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NeMatrix

Nematode-based screening technology for next-generation drug discovery

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 NeMatrix project word cloud

Explore the words cloud of the NeMatrix project. It provides you a very rough idea of what is the project "NeMatrix" about.

nematrix    rate    throughput    refinement    food    industries    desired    nematodes    worm    industrial    context    concentration    population    automated    microcompartments    reproducibility    device    elegans    operations    mammals    pharmaceutical    technological    close    separate    standards    expose    microfluidic    protocols    models    species    culture    size    rely    caenorhabditis    data    phenotypes    startup    drug    lacking    popular    observation    proving    tests    microscopic    biomedical    definitely    examples    gap    fill    company    multiple    monitor    manual    employ    suspension    technologies    platform    suitable    model    roundworm    interesting    envisioned    creation    concentrations    framework    time    distribute    named    handling    flies    starting    big    completely    gently    first    alternative    hinders    organisms    worms    feed    discovery    roundworms    generation    store    techniques    prototype    actual    screening    organism    replacement    animal    maintenance    paving    clinical    replacing    proposes   

Project "NeMatrix" data sheet

The following table provides information about the project.

Coordinator
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2018-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 150˙000.00

Map

 Project objective

Alternative model organisms, such as worms or flies, are getting increasingly popular in the drug discovery field, since they are proving to be suitable for replacing mammals for several aspects of the screening tests in the pre-clinical phase. In this context, one of the most interesting models is a roundworm species, named Caenorhabditis elegans. Its microscopic size, however, hinders its actual use in the field, since the protocols for its maintenance and study still completely rely on manual handling/observation techniques, definitely lacking any reproducibility and throughput standards. The NeMatrix project proposes to fill this technological gap, by developing a microfluidic platform for fully automated culture and analysis of C. elegans –and, more in general, roundworms-, tailored for drug screening applications. Specifically, starting from a simple worm suspension, our envisioned prototype will employ a set of microfluidic-based automated operations to: (i) gently distribute nematodes within separate microcompartments; (ii) feed them at desired food rate, time and concentration; (iii) expose them to drug tests at desired rate, time and drug concentrations; (iv) continuously monitor multiple phenotypes over the whole worm population in the device; (v) provide real-time data analysis and store/exploit results in a “big data” approach. This project would provide one of the first examples of next-generation technologies for whole-organism drug screening, with the potential of paving the way for the widespread use of worms and other alternative model organisms for the replacement, reduction and refinement of animal testing in biomedical research and pharmaceutical industries. The project will be held in close collaboration with key industrial partners in the field, in the framework of a planned startup company, which currently is on the way of creation.

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The information about "NEMATRIX" are provided by the European Opendata Portal: CORDIS opendata.

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