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BRAIN SIGNED

Bacterial regulation of Apis neurophysiology

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BRAIN project word cloud

Explore the words cloud of the BRAIN project. It provides you a very rough idea of what is the project "BRAIN" about.

traits    predict    neurophysiology    gene    data    metabolites    he    transfer    disciplinary    metabolic    ambitions    phenotypes    groups    investigations    mammalian    organization    bacterial    brain    microbial    social    function    host    diversity    transcriptomics    primary    tracking    symbiosis    exponentially    symbioses    gut    training    symbionts    axis    health    symbiont    interactions    insects    physiological    published    microbiology    cultured    labelling    food    expression    animal    domesticated    manipulation    microbiota    species    apis    area    neurotranscriptomics    behavioural    feasible    sequencing    experimental    previously    tangible    bees    none    mellifera    economic    map    characterization    synergistic    microbiome    benefits    neurological    extended    elusive    hosts    considerable    easily    fish    evolutionary    honeybee    bioinformatics    theory    regions    grown    microbes    realize    molecular    conceptual    inter    secure    think    insemination    biologists    ants    bacteria    understand    microscopy    ecology    ecologist    isotope    little    modifications    genome    harvest   

Project "BRAIN" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE LAUSANNE 

Organization address
address: Quartier Unil-Centre Bâtiment Unicentre
city: LAUSANNE
postcode: 1015
website: www.unil.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 175˙419 €
 EC max contribution 175˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2020-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE LAUSANNE CH (LAUSANNE) coordinator 175˙419.00

Map

 Project objective

Gut microbes are known to affect the neurophysiology of their hosts and genome sequencing now easily allows metabolic characterization of elusive microbial diversity that cannot be cultured. While investigations on the neurological and behavioural consequences of mammalian gut symbionts have grown exponentially in recent years, little is known about the ‘gut microbiota–brain axis’ in insects of major economic interest. The applicant is a molecular evolutionary ecologist who previously used gene expression data to predict physiological modifications in the honeybee after insemination and published a comparative analysis of bacterial symbionts across ants. He now aims to realize an inter-disciplinary program to map the neurological and behavioural extended phenotypes of gut symbionts in bees. Through experimental approaches of microbiome manipulation, neurotranscriptomics, behavioural-tracking, FISH, and isotope-labelling of bacterial metabolites, the project seeks to understand: (i) the extent to which Apis mellifera gut symbionts affect host brain function by identifying the specific bacteria, their metabolic products, and the brain regions involved in host-symbiont interactions, and (ii) assess whether these processes affect behavioural traits relevant for the social organization of bees. None of these objectives have been addressed before and achieving them has high potential to change the way in which biologists think about bacterial symbioses and animal behaviour. The project includes training-through-research for the applicant in microbiology, behavioural ecology, microscopy and bioinformatics, and considerable knowledge transfer in transcriptomics and conceptual symbiosis theory from the applicant to the host groups. Although challenging in its ambitions, the project is synergistic and feasible, and will allow the European Research Area to harvest tangible benefits to improve the health of a domesticated species of primary importance to secure food production.

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The information about "BRAIN" are provided by the European Opendata Portal: CORDIS opendata.

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