Opendata, web and dolomites
  1. home
  2. trasparenza
  3. open h2020
  4. bronc

BRONC SIGNED

Behavioral demand-driven dynamic reorganisation of cortical networks revealed by simultaneous wide-field optical imaging and optogenetic stimulation mapping in task-performing mice

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 BRONC project word cloud

Explore the words cloud of the BRONC project. It provides you a very rough idea of what is the project "BRONC" about.

genetically    voltage    mapping    single    wish    view    behavior    spatiotemporal    optogenetics    indicators    visualize    monkey    optical    mechanism    integrate    contribution    functions    revealed    core    host    cognitive    neuroscience    modification    introduction    acquire    clinical    memory    combine    human    neural    simultaneously    integration    networks    encoded    causal    career    roles    switching    brain    transfers    stop    observation    techniques    poorly    disorders    circuits    optogenetic    performing    actions    beneficial    transferred    laboratory    science    researcher    marmoset    plans    neuronal    society    compulsive    paradigm    psychiatric    mechanisms    primate    plan    dynamic    small    selective    stimulation    calcium    suited    layers    disorder    er    point    differential    patients    obsessive    mental    impacts    reorganization    imaging    interneurons    global    cortical    mice    reorganise    technologies    mouse    reorganisation    spatiotemporally    psychophysics    circuit    humans    lab    toward    elucidating    monkeys    action    macaque    sophisticate    gene    local    repeating   

Project "BRONC" data sheet

The following table provides information about the project.

Coordinator		 ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Switzerland [CH]
 Total cost 187˙419 €
 EC max contribution 187˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-11-01   to  2020-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 187˙419.00

Map

 Project objective

CAREER PLAN: The Experienced Researcher (ER) has revealed causal neural mechanism of cognitive memory by optogenetics and psychophysics in macaque monkeys. ER wish to combine cognitive neuroscience in monkeys and circuit-based neuroscience in mice to build a new field to study cognitive functions at the level of genetically-defined circuits. Thus, ER plans to develop and acquire new technologies in a top laboratory investigating the mouse brain.

INTRODUCTION: We humans can quickly change what we do. This would require dynamic reorganization of brain networks. Recent studies have revealed differential roles of cortical layers and interneurons in local neuronal circuits. However, a mechanism that reorganise cortical networks to integrate local circuit processing has been poorly understood, while this is a core principle of the brain to work.

OBJECTIVE: Elucidating mechanisms of global integration of local processing from a view point of spatiotemporally-selective causal actions of different cortical layers and interneurons. APPROACH: Spatiotemporal actions of cortical layers and interneurons in task-performing mice will be observed by wide-field optical imaging with genetically-encoded calcium or voltage indicators. Simultaneously, optogenetic stimulation mapping to layers and interneurons will visualize their causal contribution to global processing and task execution. IMPACTS: 1. Mechanisms of dynamic cortical reorganisation for switching behavior have a clinical impact for common psychiatric disorders such as obsessive-compulsive disorder in which patients can not stop repeating a single action. 2. ER transfers knowledge in monkey cognitive science to the host lab to sophisticate mouse paradigm. 3.Techniques developed by ER will be transferred to marmoset, a small non-human primate suited for gene-modification and optical observation. This program is highly beneficial for the society and the career of ER toward understanding of human mental functions.

 Publications

year authors and title journal last update
List of publications.
2019 Johannes M. Mayrhofer, Sami El-Boustani, Georgios Foustoukos, Matthieu Auffret, Keita Tamura, Carl C.H. Petersen
Distinct Contributions of Whisker Sensory Cortex and Tongue-Jaw Motor Cortex in a Goal-Directed Sensorimotor Transformation
published pages: 1034-1043.e5, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2019.07.008 		Neuron 103/6 2019-12-17

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "BRONC" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "BRONC" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

RipGEESE (2020)

Identifying the ripples of gene regulation evolution in the evolution of gene sequences to determine when animal nervous systems evolved

Read More  

BIOplasma (2019)

Use flexible Tube Micro Plasma (FµTP) for Lipidomics

Read More  

MacMeninges (2019)

Control of Central Nervous Sytem inflammation by meningeal macrophages, and its impairment upon aging

Read More