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BRONC SIGNED

Behavioral demand-driven dynamic reorganisation of cortical networks revealed by simultaneous wide-field optical imaging and optogenetic stimulation mapping in task-performing mice

Total Cost €

0

EC-Contrib. €

0

Partnership

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 BRONC project word cloud

Explore the words cloud of the BRONC project. It provides you a very rough idea of what is the project "BRONC" about.

host    stimulation    obsessive    stop    imaging    repeating    core    macaque    performing    primate    er    society    integration    observation    contribution    layers    acquire    beneficial    transfers    techniques    mouse    causal    interneurons    technologies    transferred    impacts    local    mapping    dynamic    reorganization    compulsive    laboratory    reorganisation    circuit    indicators    humans    psychophysics    neural    actions    behavior    roles    combine    paradigm    wish    introduction    single    selective    clinical    mice    action    modification    monkey    integrate    human    small    toward    differential    switching    plans    optogenetic    disorders    global    simultaneously    genetically    science    monkeys    point    visualize    circuits    gene    reorganise    calcium    cognitive    functions    mechanism    neuronal    lab    optogenetics    mechanisms    researcher    elucidating    mental    poorly    patients    voltage    optical    psychiatric    memory    plan    brain    suited    cortical    disorder    career    sophisticate    marmoset    encoded    view    networks    neuroscience    spatiotemporal    spatiotemporally    revealed   

Project "BRONC" data sheet

The following table provides information about the project.

Coordinator		 ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Switzerland [CH]
 Total cost 187˙419 €
 EC max contribution 187˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-11-01   to  2020-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 187˙419.00

Map

 Project objective

CAREER PLAN: The Experienced Researcher (ER) has revealed causal neural mechanism of cognitive memory by optogenetics and psychophysics in macaque monkeys. ER wish to combine cognitive neuroscience in monkeys and circuit-based neuroscience in mice to build a new field to study cognitive functions at the level of genetically-defined circuits. Thus, ER plans to develop and acquire new technologies in a top laboratory investigating the mouse brain.

INTRODUCTION: We humans can quickly change what we do. This would require dynamic reorganization of brain networks. Recent studies have revealed differential roles of cortical layers and interneurons in local neuronal circuits. However, a mechanism that reorganise cortical networks to integrate local circuit processing has been poorly understood, while this is a core principle of the brain to work.

OBJECTIVE: Elucidating mechanisms of global integration of local processing from a view point of spatiotemporally-selective causal actions of different cortical layers and interneurons. APPROACH: Spatiotemporal actions of cortical layers and interneurons in task-performing mice will be observed by wide-field optical imaging with genetically-encoded calcium or voltage indicators. Simultaneously, optogenetic stimulation mapping to layers and interneurons will visualize their causal contribution to global processing and task execution. IMPACTS: 1. Mechanisms of dynamic cortical reorganisation for switching behavior have a clinical impact for common psychiatric disorders such as obsessive-compulsive disorder in which patients can not stop repeating a single action. 2. ER transfers knowledge in monkey cognitive science to the host lab to sophisticate mouse paradigm. 3.Techniques developed by ER will be transferred to marmoset, a small non-human primate suited for gene-modification and optical observation. This program is highly beneficial for the society and the career of ER toward understanding of human mental functions.

 Publications

year authors and title journal last update
List of publications.
2019 Johannes M. Mayrhofer, Sami El-Boustani, Georgios Foustoukos, Matthieu Auffret, Keita Tamura, Carl C.H. Petersen
Distinct Contributions of Whisker Sensory Cortex and Tongue-Jaw Motor Cortex in a Goal-Directed Sensorimotor Transformation
published pages: 1034-1043.e5, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2019.07.008 		Neuron 103/6 2019-12-17

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