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MADONNA SIGNED

Microbial deployment of new-to-nature chemistries for refactoring the barriers between living and non-living matter

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

MADONNA project word cloud

Explore the words cloud of the MADONNA project. It provides you a very rough idea of what is the project "MADONNA" about.

technologies performance planet suite agenda types function safety carrier dogma security settings flow engineered perceptions industry intermediate chassis herein prediction governance economic evolution assets reactions spin biology engineer fill instead stake successful once cyborg sustainable fold reverse chemo industrial synthetic recruitment chemical coupled madonna entirely compounds functioning utility environmental ramifications themselves liabilities public proteins waste biotransformations organo co2 nature directionality ized geochemical global of fitness tuning live elemental metabolism ethical si societal progressively ntn rna overcoming dna unprecedented rarr biosphere pursued code foundational silicon physico gaps capture bacterial central metabolites uni robots biologization biological molecular lifetime automated simulators

Project "MADONNA" data sheet

The following table provides information about the project.

Coordinator	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Project website	http://www.madonnaproject.eu
Total cost	2˙968˙817 €
EC max contribution	2˙968˙817 € (100%)
Programme	1. H2020-EU.1.2.1. (FET Open)
Code Call	H2020-FETOPEN-1-2016-2017
Funding Scheme	RIA
Starting year	2018
Duration (year-month-day)	from 2018-01-01 to 2021-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	coordinator	526˙713.00
2	EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Organization address address: Raemistrasse 101 city: ZUERICH postcode: 8092 website: https://www.ethz.ch/de.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ZUERICH)	participant	439˙327.00
3	UNIVERSITAT BASEL UNIVERSITAT BASEL Organization address address: PETERSPLATZ 1 city: BASEL postcode: 4051 website: www.unibas.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BASEL)	participant	429˙413.00
4	UNIVERSITY OF GLASGOW UNIVERSITY OF GLASGOW Organization address address: UNIVERSITY AVENUE city: GLASGOW postcode: G12 8QQ website: www.gla.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (GLASGOW)	participant	421˙875.00
5	BIOFACTION KG BIOFACTION KG Organization address address: KUNDMANNGASSE 39/12 city: WIEN postcode: 1030 website: www.biofaction.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	410˙310.00
6	Isthmus Isthmus Organization address address: Rue Saint Amand 31 city: Paris postcode: 75015 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (Paris)	participant	327˙500.00
7	UNIVERSIDAD POMPEU FABRA UNIVERSIDAD POMPEU FABRA Organization address address: PLACA DE LA MERCE, 10-12 city: BARCELONA postcode: 8002 website: www.upf.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	313˙450.00
8	SORBONNE UNIVERSITE SORBONNE UNIVERSITE Organization address address: 21 RUE DE L'ECOLE DE MEDECINE city: PARIS postcode: 75006 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	100˙227.00
9	UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6 UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6 Organization address address: Place Jussieu 4 city: PARIS postcode: 75252 website: www.upmc.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	0.00

Map

Project objective

This Project is about bringing a suite of chemical reactions (and its related non-biological compounds and elements) to the biological fold (i.e. their 'biologization') by going beyond the Central Dogma of Molecular Biology (DNA→ RNA→ proteins→ metabolism) through both tuning and overcoming the uni-directionality of the information flow. To reverse-engineer reactions into a biological code, the utility function of the chemical process of interest will be progressively coupled to the fitness function of a live carrier (e.g. an engineered, synthetic or cyborg-ized bacterial chassis), the intermediate steps being supported by automated chemo-robots. The new-to-nature reactions (NTN) pursued within the MADONNA lifetime as case studies will include CO2 capture and recruitment of elemental silicon to become part of essential organo-Si metabolites. Along with the development of the new reactions, the research agenda of the Project will also include the [i] modelling and prediction on the impact of the new biotransformations on the overall functioning of the Biosphere once/if adopted at a large scale by the industrial sector and [ii] design of environmental simulators for evaluating the performance and evolution of the new biological reactions under given physico-chemical settings. With such approaches, MADONNA aims to fill many of the gaps between the 3 types of global-scale processing of chemical elements operating in our planet: Geochemical, Biological and Industrial. The scale of applications of the foundational technologies developed herein (which spin themselves much beyond CO2 and silicon) is unprecedented and a large number of societal ramifications including ethical, security, safety, economic, governance and public perceptions aspects at stake will be included. If successful, MADONNA will enable an entirely new type of sustainable industry in which many types of waste become assets instead of liabilities.

