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IMBIBE SIGNED

Innovative technology solutions to explore effects of the microbiome on intestine and brain pathophysiology

Total Cost €

EC-Contrib. €

Partnership

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IMBIBE project word cloud

Explore the words cloud of the IMBIBE project. It provides you a very rough idea of what is the project "IMBIBE" about.

stress brain animal function sole turn benefit culture science engineering refinement organic absorption truly though edge assessing types appears basic gi gut decade immunity appropriate phenotypes viability microbiota singularly replaced platform interactions disease microbes iterative situation pressure unquestionable obesity host models barrier asd tract capture pace linked disorder intestinal imbibe vitro microbe improvements trillion replacement crohn pathophysiology spectrum throughput relevance metabolism cutting questioned materials complete health colorectal gastrointestinal energy demonstrated cell alternatives electronic time animals anxiety neuropathologies monitoring 3d ethics cancer bacteria nutrient benefitting diabetes transformative human employed alterations accelerated autism microbiome

Project "IMBIBE" data sheet

The following table provides information about the project.

Coordinator	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	1˙992˙578 €
EC max contribution	1˙992˙578 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2016-COG
Funding Scheme	ERC-COG
Starting year	2017
Duration (year-month-day)	from 2017-10-01 to 2022-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	coordinator	1˙992˙578.00

Map

Project objective

The human gut is host to over 100 trillion bacteria that are known to be essential for human health. Intestinal microbes can affect the function of the gastrointestinal (GI) tract, via immunity, nutrient absorption, energy metabolism and intestinal barrier function. Alterations in the microbiome have been linked with many disease phenotypes including colorectal cancer, Crohn’s disease, obesity, diabetes as well as neuropathologies such as autism spectrum disorder (ASD), stress and anxiety. Animal studies remain one of the sole means of assessing the importance of microbiota on development and well-being, however the use of animals to study human systems is increasingly questioned due to ethics, cost and relevance concerns. In vitro models have developed at an accelerated pace in the past decade, benefitting from advances in cell culture (in particular 3D cell culture and use of human cell types), increasing the viability of these systems as alternatives to traditional cell culture methods. This in turn will allow refinement and replacement of animal use. In particular in basic science, or high throughput approaches where animal models are under significant pressure to be replaced, in vitro human models can be singularly appropriate. The development of in vitro models with microbiota has not yet been demonstrated even though the transformative role of the microbiota appears unquestionable. The IMBIBE project will focus on using engineering and materials science approaches to develop complete (i.e. human and microbe) in vitro models to truly capture the human situation. IMBIBE will benefit from cutting edge organic electronic technology which will allow real-time monitoring thus enabling iterative improvements in the models employed. The result from this project will be a platform to study host-microbiome interactions and consequences for pathophysiology, in particular, of the GI tract and brain.

Publications

List of publications.
year	authors and title	journal	last update
2018	Jonathan Rivnay, Sahika Inal, Alberto Salleo, RÃ³isÃn M. Owens, Magnus Berggren, George G. Malliaras Organic electrochemical transistors published pages: 17086, ISSN: 2058-8437, DOI: 10.1038/natrevmats.2017.86	Nature Reviews Materials 3/2	2020-01-16
2018	C. Pitsalidis, M. P. Ferro, D. Iandolo, L. Tzounis, S. Inal, R. M. Owens Transistor in a tube: A route to three-dimensional bioelectronics published pages: eaat4253, ISSN: 2375-2548, DOI: 10.1126/sciadv.aat4253	Science Advances 4/10	2020-01-16

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The information about "IMBIBE" are provided by the European Opendata Portal: CORDIS opendata.