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INSIST SIGNED

IN-Silico trials for treatment of acute Ischemic STroke

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

INSIST project word cloud

Explore the words cloud of the INSIST project. It provides you a very rough idea of what is the project "INSIST" about.

poor experimenting imaging realizing 2500 variety generate data industry start tafia takes modeling treatments disability perspective arterial perfusion effectiveness configuration neurological patients reusable effect thrombolysis pharmacological thrombectomy pharmacy ischemic stroke validate trials death western models deterioration 3rd despite simulate model positioned optimal world insist trial pool clinical multiple safety populations fragmentation 4500 population alteplase combined outcome finalized thrombosis input thrombus validated later simulating modeled laboratories running integrate microvascular stents interaction totaling patient treatment uniquely silico registry options medication device introduction virtual realize histopathological

Project "INSIST" data sheet

The following table provides information about the project.

Coordinator	ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Organization address address: MEIBERGDREEF 15 city: AMSTERDAM postcode: 1105AZ website: www.amc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	https://www.insist-h2020.eu/
Total cost	5˙550˙675 €
EC max contribution	5˙250˙675 € (95%)
Programme	1. H2020-EU.3.1.5. (Methods and data)
Code Call	H2020-SC1-2017-CNECT-2
Funding Scheme	RIA
Starting year	2017
Duration (year-month-day)	from 2017-11-01 to 2021-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Organization address address: MEIBERGDREEF 15 city: AMSTERDAM postcode: 1105AZ website: www.amc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	coordinator	908˙085.00
2	UNIVERSITE DE GENEVE UNIVERSITE DE GENEVE Organization address address: RUE DU GENERAL DUFOUR 24 city: GENEVE postcode: 1211 website: www.unige.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (GENEVE)	participant	771˙975.00
3	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Organization address address: DR MOLEWATERPLEIN 40 city: ROTTERDAM postcode: 3015 GD website: www.erasmusmc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ROTTERDAM)	participant	717˙500.00
4	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Organization address address: WELLINGTON SQUARE UNIVERSITY OFFICES city: OXFORD postcode: OX1 2JD website: www.ox.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (OXFORD)	participant	568˙125.00
5	UNIVERSITEIT VAN AMSTERDAM UNIVERSITEIT VAN AMSTERDAM Organization address address: SPUI 21 city: AMSTERDAM postcode: 1012WX website: www.uva.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	545˙750.00
6	KATHOLIEKE UNIVERSITEIT LEUVEN KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: OUDE MARKT 13 city: LEUVEN postcode: 3000 website: www.kuleuven.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LEUVEN)	participant	462˙500.00
7	NATIONAL UNIVERSITY OF IRELAND GALWAY NATIONAL UNIVERSITY OF IRELAND GALWAY Organization address address: UNIVERSITY ROAD city: Galway postcode: H91 website: www.nuigalway.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (Galway)	participant	425˙365.00
8	NEURAVI LIMITED NEURAVI LIMITED Organization address address: BLOCK 3 BALLYBRIT BUSINESS PARK city: GALWAY postcode: H91 K5YD website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (GALWAY)	participant	416˙275.00
9	POLITECNICO DI MILANO POLITECNICO DI MILANO Organization address address: PIAZZA LEONARDO DA VINCI 32 city: MILANO postcode: 20133 website: www.polimi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	349˙600.00
10	INSTITUT DE RECHERCHES INTERNATIONALES SERVIER INSTITUT DE RECHERCHES INTERNATIONALES SERVIER Organization address address: RUE CARNOT 50 city: SURESNES postcode: 92284 website: www.servier.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (SURESNES)	participant	85˙500.00
11	M.V. LOMONOSOV MOSCOW STATE UNIVERSITY M.V. LOMONOSOV MOSCOW STATE UNIVERSITY Organization address address: LENINSKIE GORY city: MOSCOW postcode: 119992 website: www.msu.ru contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	RU (MOSCOW)	participant	0.00

Map

Project objective

Stroke is the number one cause of disability in the Western world and the 3rd most common cause of death. Despite new treatment options with intra-arterial thrombectomy, still 2 out of 3 patients still have a poor outcome. The main goal of INSIST is to advance treatments of ischemic stroke and its introduction in clinical practice by realizing in silico clinical stroke trials in which stroke and treatment are modeled. We will generate virtual populations of stroke patients, generate and validate in silico models for intra-arterial thrombectomy, thrombosis and thrombolysis, and microvascular perfusion and neurological deterioration after stroke, and integrate the in silico models to realize an in silico clinical stroke trial. We are uniquely positioned by the availability of a large pool of clinical, imaging, histopathological, and outcome data from multiple recently finalized stroke trials, a large registry (totaling 4500 patients), and new trials that will start later this year (totaling 2500 patients). We will build a population model that takes this input to generate virtual populations of stroke patients addressing the wide variety of patient characteristics. We will build on existing and emerging in silico models to validate reusable models for stroke and stroke treatment with a strong interaction with experimenting modeling in laboratories. The in silico models and virtual populations will be combined to simulate clinical trials and validated by simulating and comparing finalized and currently running trials. The in silico models will be used to simulate clinical trials to evaluate effectiveness and safety of novel devices and medication, both for the device as well as the pharmacological industry. For the device industry, we will evaluate the optimal configuration of thrombectomy stents for reduction of thrombus fragmentation. From the perspective of the pharmacy industry, we will simulate the effect of increased TAFIa on the effectiveness of alteplase.

Deliverables

List of deliverables.
Periodic reporting	Documents, reports	2019-09-02 12:14:23
Quality Assurance Plan	Documents, reports	2019-09-02 12:14:23
First report on dissemination, communication and sustainability	Websites, patent fillings, videos etc.	2019-09-02 12:14:23
First report on models for thrombosis and thrombolysis and combined model describing the models and performed experiments	Documents, reports	2019-09-02 12:14:23
Finite element meshes of patient specific clot and vessel geometries	Documents, reports	2019-09-02 12:14:23
First version of a virtual population of stroke patients (Module I)	Other	2019-09-02 12:14:23
Implementation of model of microvascular damage	Documents, reports	2019-09-02 12:14:23
Initial report on dissemination, exploitation and sustainability plan	Documents, reports	2019-09-02 12:14:23
Project Handbook	Documents, reports	2019-09-02 12:14:23
An in silico clinical stroke trial computing environment	Documents, reports	2019-09-02 12:14:23
Data Management Plan template	Documents, reports	2019-09-02 12:14:23
Consortium Agreement	Documents, reports	2019-09-02 12:14:23

Take a look to the deliverables list in detail: detailed list of INSIST deliverables.

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The information about "INSIST" are provided by the European Opendata Portal: CORDIS opendata.

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