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eTRANSAFE SIGNED

Enhacing TRANslational SAFEty Assessment through Integrative Knowledge Management

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

eTRANSAFE project word cloud

Explore the words cloud of the eTRANSAFE project. It provides you a very rough idea of what is the project "eTRANSAFE" about.

mining types framework uniquely sources solutions skilled post interoperability predictive preclinical unprecedented recognised silico visualisation predictivity broker leverage balance proprietary technologies biomarkers sharing biomedical academic send confidentiality capacity preparation placed regulatory guarantee holistic expandable perfect honest toxicity clinical compliant etox international integration etransafe format collection infrastructure 13 medium small safety hub flexible optimal intensive data brings drug underpinned publicly marketing discovery modules mobilize computational elixir six guidelines prediction sme integrating handling cdisc restricted agencies documentation perspective enterprises demands prestigious tools powerful standards

Project "eTRANSAFE" data sheet

The following table provides information about the project.

Coordinator	FUNDACIO INSTITUT MAR D INVESTIGACIONS MEDIQUES IMIM Organization address address: Doctor Aiguader 88 city: BARCELONA postcode: 8003 website: www.imim.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Project website	http://etransafe.eu/
Total cost	39˙490˙899 €
EC max contribution	20˙000˙000 € (51%)
Programme	1. H2020-EU.3.1.7. (Innovative Medicines Initiative 2 (IMI2))
Code Call	H2020-JTI-IMI2-2016-09-two-stage
Funding Scheme	IMI2-RIA
Starting year	2017
Duration (year-month-day)	from 2017-09-01 to 2022-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FUNDACIO INSTITUT MAR D INVESTIGACIONS MEDIQUES IMIM FUNDACIO INSTITUT MAR D INVESTIGACIONS MEDIQUES IMIM Organization address address: Doctor Aiguader 88 city: BARCELONA postcode: 8003 website: www.imim.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	coordinator	2˙667˙675.00
2	SYNAPSE RESEARCH MANAGEMENT PARTNERS SL SYNAPSE RESEARCH MANAGEMENT PARTNERS SL Organization address address: CALLE VELAZQUEZ 94 PLANTA 1 city: MADRID postcode: 28006 website: www.synapse-managers.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	2˙953˙375.00
3	LHASA LIMITED LHASA LIMITED Organization address address: GRANARY WHARF HOUSE, 2 CANAL WHARF city: LEEDS postcode: LS11 5PS website: www.lhasalimited.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LEEDS)	participant	2˙930˙750.00
4	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Organization address address: DR MOLEWATERPLEIN 40 city: ROTTERDAM postcode: 3015 GD website: www.erasmusmc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ROTTERDAM)	participant	2˙169˙750.00
5	EUROPEAN MOLECULAR BIOLOGY LABORATORY EUROPEAN MOLECULAR BIOLOGY LABORATORY Organization address address: Meyerhofstrasse 1 city: HEIDELBERG postcode: 69117 website: http://www.embl.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	participant	1˙972˙375.00
6	UNIVERSIDAD POMPEU FABRA UNIVERSIDAD POMPEU FABRA Organization address address: PLACA DE LA MERCE, 10-12 city: BARCELONA postcode: 8002 website: www.upf.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	1˙504˙500.00
7	UNIVERSITEIT LEIDEN UNIVERSITEIT LEIDEN Organization address address: RAPENBURG 70 city: LEIDEN postcode: 2311 EZ website: www.universiteitleiden.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	1˙382˙825.00
8	MOLECULAR NETWORKS GMBH COMPUTERCHEMIE MOLECULAR NETWORKS GMBH COMPUTERCHEMIE Organization address address: NEUMEYERSTR 28-34 city: NURNBERG postcode: 90411 website: http://www.molecular-networks.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (NURNBERG)	participant	954˙125.00
9	UNIVERSITAT WIEN UNIVERSITAT WIEN Organization address address: UNIVERSITATSRING 1 city: WIEN postcode: 1010 website: www.univie.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	878˙000.00
10	PDS COMPUTER SOFTWARE LIMITED PDS COMPUTER SOFTWARE LIMITED Organization address address: 9 KNIGHTON GRANGE ROAD city: LEICESTER postcode: LE2 2LF website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LEICESTER)	participant	553˙375.00
