DANHIMC SIGNED
Development and Application of Novel Hydrogenase-Inspired Mn Complexes
Total Cost €
0EC-Contrib. €
0Partnership
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Project "DANHIMC" data sheet
The following table provides information about the project.
| Coordinator |
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Organization address contact info |
| Coordinator Country | Switzerland [CH] |
| Total cost | 187˙419 € |
| EC max contribution | 187˙419 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2017 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2018 |
| Duration (year-month-day) | from 2018-03-01 to 2020-02-29 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE | CH (LAUSANNE) | coordinator | 187˙419.00 |
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Project objective
Catalytic hydrogenation reactions have many important applications in the synthesis of chemicals, pharmaceuticals, and fuels. However, currently most catalytic hydrogenation systems rely on catalysts that contain rare and precious late transition metals. [Fe]-hydrogenase is an enzyme considered as an efficient catalyst for hydrogenation reactions. Though various Fe-based synthetic mimics of the active site of [Fe]-hydrogenase have been synthesized, only one of them was reported to activate H2. Recent studies have revealed the great potential of Mn as hydrogenation catalysts. Here we propose to combine the active site of [Fe]-hydrogenase with Mn metal and develop a novel class of Mn complexes. Complex design and synthesis, structure-function study, hydrogenation methodology development and reconstitution of [Mn]-hydrogenase for biochemistry study are the main objectives of this proposal. This work will result in not only new fundamental understanding of base metal catalysis, but also industrially relevant catalysts.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Hui-Jie Pan, Gangfeng Huang, Matthew D. Wodrich, Farzaneh Fadaei Tirani, Kenichi Ataka, Seigo Shima, Xile Hu A catalytically active [Mn]-hydrogenase incorporating a non-native metal cofactor published pages: 669-675, ISSN: 1755-4330, DOI: 10.1038/s41557-019-0266-1 |
Nature Chemistry 11/7 | 2020-04-01 |
| 2020 |
Huiâ€Jie Pan, Xile Hu Biomimetic Hydrogenation Catalyzed by a Manganese Model of [Fe]â€Hydrogenase published pages: 4942-4946, ISSN: 1433-7851, DOI: 10.1002/anie.201914377 |
Angewandte Chemie International Edition 59/12 | 2020-04-01 |
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