Deliverables

List of deliverables.
Data management plan	Open Research Data Pilot	2019-05-16 21:00:47
Morbidostat for heterotic computation of (bio)chemical problems	Demonstrators, pilots, prototypes	2019-05-16 21:00:47
An integrated computational frame for merging NTN reactions to extant metabolism	Other	2019-05-16 21:00:47
Setup of a Project website and Logo	Websites, patent fillings, videos etc.	2019-05-16 21:00:47

Take a look to the deliverables list in detail: detailed list of MADONNA deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Ã–zlem Akkaya, Pablo I. Nikel, Danilo PÃ©rez-Pantoja, VÃctor de Lorenzo Evolving metabolism of 2,4-dinitrotoluene triggers SOS-independent diversification of host cells published pages: 314-326, ISSN: 1462-2912, DOI: 10.1111/1462-2920.14459	Environmental Microbiology 21/1	2019-05-16
2019	TomÃ¡s Aparicio, VÃctor de Lorenzo, Esteban MartÃnez-GarcÃa Improved Thermotolerance of Genome-Reduced Pseudomonas putida EM42 Enables Effective Functioning of the P L / c I857 System published pages: 1800483, ISSN: 1860-6768, DOI: 10.1002/biot.201800483	Biotechnology Journal 14/1	2019-05-16
2018	Max ChavarrÃa, VÃctor de Lorenzo The imbroglio of the physiological Cra effector clarified at last published pages: 273-277, ISSN: 0950-382X, DOI: 10.1111/mmi.14080	Molecular Microbiology 109/3	2019-05-16
2018	Blai Vidiella, Josep SardanyÃ©s, Ricard SolÃ© Exploiting delayed transitions to sustain semiarid ecosystems after catastrophic shifts published pages: 20180083, ISSN: 1742-5689, DOI: 10.1098/rsif.2018.0083	Journal of The Royal Society Interface 15/143	2019-05-16
2018	Pavel DvoÅ™Ã¡k, VÃctor de Lorenzo Refactoring the upper sugar metabolism of Pseudomonas putida for co-utilization of cellobiose, xylose, and glucose published pages: 94-108, ISSN: 1096-7176, DOI: 10.1016/j.ymben.2018.05.019	Metabolic Engineering 48	2019-05-16
2018	Ricard V. SolÃ©, RaÃºl MontaÃ±ez, Salva Duran-Nebreda, Daniel Rodriguez-Amor, Blai Vidiella, Josep SardanyÃ©s Population dynamics of synthetic terraformation motifs published pages: 180121, ISSN: 2054-5703, DOI: 10.1098/rsos.180121	Royal Society Open Science 5/7	2019-05-16
2018	Gonzalo Durante-RodrÃguez, VÃctor de Lorenzo, Pablo I. Nikel A Post-translational Metabolic Switch Enables Complete Decoupling of Bacterial Growth from Biopolymer Production in Engineered Escherichia coli published pages: 2686-2697, ISSN: 2161-5063, DOI: 10.1021/acssynbio.8b00345	ACS Synthetic Biology 7/11	2019-05-16
2018	VÃctor de Lorenzo Evolutionary tinkering vs. rational engineering in the times of synthetic biology published pages: , ISSN: 2195-7819, DOI: 10.1186/s40504-018-0086-x	Life Sciences, Society and Policy 14/1	2019-05-16
2018	Ã–zlem Akkaya, Danilo R. PÃ©rez-Pantoja, BelÃ©n Calles, Pablo I. Nikel, VÃctor de Lorenzo The Metabolic Redox Regime of Pseudomonas putida Tunes Its Evolvability toward Novel Xenobiotic Substrates published pages: , ISSN: 2150-7511, DOI: 10.1128/mbio.01512-18	mBio 9/4	2019-05-16

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