11	OPTIBRIUM LIMITED OPTIBRIUM LIMITED Organization address address: F5-6 BLENHEIM HOUSE CAMBRIDGE INNOVATION PARK DENN city: Cambridge postcode: CB25 9PB website: www.optibrium.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (Cambridge)	participant	531˙500.00
12	LIVERPOOL JOHN MOORES UNIVERSITY LIVERPOOL JOHN MOORES UNIVERSITY Organization address address: RODNEY STREET 2 EGERTON COURT city: LIVERPOOL postcode: L3 5UX website: www.ljmu.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LIVERPOOL)	participant	528˙875.00
13	CERTARA UK LIMITED CERTARA UK LIMITED Organization address address: ONE LONDON WALL 6TH FLOOR city: LONDON postcode: EC2Y 5EB website: www.certara.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	521˙875.00
14	FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. Organization address address: HANSASTRASSE 27C city: MUNCHEN postcode: 80686 website: www.fraunhofer.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUNCHEN)	participant	451˙000.00
15	ABBVIE INC ABBVIE INC Organization address address: NORTH WAUKEGAN ROAD 1 city: NORTH CHICAGO IL postcode: 60064 website: www.abbvie.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (NORTH CHICAGO IL)	participant	0.00
16	ASTRAZENECA AB ASTRAZENECA AB Organization address address: Vastra Maelarhamnen city: SODERTAELJE postcode: 151 85 website: www.astrazeneca.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (SODERTAELJE)	participant	0.00
17	BAYER AKTIENGESELLSCHAFT BAYER AKTIENGESELLSCHAFT Organization address address: KAISER-WILHEM-ALLEE 1 city: Leverkusen postcode: 51373 website: http://pharma.bayer.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Leverkusen)	participant	0.00
18	BOEHRINGER INGELHEIM INTERNATIONALGMBH BOEHRINGER INGELHEIM INTERNATIONALGMBH Organization address address: BINGER STRASSE city: INGELHEIM postcode: 55218 website: www.boehringerâ€ingelheim.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (INGELHEIM)	participant	0.00
19	CLARIVATE ANALYTICS (UK) LIMITED CLARIVATE ANALYTICS (UK) LIMITED Organization address address: FRIARS HOUSE, 160 BLACKFRIAS ROAD city: LONDON postcode: EC1N 8JS website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	0.00
20	EISAI CO LTD EISAI CO LTD Organization address address: KOISHIKAWA 6-10 CHOME 4 city: BUNKYO KU TOKYO postcode: 112 88 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	JP (BUNKYO KU TOKYO)	participant	0.00
21	F. HOFFMANN-LA ROCHE AG F. HOFFMANN-LA ROCHE AG Organization address address: GRENZACHERSTRASSE 124 city: BASEL postcode: 4070 website: www.roche.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BASEL)	participant	0.00
22	INSTITUT DE RECHERCHES INTERNATIONALES SERVIER INSTITUT DE RECHERCHES INTERNATIONALES SERVIER Organization address address: RUE CARNOT 50 city: SURESNES postcode: 92284 website: www.servier.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (SURESNES)	participant	0.00
23	IPSEN INNOVATION SAS IPSEN INNOVATION SAS Organization address address: AVENUE DU CANADA - ZONE INDUSTRIELLE DE COURTABOEUF 5 city: LES ULIS postcode: 91940 website: http://www.ipsen.com/fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (LES ULIS)	participant	0.00
24	JANSSEN PHARMACEUTICA NV JANSSEN PHARMACEUTICA NV Organization address address: TURNHOUTSEWEG 30 city: BEERSE postcode: 2340 website: www.janssenpharmaceutica.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BEERSE)	participant	0.00
25	MERCK KOMMANDITGESELLSCHAFT AUF AKTIEN MERCK KOMMANDITGESELLSCHAFT AUF AKTIEN Organization address address: FRANKFURTER STRASSE 250 city: DARMSTADT postcode: 64293 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DARMSTADT)	participant	0.00
26	NOVARTIS PHARMA AG NOVARTIS PHARMA AG Organization address address: LICHTSTRASSE 35 city: BASEL postcode: 4056 website: www.novartis.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BASEL)	participant	0.00
27	SANOFI-AVENTIS DEUTSCHLAND GMBH SANOFI-AVENTIS DEUTSCHLAND GMBH Organization address address: BRUNINGSTRASSE 50 city: FRANKFURT AM MAIN postcode: 65929 website: www.sanofi.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (FRANKFURT AM MAIN)	participant	0.00

