Explore the words cloud of the PCELLS project. It provides you a very rough idea of what is the project "PCELLS" about.
The following table provides information about the project.
Coordinator |
UNIVERSITY OF BRISTOL
Organization address contact info |
Coordinator Country | United Kingdom [UK] |
Total cost | 2˙499˙238 € |
EC max contribution | 2˙499˙238 € (100%) |
Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
Code Call | ERC-2016-ADG |
Funding Scheme | ERC-ADG |
Starting year | 2017 |
Duration (year-month-day) | from 2017-07-01 to 2022-06-30 |
Take a look of project's partnership.
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1 | UNIVERSITY OF BRISTOL | UK (BRISTOL) | coordinator | 2˙499˙238.00 |
We propose to undertake an ambitious 5-year multidisciplinary programme that seeks to pioneer and establish a fundamentally new paradigm in protolife research that is based on novel conceptual and experimental advances in the design and construction of rudimentary forms of synthetic cell-like micro-ensembles (protocells). Our approach is positioned at the interface between materials chemistry, soft matter science and synthetic biology, and will address the following aspects of protocell design and construction: (i) functional complexity in protocell phenotypes, (ii) protocell self-structuring and metamorphosis, (iii) multi-compartmentalization and protocell endosymbiosis, and (iv) collective behavior in protocell communities. We will initiate unprecedented increases in the complexity of individual protocells by developing new types of structural architectures with advanced functions including photosynthetic protocells and motile proteinosomes, and develop innovative strategies for the chemical secretion of spatially extended extra-protocellular hydrogel matrices and induction of protocell metamorphosis. We will develop a modular micro-engineering approach to protocell multi-compartmentalization with the aim of generating coordinated enzyme- and gene-activated endosymbiotic interactions, and pioneer the experimental study of collective behaviour in communities of synthetic protocells. Our overall aim is to pioneer a modern approach to synthetic cellularity that advances the chemical and physical basis of protocell structure and function, and spearheads the development of future technologies based on autonomously functioning chemical micro-compartments with applications in bioinspired micro-storage and delivery, micro-reactor technologies, cytomimetic engineering, and the development of integrated constructs for diverse procedures in synthetic biology.
year | authors and title | journal | last update |
---|---|---|---|
2020 |
Pierangelo Gobbo, Liangfei Tian, B. V. V. S Pavan Kumar, Samuel Turvey, Mattia Cattelan, Avinash J. Patil, Mauro Carraro, Marcella Bonchio, Stephen Mann Catalytic processing in ruthenium-based polyoxometalate coacervate protocells published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-13759-1 |
Nature Communications 11/1 | 2020-03-13 |
2019 |
Nicolas Martin, Liangfei Tian, Dan Spencer, Angélique Coutable-Pennarun, J. L. Ross Anderson, Stephen Mann Photoswitchable Phase Separation and Oligonucleotide Trafficking in DNA Coacervate Microdroplets published pages: 14594-14598, ISSN: 1433-7851, DOI: 10.1002/anie.201909228 |
Angewandte Chemie International Edition 58/41 | 2020-03-13 |
2018 |
B. V. V. S. Pavan Kumar, Avinash J. Patil, Stephen Mann Enzyme-powered motility in buoyant organoclay/DNA protocells published pages: 1154-1163, ISSN: 1755-4330, DOI: 10.1038/s41557-018-0119-3 |
Nature Chemistry 10/11 | 2019-09-02 |
2018 |
Jean-Paul Douliez, Nicolas Martin, Thomas Beneyton, Jean-Charles Eloi, Jean-Paul Chapel, Laurence Navailles, Jean-Christophe Baret, Stephen Mann, Laure Béven Preparation of Swellable Hydrogel-Containing Colloidosomes from Aqueous Two-Phase Pickering Emulsion Droplets published pages: 7780-7784, ISSN: 1433-7851, DOI: 10.1002/anie.201802929 |
Angewandte Chemie International Edition 57/26 | 2019-09-02 |
2018 |
B. V. V. S. Pavan Kumar, James Fothergill, Joshua Bretherton, Liangfei Tian, Avinash J. Patil, Sean A. Davis, Stephen Mann Chloroplast-containing coacervate micro-droplets as a step towards photosynthetically active membrane-free protocells published pages: 3594-3597, ISSN: 1359-7345, DOI: 10.1039/c8cc01129j |
Chemical Communications 54/29 | 2019-09-02 |
2019 |
Alex Joesaar, Shuo Yang, Bas Bögels, Ardjan van der Linden, Pascal Pieters, B. V. V. S. Pavan Kumar, Neil Dalchau, Andrew Phillips, Stephen Mann, Tom F. A. de Greef DNA-based communication in populations of synthetic protocells published pages: 369-378, ISSN: 1748-3387, DOI: 10.1038/s41565-019-0399-9 |
Nature Nanotechnology 14/4 | 2019-09-02 |
2018 |
Nicolas Martin, Jean-Paul Douliez, Yan Qiao, Richard Booth, Mei Li, Stephen Mann Antagonistic chemical coupling in self-reconfigurable host–guest protocells published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06087-3 |
Nature Communications 9/1 | 2019-09-02 |
2019 |
Laura RodrÃguez-Arco, B. V. V. S. Pavan Kumar, Mei Li, Avinash J. Patil, Stephen Mann Modulation of Higher-order Behaviour in Model Protocell Communities by Artificial Phagocytosis published pages: 6333-6337, ISSN: 1433-7851, DOI: 10.1002/anie.201901469 |
Angewandte Chemie International Edition 58/19 | 2019-09-02 |
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