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METLINK SIGNED

METLINK: Identification of links between cancer cell growth and metabolism genes.

Total Cost €

EC-Contrib. €

Partnership

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METLINK project word cloud

Explore the words cloud of the METLINK project. It provides you a very rough idea of what is the project "METLINK" about.

single amount imr90 cancer 245 pro screened synthesis nucleotide undiscovered approximately modify karolinska screening cell reactions previously amenable inositol oncogenes treatment amino validated interrogation selective lentiviral heels tricarboxylic happening survival 361 pooled crispr regulation bj human identification throughput mechanisms later acid scilifelab compounds links protein mainly biological carbohydrate library divided elucidate energy 667 initially 355 fibroblasts genes signaling hits metabolic easier entries integration metabolism chain cellular respiratory avenues medium lately 500 tca sub performed oxidations vitamin network 571 pools poorer map 240 vectors achilles actually genetically cycle metlink lipid cas9 druggable libraries enzymatic line

Project "METLINK" data sheet

The following table provides information about the project.

Coordinator	FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III Organization address address: CALLE MELCHOR FERNANDEZ ALMAGRO 3 city: MADRID postcode: 28029 website: www.cnio.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	158˙121 €
EC max contribution	158˙121 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2017
Funding Scheme	MSCA-IF-EF-ST
Starting year	2018
Duration (year-month-day)	from 2018-10-01 to 2020-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III Organization address address: CALLE MELCHOR FERNANDEZ ALMAGRO 3 city: MADRID postcode: 28029 website: www.cnio.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	coordinator	158˙121.00
2	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	0.00

Map

Project objective

Metabolism is crucial for cellular survival. The large amount of evidence covering metabolic entries is mainly about the enzymatic processes and single reactions happening within the metabolic map, but there is poorer understanding of the cellular growth signaling network and regulation around metabolism. With METLINK we aim at identifying new and previously undiscovered selective links between metabolic genes and cellular growth pro-survival mechanisms. The hits will be identified with the use of a pooled libraries of CRISPR/Cas9 lentiviral vectors against metabolic genes and cell cycle/ cancer genes. The metabolic library targets will be divided into sub-pools (carbohydrate metabolism: 245; inositol metabolism and lipid metabolism: 571; tricarboxylic acid (TCA) cycle, respiratory chain, integration energy metabolism: 240; nucleotide metabolism, vitamin synthesis and biological oxidations: 361; amino acid metabolism and protein processing: 667; others: 355) and therefore be amenable to medium-throughput screening and selected metabolic processes interrogation. The cancer/cell cycle genes target will be approximately 500 genes. The screening will be initially performed on the human fibroblasts BJ and IMR90, easier to genetically modify, and later validated in other relevant cancer cell line. This will result in the identification of new Achilles’ heels in cancer within metabolism and propose new druggable targets. They will be validated and screened with a library of compounds actually present at SciLifeLab within Karolinska Institute. Lately this proposal will elucidate potential links between oncogenes or cellular growth genes and metabolic genes providing new avenues for treatment within metabolic reactions.

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The information about "METLINK" are provided by the European Opendata Portal: CORDIS opendata.