Opendata, web and dolomites

3DviralRNA

Structural and functional characterization of large viral and human non-coding RNA motifs involved in HIV infection

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 3DviralRNA project word cloud

Explore the words cloud of the 3DviralRNA project. It provides you a very rough idea of what is the project "3DviralRNA" about.

questions    enrich    worldwide    infection    2mi    employ    players    genomic    remodeling    impossibility    structures    vivo    strains    resistance    530    translation    nt    action    latent    host    potentially    complexity    frameshifting    cell    reveal    biology    viral    rates    genome    silencing    expression    450    viruses    3d    synthesis    complemented    packaging    interacts    prc2    virus    steadily    gag    coding    antiretroviral    deaths    epigenetic    splicing    rna    export    200    suggesting    regulate    genes    fundamental    tar    infections    interactions    partly    insights    structural    ways    proteins    pol    opening    400    enzymes    revealing    cellular    rre    11    biochemical    human    prc1    chromatin    larger    mechanisms    latency    domains    unknown    induce    functional    unprecedented    details    infectivity    expand    protein    structure    molecular    polycomb    eradicating    hotair    gene    rnas    vitro    motifs    correct    lt    gt    alter    domain    regulates    favoring    lncrnas    therapies    nuclear    conserved    hiv    progression    motif    pathogenesis    assays    unravel    encompasses   

Project "3DviralRNA" data sheet

The following table provides information about the project.

Coordinator
EUROPEAN MOLECULAR BIOLOGY LABORATORY 

Organization address
address: Meyerhofstrasse 1
city: HEIDELBERG
postcode: 69117
website: http://www.embl.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) coordinator 159˙460.00

Map

 Project objective

HIV infections cause 1.2Mi deaths/year worldwide at steadily-increasing rates, partly because of antiretroviral resistance and the impossibility of eradicating latent viruses. To expand our understanding of HIV pathogenesis, we need to unravel all molecular mechanisms involved in HIV progression. Large viral and human RNAs are emerging as key players in HIV infection. To characterize such RNAs, I will employ an integrated structural biology approach complemented by biochemical and functional assays in vitro and in vivo and I will address two fundamental questions: 1. How does the structure of HIV genomic RNA regulate HIV infectivity? HIV genomic RNA regulates nuclear export, packaging, splicing, and translation of viral proteins. 3D structures are known for short motifs (<200 nt), e.g. TAR and RRE. Such motifs are part of 11 larger domains (>400 nt), whose structures are unknown but conserved across HIV strains suggesting functional importance. We will study domain 2 (450 nt), which encompasses the gag-pol frameshifting motif and is crucial for correct protein synthesis. Our work will offer unprecedented insights into the structural complexity of the genome of an RNA virus. 2. How does the structure of human long non-coding RNAs (lncRNAs) affect the host-cell response to HIV infection? HIV infections alter expression of human lncRNAs, e.g. HOTAIR, which regulate Polycomb chromatin remodeling enzymes, e.g. PRC1/PRC2, favoring epigenetic silencing and latency of HIV genes. Interactions between HOTAIR and PRC1/PRC2 are not well characterized at the molecular level. We will study HOTAIR domain 1 (530 nt), which interacts with PRC1/PRC2 and regulates their cellular action. Such work will reveal novel mechanisms of epigenetic gene-silencing that induce HIV latency. By revealing molecular details of HIV and human RNAs, our study will enrich our understanding of HIV infectivity, potentially opening new ways for future therapies against RNA viruses.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "3DVIRALRNA" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "3DVIRALRNA" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

TheaTheor (2018)

Theorizing the Production of 'Comedia Nueva': The Process of Play Configuration in Spanish Golden Age Theater

Read More  

GENI (2019)

Gender, emotions and national identities: a new perspective on the abortion debates in Italy (1971-1981).

Read More  

ICL CHROM (2020)

DNA interstrand crosslink repair and chromatin remodelling

Read More  
lastchecktime (2025-04-03 3:33:52) correctly updated