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Opendata, web and dolomites

AMPHORA SIGNED

ACOUSTIC MARKERS FOR ENHANCED REMOTE SENSING OF RADIATION DOSES

Total Cost €

EC-Contrib. €

Partnership

Views

Outcomes and
results

AMPHORA project word cloud

Explore the words cloud of the AMPHORA project. It provides you a very rough idea of what is the project "AMPHORA" about.

read protocols safety revolutionize distributed radiotherapy enabled ucas patient efficacy validation approximately 50 data sensitive patients completion irradiation trigger implies 2d receive quantify tumor dose tissue avalanche hereby maximise radiation invasive healthy cancer acoustic signal quality modulation agents technologies gather minimize compare situ pave vivo ultrasound successful imaging follow translate 3d uca dosage assurance unmistakably map extract line interrogation clinical treatment injectable casting aforementioned imparted full algorithms sensing modalities contrast upgraded strategies backscatter inhibiting customised therapy theranostic appropriate signature dosimetry actual amfora

Project "AMPHORA" data sheet

The following table provides information about the project.

Coordinator	KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: OUDE MARKT 13 city: LEUVEN postcode: 3000 website: www.kuleuven.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Belgium [BE]
Project website	http://www.amphora-project.eu
Total cost	3˙932˙775 €
EC max contribution	3˙932˙775 € (100%)
Programme	1. H2020-EU.1.2.1. (FET Open)
Code Call	H2020-FETOPEN-1-2016-2017
Funding Scheme	RIA
Starting year	2017
Duration (year-month-day)	from 2017-11-01 to 2021-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KATHOLIEKE UNIVERSITEIT LEUVEN KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: OUDE MARKT 13 city: LEUVEN postcode: 3000 website: www.kuleuven.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LEUVEN)	coordinator	1˙563˙750.00
2	FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. Organization address address: HANSASTRASSE 27C city: MUNCHEN postcode: 80686 website: www.fraunhofer.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUNCHEN)	participant	679˙878.00
3	UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA Organization address address: VIA CRACOVIA 50 city: ROMA postcode: 133 website: www.uniroma2.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	participant	475˙000.00
4	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Organization address address: DR MOLEWATERPLEIN 40 city: ROTTERDAM postcode: 3015 GD website: www.erasmusmc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ROTTERDAM)	participant	443˙750.00
5	INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM Organization address address: KAPELDREEF 75 city: LEUVEN postcode: 3001 website: www.imec.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LEUVEN)	participant	393˙521.00
6	DOSEVUE DOSEVUE Organization address address: Agoralaan Abis city: Diepenbeek postcode: 3590 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (Diepenbeek)	participant	376˙875.00

Map

Project objective

Approximately 50% of all cancer patients receive radiation therapy as part of their treatment. The aim is hereby to maximise tumor irradiation and to minimize healthy tissue irradiation. This implies a need for appropriate dosimetry strategies that can effectively measure the actual radiation dose imparted on the tumor. However, state-of-the-art dosimetry cannot quantify the dose distribution in (and around) the tumor, hereby inhibiting the full potential of radiotherapy. AMFORA aims to develop a non-invasive in-situ dosimetry system for radiation therapy with the potential of on-line dose assessment by casting ultrasound contrast agents (UCAs) into dose sensing theranostic devices. UCAs will be upgraded to injectable dose-sensitive and targeted devices that gather in tumor tissue and translate imparted radiation dosage into a modulation of their acoustic response upon ultrasound interrogation. Tailored ultrasound imaging and advanced signal processing algorithms will be developed to extract the (change in) acoustic signature of UCAs from backscatter data and to translate this information into a 2D or 3D dose distribution map. The specific objectives of this project are the design, development and pre-clinical validation of the aforementioned UCA based dosimetry system and a customised ultrasound read-out technology. Upon successful completion, AMFORA will have enabled the assessment of the effective radiation dose distribution in (and around) the tumor, offering an advanced and objective means to compare and evaluate treatment efficacy of different radiotherapy modalities. Such novel technology would revolutionize quality assurance and treatment follow up in radiotherapy, which also unmistakably will lead to increased patient safety and improved treatment protocols. Moreover, AMFORA is expected to trigger an avalanche of novel technologies for radiation therapy delivery and to pave the way for other in-vivo UCA based distributed sensing applications.

Deliverables

List of deliverables.
Project Opening Event	Other	2019-05-31 10:19:33
review meeting documents meeting 1	Documents, reports	2019-05-31 10:19:27
Data Management Plan	Open Research Data Pilot	2019-05-31 10:19:34
Website & project logo	Websites, patent fillings, videos etc.	2019-05-31 10:19:32
Intermediate report on backscatter modeling	Documents, reports	2019-05-31 10:19:30
Dissemination and Exploitation Plan	Open Research Data Pilot	2019-05-31 10:19:32

Take a look to the deliverables list in detail: detailed list of AMPHORA deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Alexander Bertrand Utility Metrics for Assessment and Subset Selection of Input Variables for Linear Estimation [Tips & Tricks] published pages: 93-99, ISSN: 1053-5888, DOI: 10.1109/MSP.2018.2856632	IEEE Signal Processing Magazine 35/6	2019-05-28

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The information about "AMPHORA" are provided by the European Opendata Portal: CORDIS opendata.