Map

Project objective

Drug safety assessment is a knowledge-intensive process that demands advancement in data handling methods and tools for facilitating data sharing, mining, analysis and predictive modelling. This need is not restricted to any specific type of data and real advancement requires integrating information of different types and from different sources (e.g. publicly available biomedical knowledge, proprietary preclinical and clinical data, evidence from post-marketing studies) for addressing drug safety assessment from a holistic perspective.

The eTRANSAFE project will address these needs by developing a powerful data integration infrastructure (Knowledge Hub) and a collection of computational tools (exploitation modules) for making optimal use of these data. The proposed system will be a flexible and expandable framework, built on previous experience and applying state-of-the-art methods and technologies for providing the most advanced solutions for data sharing, interoperability and exploitation. An experienced honest broker will guarantee the confidentiality of any proprietary data. The project will develop in silico tools for data mining, visualisation, and prediction of potential toxicity, with specific attention to the assessment of the preclinical to clinical predictivity and the discovery of safety biomarkers. The CDISC-SEND format will be supported, facilitating the preparation of regulatory-compliant documentation. This infrastructure will be underpinned by development of open standards and guidelines recognised by regulatory agencies and international organisations.

The eTRANSAFE consortium brings together 13 organizations that mobilize an unprecedented capacity and resources, uniquely placed to leverage the experience of eTOX and other EU projects and initiatives. The project partners are six prestigious academic institutions, six highly skilled small-medium enterprises (SME) and one European infrastructure (ELIXIR), bringing in this way a perfect balance.

Deliverables

List of deliverables.
Computational read-across workflows- first version	Documents, reports	2020-04-14 16:17:18
Machine-learning models - first version	Documents, reports	2020-04-14 16:17:19
Advanced data mining module - first version	Documents, reports	2020-04-14 16:17:18
Predictive models repository - first version	Documents, reports	2020-04-14 16:17:18
Safety assessment tools - first version	Documents, reports	2020-04-14 16:17:18
Report on quantitative weight of evidence methods and software specifications - first version	Documents, reports	2020-04-14 16:17:19
Report on knowledge gathering by analysing preclinical data â€“ final version	Documents, reports	2020-04-14 16:17:18
Methodology, analysis of existing related initiatives, and tools for implementation	Documents, reports	2020-04-14 16:17:18
Data export and reporting module - first version	Documents, reports	2020-04-14 16:17:18
Report on release of integrated textual data, identifier and semantic integration services, integrated ontologies, and ontology management and access services to consortium	Documents, reports	2020-04-14 16:17:18
First version of knowledge gathering services	Documents, reports	2020-04-14 16:17:18
Visualisation module - first version	Documents, reports	2020-04-14 16:17:18
Report on consortium needs, available assets and documented knowledge hub (WP9) interfaces	Documents, reports	2020-04-14 16:17:18
Knowledge Hub and API specifications - first version	Documents, reports	2020-04-14 16:17:18
Report on SEND data sharing exercise â€“ first version	Documents, reports	2020-04-14 16:17:18
Initial Data and Knowledge Management Plan	Documents, reports	2020-04-14 16:17:18
Project communication plan and initial tool set	Documents, reports	2020-04-14 16:17:18
Report on user requirements and system specifications of database(s)	Documents, reports	2020-04-14 16:17:18
Deployment of a data infrastructure for consortium partner access	Documents, reports	2020-04-14 16:17:18
Report on the procedures for the data donation, extraction, curation and normalisation, ontology mapping, and access to pertinent datasets	Documents, reports	2020-04-14 16:17:18
Report on knowledge gathering by analysing preclinical data	Documents, reports	2020-04-14 16:17:18
Report on SEND data sharing exercise â€“ third version	Documents, reports	2020-04-09 20:50:54
Report on data gathering, processing and database â€“ second version	Documents, reports	2020-04-09 20:50:45

