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NeMatrix

Nematode-based screening technology for next-generation drug discovery

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 NeMatrix project word cloud

Explore the words cloud of the NeMatrix project. It provides you a very rough idea of what is the project "NeMatrix" about.

nematrix    elegans    definitely    proposes    throughput    creation    technological    store    reproducibility    organisms    separate    manual    generation    completely    size    roundworms    platform    pharmaceutical    paving    expose    startup    handling    biomedical    prototype    replacing    screening    standards    replacement    observation    maintenance    microscopic    distribute    animal    model    named    concentration    time    caenorhabditis    culture    worms    hinders    roundworm    technologies    lacking    microfluidic    close    fill    nematodes    gap    microcompartments    popular    drug    techniques    envisioned    rate    organism    proving    data    device    mammals    clinical    examples    discovery    framework    monitor    population    refinement    suitable    automated    industrial    worm    context    big    concentrations    industries    company    flies    first    multiple    suspension    gently    operations    tests    species    models    rely    food    protocols    interesting    desired    starting    alternative    phenotypes    feed    employ    actual   

Project "NeMatrix" data sheet

The following table provides information about the project.

Coordinator
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2018-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 150˙000.00

Map

 Project objective

Alternative model organisms, such as worms or flies, are getting increasingly popular in the drug discovery field, since they are proving to be suitable for replacing mammals for several aspects of the screening tests in the pre-clinical phase. In this context, one of the most interesting models is a roundworm species, named Caenorhabditis elegans. Its microscopic size, however, hinders its actual use in the field, since the protocols for its maintenance and study still completely rely on manual handling/observation techniques, definitely lacking any reproducibility and throughput standards. The NeMatrix project proposes to fill this technological gap, by developing a microfluidic platform for fully automated culture and analysis of C. elegans –and, more in general, roundworms-, tailored for drug screening applications. Specifically, starting from a simple worm suspension, our envisioned prototype will employ a set of microfluidic-based automated operations to: (i) gently distribute nematodes within separate microcompartments; (ii) feed them at desired food rate, time and concentration; (iii) expose them to drug tests at desired rate, time and drug concentrations; (iv) continuously monitor multiple phenotypes over the whole worm population in the device; (v) provide real-time data analysis and store/exploit results in a “big data” approach. This project would provide one of the first examples of next-generation technologies for whole-organism drug screening, with the potential of paving the way for the widespread use of worms and other alternative model organisms for the replacement, reduction and refinement of animal testing in biomedical research and pharmaceutical industries. The project will be held in close collaboration with key industrial partners in the field, in the framework of a planned startup company, which currently is on the way of creation.

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The information about "NEMATRIX" are provided by the European Opendata Portal: CORDIS opendata.

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