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REBUILD

Mechanisms of sarcomeric protein homeostasis during physical exercise and ageing

Total Cost €

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EC-Contrib. €

0

Partnership

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 REBUILD project word cloud

Explore the words cloud of the REBUILD project. It provides you a very rough idea of what is the project "REBUILD" about.

spectrometry    ultimately    life    host    society    independence    proteins    genetics    integrate    maintenance    genetic    mass    usa    researcher    biology    coordinated    quantify    damaged    homeostasis    flight    decline    mechanisms    francisco    line    movements    expertise    combining    physiological    physical    expand    ageing    establishing    free    san    create    constantly    silac    candidate    degenerate    dynamics    ing    interventions    turnover    rebuild    during    stepping    acquired    delay    progressive    mechanical    subjected    replacement    hypothesis    power    developmental    crossroads    vivo    function    exercise    scientific    stone    biomechanics    fiber    force    protein    forces    temporal    suboptimal    benefit    capacity    regulation    fibers    animal    proteomics    cells    generation    dynamic    training    position    discovery    homeostatic    elderly    individuals    muscle    health    consequence    nature    leads    quantitative    precise    driving    healthy    tissue    biomechanical    screen    orientated    interdisciplinary    accurately    western    stress    population    older    lack   

Project "REBUILD" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website http://muscledynamics.org/
 Total cost 185˙076 €
 EC max contribution 141˙203 € (76%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2019-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 141˙203.00

Map

 Project objective

During ageing muscle fibers are constantly subjected to high forces resulting in mechanical stress on cells and proteins. As a consequence they can degenerate, leading to suboptimal force generation, lack of coordinated movements and ultimately to muscle failure in the elderly population. This ageing process that leads to a progressive loss of muscle function has a major health impact on the ageing Western society. Physical activity is known to delay this decline.

The REBUILD project aims to determine the temporal dynamics of protein replacement during life of a muscle fiber by SILAC-based mass spectrometry and genetics. It will integrate biomechanics with muscle homeostasis and accurately quantify the impact of physical activity on protein turnover and investigate the physiological consequences for the ageing animal. By combining the power of genetics and SILAC-based proteomics with behaviour of free flight under defined exercise conditions, we create a unique position for a discovery orientated large-scale in vivo genetic screen. The interdisciplinary nature of the project will allow establishing novel hypothesis, combining muscle biomechanics as a driving force behind dynamic maintenance of the muscle tissue during ageing.

The experienced researcher will expand on previous training acquired in San Francisco, USA, and establish a new line of research in the crossroads of two developing fields (quantitative proteomics and biomechanical regulation of tissue homeostasis). This will be a stepping stone for his scientific independence. The host will expand on its expertise on developmental regulation of muscle formation and benefit from the expertise of the candidate in the biology of ageing and homeostasis.

A precise understanding of mechanisms that control homeostatic replacement of damaged proteins in muscle fibers should foster interventions aimed at maintenance of muscle capacity in older individuals and thus, an important step towards healthy ageing.

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The information about "REBUILD" are provided by the European Opendata Portal: CORDIS opendata.

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