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DeepMiR

Innovative testing of microRNA from liquid biopsies using bistable molecular circuits

Total Cost €

EC-Contrib. €

Partnership

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DeepMiR project word cloud

Explore the words cloud of the DeepMiR project. It provides you a very rough idea of what is the project "DeepMiR" about.

pcr sensitive signals robustness extremely multiplexing class sensibility difficult diagnostic networks quantitative clinically nucleic benefit simplicity programing liquid ultra designing standard cancer for area diseases proof put stream preparation dna diagnostics noise biopsy acids circulating background blood techniques modularity microrna biomarkers detect detection separate robustly molecular dilute

Project "DeepMiR" data sheet

The following table provides information about the project.

Coordinator	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Total cost	149˙852 €
EC max contribution	149˙852 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-PoC
Funding Scheme	ERC-POC
Starting year	2017
Duration (year-month-day)	from 2017-12-01 to 2019-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	coordinator	149˙852.00

Map

Project objective

We are designing molecular networks - based on DNA programing- to detect extremely dilute molecular signals and robustly separate them from background noise. This could have relevant applications in the field of molecular diagnostics, in particular in the area of ultra-sensitive testing of nucleic acids from liquid biopsy for example for the detection of circulating microRNA. MicroRNA are difficult targets for standard ultra sensitive techniques such as quantitative PCR, but, because of their presence in the blood stream, they also represent an emerging class of important biomarkers for a wide range of diseases, including cancer. This project will allow us to put together a proof of principle, based of clinically relevant targets and sample, that will clearly demonstrate the benefit of our approach for the molecular diagnostic of microRNA, in terms of sensibility, multiplexing, robustness, modularity and simplicity in sample preparation.

Publications

List of publications.
year	authors and title	journal	last update
2019	Guillaume Gines, Roberta Menezes, Kaori Nara, Anne-Sophie Kirstetter, ValÃ©rie Taly, Yannick Rondelez Isothermal digital detection of microRNA using background-free molecular circuit published pages: , ISSN: , DOI: 10.1101/701276	BioArXiv	2020-01-30

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The information about "DEEPMIR" are provided by the European Opendata Portal: CORDIS opendata.