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SoftNanoHybrid SIGNED

Polymer-Nanoparticle co-assembly for drug targeting and release kinetics: Investigation on Structure, Morphology, Responsiveness, and Nanoparticle distribution

Total Cost €

EC-Contrib. €

Partnership

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SoftNanoHybrid project word cloud

Explore the words cloud of the SoftNanoHybrid project. It provides you a very rough idea of what is the project "SoftNanoHybrid" about.

functionalization polymer molecules synergistically copolymer rationalize np nanoparticles dispersion magnetic matrix encapsulation nps decisive content precise examine components drug transformations solvent surface aggregates bcp polymeric technique nanohybrids roles correlation 37oc drugs mixed containing active polymers assisted co extremely structures assembly orientation formulated tris concentration shape assembled model characterising anti cancer incorporated profile generate micellar size physical micelles loading doxorubicin dialysis kinetics simultaneous play critical materials buffer morphological release combine characterizing localization functional correlated ph block nanohybrid

Project "SoftNanoHybrid" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY OF BRISTOL Organization address address: BEACON HOUSE QUEENS ROAD city: BRISTOL postcode: BS8 1QU website: www.bristol.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	195˙454 €
EC max contribution	195˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2017
Funding Scheme	MSCA-IF-EF-ST
Starting year	2018
Duration (year-month-day)	from 2018-07-01 to 2020-11-11

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY OF BRISTOL UNIVERSITY OF BRISTOL Organization address address: BEACON HOUSE QUEENS ROAD city: BRISTOL postcode: BS8 1QU website: www.bristol.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BRISTOL)	coordinator	195˙454.00

Map

Project objective

In recent years, co-assembly of nanoparticles (NPs) into block copolymer (BCP) aggregates is emerging as an active field of research, which considers the formation of mixed aggregates that combine synergistically the NP/BCP components to generate novel properties for advanced functional materials and applications. When NPs have been incorporated into the BCP micellar aggregates, various physical parameters e.g. distribution, the content, orientation, and localization of NPs in the polymeric matrix are extremely important, which play decisive roles in determining the characteristics and applications of the NP/BCP nanohybrid.

In this proposal, we aim to investigate the morphological transformations of selected model BCP micelles in the presence of magnetic NPs of different size, shape, concentration and surface functionalization. Simultaneous encapsulation of the drug molecules controlled by the NP distribution and loading will provide critical information on the correlation of drug release with the physical parameters characterizing the polymer nanohybrids. We will also examine how the distribution of NPs within co-assembled structures is correlated with the parameters characterising the polymers and NPs. The drug release kinetics for selected nanohybrid systems will be investigated to rationalize the correlation between precise control of NPs localization/drugs loading with the drug release profile. Doxorubicin (Anti-cancer drug) containing BCP-NP nanohybrid will be formulated by solvent assisted dispersion technique. The drug release kinetics will be investigated by dialysis against tris buffer (pH 7.4/5.0) at 37oC.

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The information about "SOFTNANOHYBRID" are provided by the European Opendata Portal: CORDIS opendata.