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RE-IMMUNE SIGNED

Intelligent Nano-encapsuled siRNA for Restoring Immune Cell Response to Cancer

Total Cost €

0

EC-Contrib. €

0

Partnership

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 RE-IMMUNE project word cloud

Explore the words cloud of the RE-IMMUNE project. It provides you a very rough idea of what is the project "RE-IMMUNE" about.

expert    sirna    biomedicine    naked    site    anti    overcome    action    nanomedicine    therapeutic    complementary    merge    genes    mechanisms    vivo    diversify    protect    acquire    rome    strategies    tor    francesco    thanks    clinicians    nanomaterials    idea    competences    effect    nanodevices    acid    encapsulated    vergata    cancer    caruso    treatment    until    training    sensing    dna    hands    drug    combine    expertise    nucleic    recognition    cutting    time    frank    trafficking    accomplishing    prof    cocktail    immunotherapy    dynamic    re    why    silencing    interdisciplinary    cells    nano    contribution    efficient    intelligent    fundamentally    skills    immune    university    risk    scientific    tumoral    group    backgrounds    tumor    gain    pro    groundbreaking    leads    edge    safe    nanomaterial    intracellular    immunoediting    met    world    drawbacks    foundation    shift    fellowship    microscopy    msc    scientists    nanotechnology    melbourne    combining    independence    synergic    young    nanoscopy    ricci    microenvironment    forefront   

Project "RE-IMMUNE" data sheet

The following table provides information about the project.

Coordinator		 UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA 

Organization address
address: VIA CRACOVIA 50
city: ROMA
postcode: 133
website: www.uniroma2.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Italy [IT]
 Total cost 250˙518 €
 EC max contribution 250˙518 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-GF
 Starting year 2019
 Duration (year-month-day) from 2019-02-18   to  2022-02-17

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA IT (ROMA) coordinator 250˙518.00
2    UNIVERSITY OF MELBOURNE AU (MELBOURNE) partner 0.00

Map

 Project objective

WHY: To effectively bring siRNA-based therapeutic for cancer immunotherapy into the hands of clinicians requires the development of fundamentally new mechanisms to overcome current drawbacks. Accomplishing this will enable more efficient treatment with less side effects. WHAT: RE-IMMUNE is an interdisciplinary programme in which the field of nanomaterial and nucleic acid nanotechnology merge to develop intelligent nano- encapsulated siRNA for safe and efficient delivery of siRNA in cancer-associated immune cells, to re-program and shift the tumor microenvironment from pro to anti-tumoral. To achieve this goal, I will undertake a high risk/high gain programme at the forefront of nanomedicine. The leading idea is to overcome the drawbacks of naked siRNA by combining two synergic strategies that will protect siRNA until recognition of its target site. I will evaluate intracellular trafficking of siRNA nanodevices and the silencing effect. I will also investigate possible synergic effect of a siRNA cocktail able to target different genes at the same time. Finally, I will evaluate the re-immunoediting action in vivo. HOW: The challenge met by the proposed program is to provide a groundbreaking contribution to cancer treatment. To achieve these objectives, I will combine the different scientific backgrounds and expertise of two leading scientists. Prof. Frank Caruso (University of Melbourne) is a world-wide recognized expert on nanomaterials and biomedicine, and Prof. Francesco Ricci (University of Rome Tor Vergata) leads a young and dynamic group at the forefront of DNA nanotechnology for sensing and drug-delivery applications. The fellowship will proceed through a well-defined set of research and training tasks. Thanks to this MSC Fellowship, I will diversify my scientific knowledge and acquire cutting-edge competences (in nanomaterials, microscopy, and nanoscopy), as well as complementary skills, which will become the foundation of my scientific independence.

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The information about "RE-IMMUNE" are provided by the European Opendata Portal: CORDIS opendata.

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