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RHEA SIGNED

Rotifers Highlight the Evolution of Asexuals: the mechanisms of genome evolution in the absence of meiosis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 RHEA project word cloud

Explore the words cloud of the RHEA project. It provides you a very rough idea of what is the project "RHEA" about.

resistance    spo11    arose    dna    adineta    components    revolutionize    notorious    desiccation    suggest    highest    genomics    predominant    uncover    plan    function    asexuals    meiotic    asexuality    genome    meiosis    gain    complementation    clades    gene    diversification    theoretical    interesting    assays    evolution    strand    bdelloid    deterioration    taxa    rank    asexual    overwhelmingly    cellular    rotifer    breaks    positive    unclear    bdelloids    generate    population    diverged    group    experiments    never    despite    vaga    fundamental    mutagenesis    taxonomic    molecular    rad    rotifers    ancient    first    persist    sex    sister    reproduce    repair    perform    ameiotic    lineages    predictions    why    double    species    computational    reproduction    appear    genetic    absence    published    negative    asexually    metazoans    lifestyle    sequence    sequencing    prolonged    insights    biological    sexual    erc    prevent    simulation    time    recombination    genomic    confirming    genomes    adaptive    model    contact    mechanisms    ago   

Project "RHEA" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE NAMUR ASBL 

Organization address
address: RUE DE BRUXELLES 61
city: NAMUR
postcode: 5000
website: www.unamur.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 1˙908˙375 €
 EC max contribution 1˙908˙375 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE NAMUR ASBL BE (NAMUR) coordinator 1˙908˙375.00

Map

 Project objective

Why sexual reproduction is overwhelmingly predominant among the metazoans remains unclear. Ancient asexual taxa are interesting model systems to gain general insights into the adaptive values of sex. The most notorious and the highest taxonomic rank within the metazoans to reproduce asexually is the bdelloid rotifers. While studies suggest that most asexuals arose recently, the published genome of the bdelloid rotifer Adineta vaga provided the first positive evidence for the long-term ameiotic evolution of this group, confirming its ancient asexuality. How bdelloid rotifers have been able to persist despite the expected negative consequences of asexuality is the focus of this ERC proposal. I will study the mechanisms that prevent genome deterioration and promote diversification in the absence of meiotic recombination. I will include sexual rotifer sister clades in the comparison and study all components of the bdelloid lifestyle that may foster their evolution. One of the key components could be their desiccation resistance and the associated DNA double-strand breaks that appear upon prolonged desiccation. To this end, I plan to (i) sequence genomes of sexual rotifers and distinct bdelloid species that diverged a long time ago, including lineages that never experience desiccation; (ii) apply contact genomics, cellular and molecular assays, as well as targeted mutagenesis to uncover their DNA repair mechanisms; (iii) use whole-genome and RAD sequencing to perform a population genomic study of genetic exchanges among bdelloids; and (iv) investigate the function of the meiosis-specific Spo11 gene in bdelloids through targeted mutagenesis and complementation experiments. Using a computational simulation I will generate theoretical predictions on the impact of the mechanisms promoting genome evolution in asexuals. This proposal should revolutionize the field of asexual evolution and provide a new biological model system to study fundamental processes such as DNA repair.

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The information about "RHEA" are provided by the European Opendata Portal: CORDIS opendata.

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