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ENTRANCE SIGNED

Developing the iTOP kit: Empowering scientists with efficient intracellular delivery of biologicals in hard-to-manipulate cell types

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

ENTRANCE project word cloud

Explore the words cloud of the ENTRANCE project. It provides you a very rough idea of what is the project "ENTRANCE" about.

diseases direct entrance create significantly line ntrans marketing itop pipeline wo2015028969 experiences possibilities dna community 2020 stem proper instigate cell lines latter efficient difficult extremely ambition sme back sharing team entry active tool manipulate immortalized scientific biomolecules investments expand proteins rna bioactive validated forecasted leader biomedical earn immense journal drug sciences mammalian transfect combinations molecules models therapeutic move inside underpin human primary 2015 unmet patented scientifically unprecedented published genetic interactive biomedically developers types innovative revolution notoriously cells ruo efficiency market fte standard pace kit 16 technologies stimulate forum accelerated biologically generously buzz bv merits empowering

Project "ENTRANCE" data sheet

The following table provides information about the project.

Coordinator	NTRANS TECHNOLOGIES BV Organization address address: UPPSALALAAN 8 city: UTRECHT postcode: 3584 CT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	https://www.ntranstechnologies.com/entrance/
Total cost	1˙514˙200 €
EC max contribution	1˙514˙200 € (100%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-SMEINST-2-2016-2017
Funding Scheme	SME-2
Starting year	2017
Duration (year-month-day)	from 2017-09-01 to 2019-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	NTRANS TECHNOLOGIES BV NTRANS TECHNOLOGIES BV Organization address address: UPPSALALAAN 8 city: UTRECHT postcode: 3584 CT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	coordinator	1˙514˙200.00

Map

Project objective

NTrans Technologies BV has developed iTOP; a novel and extremely effective method to deliver highly relevant bioactive molecules (including DNA, RNA, active proteins, and their combinations) into mammalian cells. This includes the efficient delivery of such molecules inside the most biologically and biomedically relevant cell types (e.g. human primary and stem cells), which are notoriously difficult to manipulate. iTOP technology has been scientifically validated (published in the top scientific journal Cell in 2015) and patented (WO2015028969).

iTOP addresses the unmet need of researchers and drug developers to be able to transfect a range of biomolecules into biologically relevant cell models; in particular to study genetic diseases and to underpin results obtained with standard immortalized cell lines.

The ENTRANCE project includes the necessary steps towards market entry of the iTOP research-use-only (RUO) kit: The development of (i) an iTOP RUO kit and (ii) an iTOP on-line community as innovative marketing tool that will support proper use and stimulate efficient application of the technology. The ENTRANCE project will thus provide the scientific community access to the novel iTOP tool, facilitate direct access of iTOP kit users to the NTrans support team, and enable sharing of user experiences via an iTOP interactive forum.

ENTRANCE will instigate a revolution in biomedical sciences by empowering both researchers and drug developers to manipulate the most relevant cell types with unprecedented efficiency. This will allow the field to move forward at a significantly accelerated pace.

The iTOP RUO kit will generously earn back the investments within 4 years, and help to create a buzz around the merits and possibilities of the technology. The latter is of immense value to the SME forecasted to support 16 FTE by 2020, with the ambition to expand its product pipeline and become leader in technologies for delivery of therapeutic biomolecules into primary cells.

Deliverables

List of deliverables.
3.4b iTOP community platform completed	Websites, patent fillings, videos etc.	2020-03-24 11:33:03
1.5b First lot of sample kit produced	Demonstrators, pilots, prototypes	2020-02-27 15:22:05
1.3 Digital user manuals completed	Documents, reports	2020-02-27 15:21:52
3.5b Final version of the DMP	Documents, reports	2019-07-30 13:59:42
3.1b Report of the Mid-Term event	Documents, reports	2019-05-31 11:55:55
3.3a Dedicated web pages for ENTRANCE	Websites, patent fillings, videos etc.	2019-05-31 11:55:51
3.1a Report of the Kick-off Event	Documents, reports	2019-05-31 11:55:52
3.5a First version of DMP	Documents, reports	2019-05-31 11:56:04

Take a look to the deliverables list in detail: detailed list of ENTRANCE deliverables.

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The information about "ENTRANCE" are provided by the European Opendata Portal: CORDIS opendata.