Explore the words cloud of the Evoland project. It provides you a very rough idea of what is the project "Evoland" about.
The following table provides information about the project.
Coordinator |
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Organization address contact info |
Coordinator Country | Spain [ES] |
Total cost | 2˙499˙513 € |
EC max contribution | 2˙499˙513 € (100%) |
Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
Code Call | ERC-2016-ADG |
Funding Scheme | ERC-ADG |
Starting year | 2017 |
Duration (year-month-day) | from 2017-09-01 to 2022-08-31 |
Take a look of project's partnership.
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1 | AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS | ES (MADRID) | coordinator | 2˙499˙513.00 |
Evolution of animal morphology relies on changes in developmental programs that control body plans and organ shape. Such changes are thought to arise form alteration of the expression of functionally conserved developmental genes and their vast downstream networks. Although this hypothesis has a profound impact on the way we view animal evolution, final proof is still lacking. The hypothesis calls for evolution to take place mainly through modifications of cis-regulatory elements (CREs) controlling gene expression. However, these genomic regions are precisely those that we understand the least and, until recently, basic knowledge on how regulatory information is organized in the 3D genome or how to spatio-temporally assign CREs to their target genes was unknown. The advent of next generation sequencing-based tools has made possible to identify genome-wide CREs and reveal how they are organized in the 3D genome. But this new knowledge has been largely ignored by most hypotheses on the evolution of gene expression, development and animal morphology. These new high-throughput methods have been mainly restricted to selected model organisms, and due to the lack of sequence conservation of CREs across lineages, we still have very limited information about the impact of CREs on animal morphology evolution. By integrating in a systematic and phylogenetically driven manner the contribution of CREs and their 3D organization to animal morphology at different evolutionary scales, we will for the first time link evolution, regulatory information, genome 3D architecture and morphology. We will apply this strategy to study animal morphology along the evolution of deuterostome body plans, the generation of fin morphological diversity in vertebrates, and the recent phenotypic changes in fish adapted to cave environments. Our proposal will make ground-breaking advances in our understanding of the global principles underlying the evolution of cis-regulatory DNA and animal form.
year | authors and title | journal | last update |
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2019 |
José M. Santos-Pereira, Lourdes Gallardo-Fuentes, Ana Neto, Rafael D. Acemel, Juan J. Tena Pioneer and repressive functions of p63 during zebrafish embryonic ectoderm specification published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-11121-z |
Nature Communications 10/1 | 2020-04-01 |
2020 |
Marta Silvia Magri, Sandra Jiménez-Gancedo, Stephanie Bertrand, Alicia Madgwick, Hector Escrivà , Patrick Lemaire, José Luis Gómez-Skarmeta Assaying Chromatin Accessibility Using ATAC-Seq in Invertebrate Chordate Embryos published pages: , ISSN: 2296-634X, DOI: 10.3389/fcell.2019.00372 |
Frontiers in Cell and Developmental Biology 7 | 2020-03-05 |
2019 |
Daniel Aldea, Lucie Subirana, Celine Keime, Lydvina Meister, Ignacio Maeso, Sylvain Marcellini, Jose Luis Gomez-Skarmeta, Stephanie Bertrand, Hector Escriva Genetic regulation of amphioxus somitogenesis informs the evolution of the vertebrate head mesoderm published pages: 1233-1240, ISSN: 2397-334X, DOI: 10.1038/s41559-019-0933-z |
Nature Ecology & Evolution 3/8 | 2020-03-05 |
2018 |
JoaquÃn Letelier, Elisa de la Calle-Mustienes, Joyce Pieretti, Silvia Naranjo, Ignacio Maeso, Tetsuya Nakamura, Juan Pascual-Anaya, Neil H. Shubin, Igor Schneider, Juan Ramón Martinez-Morales, José Luis Gómez-Skarmeta A conserved Shh cis-regulatory module highlights a common developmental origin of unpaired and paired fins published pages: 504-509, ISSN: 1061-4036, DOI: 10.1038/s41588-018-0080-5 |
Nature Genetics 50/4 | 2019-10-08 |
2019 |
Alicia Madgwick, Marta Silvia Magri, Christelle Dantec, Damien Gailly, Ulla-Maj Fiuza, Léo Guignard, Sabrina Hettinger, Jose Luis Gomez-Skarmeta, Patrick Lemaire Evolution of embryonic cis-regulatory landscapes between divergent Phallusia and Ciona ascidians published pages: , ISSN: 0012-1606, DOI: 10.1016/j.ydbio.2019.01.003 |
Developmental Biology | 2019-10-08 |
2018 |
Martin Franke, José Luis Gómez-Skarmeta An evolutionary perspective of regulatory landscape dynamics in development and disease published pages: 24-29, ISSN: 0955-0674, DOI: 10.1016/j.ceb.2018.06.009 |
Current Opinion in Cell Biology 55 | 2019-10-08 |
2018 |
Ibai Irastorza-Azcarate, Rafael D. Acemel, Juan J. Tena, Ignacio Maeso, José Luis Gómez-Skarmeta, Damien P. Devos 4Cin: A computational pipeline for 3D genome modeling and virtual Hi-C analyses from 4C data published pages: e1006030, ISSN: 1553-7358, DOI: 10.1371/journal.pcbi.1006030 |
PLOS Computational Biology 14/3 | 2019-10-08 |
2018 |
JoaquÃn Letelier, Javier Terriente, Ivan Belzunce, Adria Voltes, Cristian Alberto Undurraga, Rocio Polvillo, Lucie Devos, Juan J. Tena, Ignacio Maeso, Sylvie Retaux, José Luis Gomez-Skarmeta, Juan R. MartÃnez-Morales, Cristina Pujades Evolutionary emergence of the rac3b / rfng / sgca regulatory cluster refined mechanisms for hindbrain boundaries formation published pages: E3731-E3740, ISSN: 0027-8424, DOI: 10.1073/pnas.1719885115 |
Proceedings of the National Academy of Sciences 115/16 | 2019-10-08 |
2018 |
Ferdinand Marlétaz, Panos N. Firbas, Ignacio Maeso, Juan J. Tena, Ozren Bogdanovic, Malcolm Perry, Christopher D. R. Wyatt, Elisa de la Calle-Mustienes, Stephanie Bertrand, Demian Burguera, Rafael D. Acemel, Simon J. van Heeringen, Silvia Naranjo, Carlos Herrera-Ubeda, Ksenia Skvortsova, Sandra Jimenez-Gancedo, Daniel Aldea, Yamile Marquez, Lorena Buono, Iryna Kozmikova, Jon Permanyer, Alexandra Amphioxus functional genomics and the origins of vertebrate gene regulation published pages: 64-70, ISSN: 0028-0836, DOI: 10.1038/s41586-018-0734-6 |
Nature 564/7734 | 2019-10-08 |
2018 |
José Luis Ruiz, Juan J Tena, Cristina Bancells, Alfred Cortés, José Luis Gómez-Skarmeta, Elena Gómez-DÃaz Characterization of the accessible genome in the human malaria parasite Plasmodium falciparum published pages: 9414-9431, ISSN: 0305-1048, DOI: 10.1093/nar/gky643 |
Nucleic Acids Research 46/18 | 2019-10-08 |
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