Explore the words cloud of the MechaniChiral project. It provides you a very rough idea of what is the project "MechaniChiral" about.
The following table provides information about the project.
Coordinator |
UNIVERSITY OF SOUTHAMPTON
Organization address contact info |
Coordinator Country | United Kingdom [UK] |
Total cost | 1˙998˙927 € |
EC max contribution | 1˙998˙927 € (100%) |
Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
Code Call | ERC-2016-COG |
Funding Scheme | ERC-COG |
Starting year | 2017 |
Duration (year-month-day) | from 2017-04-01 to 2022-03-31 |
Take a look of project's partnership.
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1 | UNIVERSITY OF SOUTHAMPTON | UK (SOUTHAMPTON) | coordinator | 1˙998˙927.00 |
Molecular chirality is a central theme in chemistry; in 2015 approximately 13% of publications in J. Am. Chem. Soc. and 12% in Angew. Chem. concerned chirality. All previously studied forms of molecular asymmetry (central, axial, planar and helical chirality) have found applications throughout the sub-disciplines of chemistry including as catalysts, materials and sensors.
Mechanically chiral rotaxanes are molecules in which the mechanical bond between a macrocycle and dumbbell-shaped component is the source of asymmetry rather than the covalent structure of the components themselves. These unusual molecules represent a novel and unexplored chiral supramolecular environment as the lack of a scalable synthetic approach for their isolation in enantiopure form has prevented all but the most cursory investigation of their properties. Thus, mechanical chirality remains an unexplored frontier of molecular asymmetry with the potential to deliver novel functions and impact across a range of chemical disciplines from materials chemistry to the synthesis of pharmaceutically active compounds.
The Goldup Group has recently demonstrated the first practical method for the synthesis of enantiopure mechanically chiral rotaxanes using a flexible active template methodology and thus the stage is finally set for the study and exploitation of this novel form of supramolecular asymmetry. Within the period of this ERC Consolidator Grant the PI will lead a team to investigate the synthesis, properties and applications of these intriguing mechanically chiral molecules.
year | authors and title | journal | last update |
---|---|---|---|
2019 |
Florian Modicom, Ellen M. G. Jamieson, Elise Rochette, Stephen M. Goldup Chemical Consequences of the Mechanical Bond: A Tandem Active Template-Rearrangement Reaction published pages: 3875-3879, ISSN: 1433-7851, DOI: 10.1002/anie.201813950 |
Angewandte Chemie International Edition 58/12 | 2019-12-16 |
2019 |
Mathieu Denis, James E.M. Lewis, Florian Modicom, Stephen M. Goldup An Auxiliary Approach for the Stereoselective Synthesis of Topologically Chiral Catenanes published pages: 1512-1520, ISSN: 2451-9294, DOI: 10.1016/j.chempr.2019.03.008 |
Chem 5/6 | 2019-12-16 |
2018 |
Mathieu Denis, Stephen Michael Goldup A [3]Rotaxane Host Selects Between Stereoisomers published pages: 4462-4464, ISSN: 1433-7851, DOI: 10.1002/anie.201800665 |
Angewandte Chemie International Edition 57/17 | 2019-12-16 |
2019 |
Martina Cirulli, Amanpreet Kaur, James E. M. Lewis, Zhihui Zhang, Jonathan A. Kitchen, Stephen M. Goldup, Maxie M. Roessler Rotaxane-Based Transition Metal Complexes: Effect of the Mechanical Bond on Structure and Electronic Properties published pages: 879-889, ISSN: 0002-7863, DOI: 10.1021/jacs.8b09715 |
Journal of the American Chemical Society 141/2 | 2019-12-16 |
2018 |
Mathieu Denis, Jessica Pancholi, Kajally Jobe, Michael Watkinson, Stephen M. Goldup Chelating Rotaxane Ligands as Fluorescent Sensors for Metal Ions published pages: 5408-5412, ISSN: 0044-8249, DOI: 10.1002/ange.201712931 |
Angewandte Chemie 130/19 | 2019-12-16 |
2019 |
Ellen M. G. Jamieson, Stephen M. Goldup Chirality makes a move published pages: 765-767, ISSN: 1755-4330, DOI: 10.1038/s41557-019-0320-z |
Nature Chemistry 11/9 | 2019-12-16 |
2018 |
Valentina Bleve, Paola Franchi, Evangelia Konstanteli, Lorenzo Gualandi, Stephen M. Goldup, Elisabetta Mezzina, Marco Lucarini Synthesis and Characterisation of a Paramagnetic [2]Rotaxane Based on a Crown Ether-Like Wheel Incorporating a Nitroxide Motif published pages: 1198-1203, ISSN: 0947-6539, DOI: 10.1002/chem.201704969 |
Chemistry - A European Journal 24/5 | 2019-12-16 |
2017 |
T. H. Ngo, J. Labuta, G. N. Lim, W. A. Webre, F. D\'Souza, P. A. Karr, J. E. M. Lewis, J. P. Hill, K. Ariga, S. M. Goldup Porphyrinoid rotaxanes: building a mechanical picket fence published pages: 6679-6685, ISSN: 2041-6520, DOI: 10.1039/c7sc03165c |
Chemical Science 8/9 | 2019-05-15 |
2018 |
James E. M. Lewis, Florian Modicom, Stephen M. Goldup Efficient Multicomponent Active Template Synthesis of Catenanes published pages: 4787-4791, ISSN: 0002-7863, DOI: 10.1021/jacs.8b01602 |
Journal of the American Chemical Society 140/14 | 2019-05-15 |
2018 |
Mathieu Denis, Lei Qin, Peter Turner, Katrina A. Jolliffe, Stephen M. Goldup A Fluorescent Ditopic Rotaxane Ion-Pair Host published pages: 5315-5319, ISSN: 1433-7851, DOI: 10.1002/anie.201713105 |
Angewandte Chemie International Edition 57/19 | 2019-05-15 |
2018 |
E. M. G. Jamieson, F. Modicom, S. M. Goldup Chirality in rotaxanes and catenanes published pages: 5266-5311, ISSN: 0306-0012, DOI: 10.1039/c8cs00097b |
Chemical Society Reviews 47/14 | 2019-05-15 |
2018 |
Mathieu Denis, Jessica Pancholi, Kajally Jobe, Michael Watkinson, Stephen M. Goldup Chelating Rotaxane Ligands as Fluorescent Sensors for Metal Ions published pages: 5310-5314, ISSN: 1433-7851, DOI: 10.1002/anie.201712931 |
Angewandte Chemie International Edition 57/19 | 2019-05-15 |
2018 |
Michael A. Jinks, Alberto de Juan, Mathieu Denis, Catherine J. Fletcher, Marzia Galli, Ellen M. G. Jamieson, Florian Modicom, Zhihui Zhang, Stephen M. Goldup Stereoselective Synthesis of Mechanically Planar Chiral Rotaxanes published pages: 14806-14810, ISSN: 1433-7851, DOI: 10.1002/anie.201808990 |
Angewandte Chemie International Edition 57/45 | 2019-05-15 |
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The information about "MECHANICHIRAL" are provided by the European Opendata Portal: CORDIS opendata.
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