BLASTOFF SIGNED
Retooling plant immunity for resistance to blast fungi
Total Cost €
0EC-Contrib. €
0Partnership
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Explore the words cloud of the BLASTOFF project. It provides you a very rough idea of what is the project "BLASTOFF" about.
Project "BLASTOFF" data sheet
The following table provides information about the project.
| Coordinator |
THE SAINSBURY LABORATORY
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Total cost | 2˙491˙893 € |
| EC max contribution | 2˙491˙893 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2016-ADG |
| Funding Scheme | ERC-ADG |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-09-01 to 2022-08-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | THE SAINSBURY LABORATORY | UK (NORWICH) | coordinator | 1˙874˙187.00 |
| 2 | JOHN INNES CENTRE | UK (NORWICH) | participant | 617˙706.00 |
Map
Project objective
Plant NLR-type immune receptors tend to have a narrow spectrum of pathogen recognition, which is currently limiting their value in agriculture. NLRs can recognize pathogen effectors through unconventional domains that have evolved by duplication of an effector target followed by fusion into the NLR. One NLR with an integrated domain is the rice resistance protein Pik-1, which binds an effector of the blast fungus Magnaporthe oryzae via its Heavy-Metal Associated (HMA) domain. We solved the crystal structure of the HMA domain of Pik-1 in complex with a blast fungus effector and gained an unprecedented level of detail of the molecular interactions that define pathogen recognition. This led to the overall aim of this proposal to generate a complete picture of the biophysical interactions between blast fungus effectors and HMA-containing cereal proteins to guide the retooling of the plant immune system towards resistance to blast diseases. M. oryzae is a general cereal killer that infects wheat, barley and rice, which are staple food for a majority of the world population. The central hypothesis of the proposed research is that mutations in cereal HMA-containing proteins will result in broad-spectrum resistance to blast fungi.
To achieve our goal, we will pursue the following objectives:
1. BIOPHYSICS. Define the biophysical properties that underpin binding of M. oryzae effectors to HMA-containing proteins of cereal crops.
2. RECEPTOR ENGINEERING. Develop Pik-1 receptors that respond to a wide-spectrum of M. oryzae effectors.
3. GENOME EDITING. Mutate HMA domain-containing genes in cereal genomes to confer broad-spectrum blast resistance.
At the completion of this project, we will generate a thorough understanding of the biophysical properties of pathogen effector binding to cereal HMA proteins, and deliver traits and non-transgenic cultivars for breeding blast disease resistance in cereal crops.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
Adam R Bentham, Rafał Zdrzałek, Juan Carlos De la Concepcion, Mark J Banfield Uncoiling CNLs: Structure/function approaches to understanding CC domain function in plant NLRs published pages: , ISSN: 0032-0781, DOI: 10.1093/pcp/pcy185 |
Plant and Cell Physiology | 2019-05-23 |
| 2018 |
Aleksandra Białas, Erin K. Zess, Juan Carlos De la Concepcion, Marina Franceschetti, Helen G. Pennington, Kentaro Yoshida, Jessica L. Upson, Emilie Chanclud, Chih-Hang Wu, Thorsten Langner, Abbas Maqbool, Freya A. Varden, Lida Derevnina, Khaoula Belhaj, Koki Fujisaki, Hiromasa Saitoh, Ryohei Terauchi, Mark J. Banfield, Sophien Kamoun Lessons in Effector and NLR Biology of Plant-Microbe Systems published pages: 34-45, ISSN: 0894-0282, DOI: 10.1094/mpmi-08-17-0196-fi |
Molecular Plant-Microbe Interactions 31/1 | 2019-05-27 |
| 2018 |
Jessica L Upson, Erin K Zess, Aleksandra Białas, Chih-hang Wu, Sophien Kamoun The coming of age of EvoMPMI: evolutionary molecular plant–microbe interactions across multiple timescales published pages: 108-116, ISSN: 1369-5266, DOI: 10.1016/j.pbi.2018.03.003 |
Current Opinion in Plant Biology 44 | 2019-05-23 |
| 2019 |
Apinya Longya, Chaivarakun Chaipanya, Marina Franceschetti, Josephine H.R. Maidment, Mark James Banfield, Chatchawan Jantasuriyarat Gene duplication and mutation in the emergence of a novel aggressive allele of the AVR-Pik effector in the rice blast fungus published pages: , ISSN: 0894-0282, DOI: 10.1094/mpmi-09-18-0245-r |
Molecular Plant-Microbe Interactions | 2019-05-23 |
| 2018 |
Thorsten Langner, Sophien Kamoun, Khaoula Belhaj CRISPR Crops: Plant Genome Editing Toward Disease Resistance published pages: 479-512, ISSN: 0066-4286, DOI: 10.1146/annurev-phyto-080417-050158 |
Annual Review of Phytopathology 56/1 | 2019-05-27 |
| 2019 |
Dipali Rani Gupta, Claudia Sarai Reyes Avila, Joe Win, Darren M. Soanes, Lauren S. Ryder, Daniel Croll, Pallab Bhattacharjee, Md. Shaid Hossain, Nur Uddin Mahmud, Md. Shabab Mehebub, Musrat Zahan Surovy, Md. Mahbubur Rahman, Nicholas J. Talbot, Sophien Kamoun, M. Tofazzal Islam Cautionary Notes on Use of the MoT3 Diagnostic Assay for Magnaporthe oryzae Wheat and Rice Blast Isolates published pages: 504-508, ISSN: 0031-949X, DOI: 10.1094/phyto-06-18-0199-le |
Phytopathology 109/4 | 2019-05-23 |
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