Explore the words cloud of the CSI-Fun project. It provides you a very rough idea of what is the project "CSI-Fun" about.
The following table provides information about the project.
Coordinator |
MEDIZINISCHE UNIVERSITAET WIEN
Organization address contact info |
Coordinator Country | Austria [AT] |
Total cost | 2˙499˙875 € |
EC max contribution | 2˙499˙875 € (100%) |
Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
Code Call | ERC-2016-ADG |
Funding Scheme | ERC-ADG |
Starting year | 2018 |
Duration (year-month-day) | from 2018-06-01 to 2023-05-31 |
Take a look of project's partnership.
# | ||||
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1 | MEDIZINISCHE UNIVERSITAET WIEN | AT (WIEN) | coordinator | 2˙499˙875.00 |
2 | FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III | ES (MADRID) | participant | 0.00 |
Chronic Systemic Inflammation (CSI) resulting from systemic release of inflammatory cytokines and activation of the immune system is responsible for the progression of several debilitating diseases, such as Psoriasis, Arthritis and Cancer. Initially localised diseases can result in CSI with subsequent systemic spread to distant organs, a key patho-physiological phase responsible for major morbidity and even mortality. Despite the importance of CSI, a complete understanding of the molecular mechanisms, signalling pathways and cell types involved, as well as the chronological evolution of the systemic inflammatory response is still elusive. The classical approach to study inflammation has focused on investigating individual cell types or organs in the pathogenesis of a single disease, thereby neglecting important organ cross-talk and systemic interactions. Furthermore, understanding the temporal and spatial kinetics modulating the inflammatory response requires a detailed study of interactions between different immune and non-immune organs at various time points during disease progression in the context of the whole organism. The aim of this research proposal is to substantially advance our understanding of whole organ physiology in relation to systemic inflammation as a cause or/and consequence of disease with the focus on Psoriasis/Joint Diseases and Cancer Cachexia. The goal is to elucidate the molecular mechanisms at the cellular and systemic level, and to decipher endocrine interactions and cross-talks between distant organs. Various model systems ranging from cell cultures to genetically engineered mouse models to human clinical samples will be employed. Genomic, proteomic and metabolomic data will be combined with functional in vivo assessment using mouse models to understand the multi-faceted role of systemic inflammation in chronic human diseases, such as Inflammatory Skin/Joint disease and Cachexia, a deadly systemic manifestation of Cancer.
year | authors and title | journal | last update |
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2018 |
Ana Soler-Cardona, Agnes Forsthuber, Katharina Lipp, Stefanie Ebersberger, Magdalena Heinz, Klaudia Schossleitner, Elisabeth Buchberger, Marion Gröger, Peter Petzelbauer, Christoph Hoeller, Erwin Wagner, Robert Loewe CXCL5 Facilitates Melanoma Cell–Neutrophil Interaction and Lymph Node Metastasis published pages: 1627-1635, ISSN: 0022-202X, DOI: 10.1016/j.jid.2018.01.035 |
Journal of Investigative Dermatology 138/7 | 2020-04-07 |
2018 |
Yubin Luo, Bettina Grötsch, Nicole Hannemann, Maria Jimenez, Natacha Ipseiz, Ozge Uluckan, Nengyu Lin, Georg Schett, Erwin F. Wagner, Aline Bozec Fra-2 Expression in Osteoblasts Regulates Systemic Inflammation and Lung Injury through Osteopontin published pages: , ISSN: 0270-7306, DOI: 10.1128/mcb.00022-18 |
Molecular and Cellular Biology 38/22 | 2020-04-07 |
2019 |
Nuria Gagoâ€Lopez, Liliana F Mellor, Diego MegÃas, Guillermo MartÃnâ€Serrano, Ander Izeta, Francisco Jimenez, Erwin F Wagner Role of bulge epidermal stem cells and TSLP signaling in psoriasis published pages: , ISSN: 1757-4676, DOI: 10.15252/emmm.201910697 |
EMBO Molecular Medicine 11/11 | 2020-04-07 |
2018 |
Markus Linder, Manfred Hecking, Elisabeth Glitzner, Karin Zwerina, Martin Holcmann, Latifa Bakiri, Maria Grazia Ruocco, Jan Tuckermann, Georg Schett, Erwin F. Wagner, Maria Sibilia EGFR controls bone development by negatively regulating mTOR-signaling during osteoblast differentiation published pages: 1094-1106, ISSN: 1350-9047, DOI: 10.1038/s41418-017-0054-7 |
Cell Death & Differentiation 25/6 | 2020-04-07 |
2019 |
Alvaro C. Ucero, Latifa Bakiri, Ben Roediger, Masakatsu Suzuki, Maria Jimenez, Pratyusha Mandal, Paola Braghetta, Paolo Bonaldo, Luis Paz-Ares, Coral Fustero-Torre, Pilar Ximenez-Embun, Ana Isabel Hernandez, Diego Megias, Erwin F. Wagner Fra-2–expressing macrophages promote lung fibrosis published pages: 3293-3309, ISSN: 0021-9738, DOI: 10.1172/jci125366 |
Journal of Clinical Investigation 129/8 | 2020-04-07 |
2019 |
Özge Uluçkan, Maria Jiménez, Ben Roediger, Jakob Schnabl, LucÃa T. DÃez-Córdova, Kevin Troulé, Wolfgang Weninger, Erwin F. Wagner Cutaneous Immune Cell-Microbiota Interactions Are Controlled by Epidermal JunB/AP-1 published pages: 844-859.e3, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2019.09.042 |
Cell Reports 29/4 | 2020-04-07 |
2018 |
Markus Linder, Elisabeth Glitzner, Sriram Srivatsa, Latifa Bakiri, Kazuhiko Matsuoka, Parastoo Shahrouzi, Monika Dumanic, Philipp Novoszel, Thomas Mohr, Oliver Langer, Thomas Wanek, Markus Mitterhauser, Erwin F Wagner, Maria Sibilia EGFR is required for FOSâ€dependent bone tumor development via RSK2/CREB signaling published pages: , ISSN: 1757-4676, DOI: 10.15252/emmm.201809408 |
EMBO Molecular Medicine 10/11 | 2020-04-07 |
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The information about "CSI-FUN" are provided by the European Opendata Portal: CORDIS opendata.