiovascular outcome in patients with type 2 diabetes: A primary care cohort study published pages: 1377-1383, ISSN: 1462-8902, DOI: 10.1111/dom.13226	Diabetes, Obesity and Metabolism 20/6	2020-04-08
2017	Carole Henique, Guillaume BollÃ©e, Xavier Loyer, Florian Grahammer, Neeraj Dhaun, Marine Camus, Julien Vernerey, LÃ©a Guyonnet, FranÃ§ois Gaillard, HÃ©lÃ¨ne Lazareth, Charlotte Meyer, Imane Bensaada, Luc LegrÃ¨s, Takashi Satoh, Shizuo Akira, Patrick Bruneval, Stefanie Dimmeler, Alain Tedgui, Alexandre Karras, Eric Thervet, Dominique Nochy, Tobias B. Huber, Laurent Mesnard, Olivia Lenoir, Pierre-Louis Tharaux Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-01885-7	Nature Communications 8/1	2020-04-08
2017	Matthew D. Breyer, Matthias Kretzler Novel avenues for drug discovery in diabetic kidney disease published pages: 65-74, ISSN: 1746-0441, DOI: 10.1080/17460441.2018.1398731	Expert Opinion on Drug Discovery 13/1	2020-04-08
2018	Hiddo J. L. Heerspink, Dick de Zeeuw Treating diabetic complications; from large randomized clinical trials to precision medicine published pages: 3-5, ISSN: 1462-8902, DOI: 10.1111/dom.13418	Diabetes, Obesity and Metabolism 20	2020-04-08
2019	J. A. Hurcombe, P. Hartley, A. C. Lay, L. Ni, J. J. Bedford, J. P. Leader, S. Singh, A. Murphy, C. L. Scudamore, E. Marquez, A. F. Barrington, V. Pinto, M. Marchetti, L.-F. Wong, J. Uney, M. A. Saleem, P. W. Mathieson, S. Patel, R. J. Walker, J. R. Woodgett, S. E. Quaggin, G. I. Welsh, R. J. M. Coward Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-08235-1	Nature Communications 10/1	2020-04-08
2018	Paul Perco, Gert Mayer Molecular, histological, and clinical phenotyping of diabetic nephropathy: valuable complementary information? published pages: 308-310, ISSN: 0085-2538, DOI: 10.1016/j.kint.2017.10.026	Kidney International 93/2	2020-04-08
2017	M. Rogg, M. Yasuda-Yamahara, A. Abed, P. Dinse, M. HelmstÃ¤dter, A. C. Conzelmann, J. Frimmel, D. Sellung, M. L. Biniossek, O. Kretz, F. Grahammer, O. Schilling, T. B. Huber, C. Schell The WD40-domain containing protein CORO2B is specifically enriched in glomerular podocytes and regulates the ventral actin cytoskeleton published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-15844-1	Scientific Reports 7/1	2020-04-08
2018	Andreas Heinzel, Michael Kammer, Gert Mayer, Roman Reindl-Schwaighofer, Karin Hu, Paul Perco, Susanne Eder, Laszlo Rosivall, Patrick B. Mark, Wenjun Ju, Matthias Kretzler, Peter Gilmour, Jonathan M. Wilson, Kevin L. Duffin, Moustafa Abdalla, Mark I. McCarthy, Georg Heinze, Hiddo L. Heerspink, Andrzej Wiecek, Maria F. Gomez, Rainer Oberbauer Validation of Plasma Biomarker Candidates for the Prediction of eGFR Decline in Patients With Type 2 Diabetes published pages: 1947-1954, ISSN: 0149-5992, DOI: 10.2337/dc18-0532	Diabetes Care 41/9	2020-04-08
2017	Abigail C. Lay, Jenny A. Hurcombe, Virginie M. S. Betin, Fern Barrington, Ruth Rollason, Lan Ni, Lawrence Gillam, Grace M. E. Pearson, Mette V. Ã˜stergaard, Hellyeh Hamidi, Rachel Lennon, Gavin I. Welsh, Richard J. M. Coward Prolonged exposure of mouse and human podocytes to insulin induces insulin resistance through lysosomal and proteasomal degradation of the insulin receptor published pages: 2299-2311, ISSN: 0012-186X, DOI: 10.1007/s00125-017-4394-0	Diabetologia 60/11	2020-04-08

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The information about "BEAT-DKD" are provided by the European Opendata Portal: CORDIS opendata.

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