Take a look to the deliverables list in detail: detailed list of eTRANSAFE deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Gopal Pawar, Judith C. Madden, David Ebbrell, James W. Firman, Mark T. D. Cronin In Silico Toxicology Data Resources to Support Read-Across and (Q)SAR published pages: , ISSN: 1663-9812, DOI: 10.3389/fphar.2019.00561	Frontiers in Pharmacology 10	2020-04-14
2018	Thomas Steger-Hartmann, Francois Pognan Improving the Safety Assessment of Chemicals and Drug Candidates by the Integration of Bioinformatics and Chemoinformatics Data published pages: 29-36, ISSN: 1742-7835, DOI: 10.1111/bcpt.12956	Basic & Clinical Pharmacology & Toxicology 123	2020-04-14
2018	Janet PiÃ±ero, Laura I Furlong, Ferran Sanz In silico models in drug development: where we are published pages: 111-121, ISSN: 1471-4892, DOI: 10.1016/j.coph.2018.08.007	Current Opinion in Pharmacology 42	2020-04-14
2019	Mark D. Pinches, Robert Thomas, Rosemary Porter, Lucinda Camidge, Katharine Briggs Curation and analysis of clinical pathology parameters and histopathologic findings from eTOXsys, a large database project (eTOX) for toxicologic studies published pages: 104396, ISSN: 0273-2300, DOI: 10.1016/j.yrtph.2019.05.021	Regulatory Toxicology and Pharmacology 107	2020-04-14
2017	Ferran Sanz, FranÃ§ois Pognan, Thomas Steger-Hartmann, Carlos DÃaz, Montserrat Cases, Manuel Pastor, Philippe Marc, Joerg Wichard, Katharine Briggs, David K. Watson, Thomas KleinÃ¶der, Chihae Yang, Alexander Amberg, Maria Beaumont, Anthony J. Brookes, SÃ¸ren Brunak, Mark T. D. Cronin, Gerhard F. Ecker, Sylvia Escher, Nigel Greene, Antonio GuzmÃ¡n, Anne Hersey, Pascale Jacques, Lieve Lammens, Jordi Mestres, Wolfgang Muster, Helle Northeved, Marc Pinches, Javier Saiz, Nicolas Sajot, Alfonso Valencia, Johan van der Lei, Nico P. E. Vermeulen, Esther Vock, Gerhard Wolber, Ismael Zamora Legacy data sharing to improve drug safety assessment: the eTOX project published pages: 811-812, ISSN: 1474-1776, DOI: 10.1038/nrd.2017.177	Nature Reviews Drug Discovery 16/12	2020-04-14
2018	Janet PiÃ±ero, Abel Gonzalez-Perez, Emre Guney, Joaquim Aguirre-Plans, Ferran Sanz, Baldo Oliva, Laura I. Furlong Network, Transcriptomic and Genomic Features Differentiate Genes Relevant for Drug Response published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2018.00412	Frontiers in Genetics 9	2020-04-14
2018	Manuel Pastor, Jordi Quintana, Ferran Sanz Development of an Infrastructure for the Prediction of Biological Endpoints in Industrial Environments. Lessons Learned at the eTOX Project published pages: , ISSN: 1663-9812, DOI: 10.3389/fphar.2018.01147	Frontiers in Pharmacology 9	2020-04-14
2017	Oriol LÃ³pez-Massaguer, Kevin Pinto-Gil, Ferran Sanz, Alexander Amberg, Lennart T Anger, Manuela Stolte, Carlo Ravagli, Philippe Marc, Manuel Pastor Generating Modeling Data From Repeat-Dose Toxicity Reports published pages: 287-300, ISSN: 1096-6080, DOI: 10.1093/toxsci/kfx254	Toxicological Sciences 162/1	2020-04-14

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