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UCLnProt

De novo design of an UpConverting metalloProtein

Total Cost €

EC-Contrib. €

Partnership

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UCLnProt project word cloud

Explore the words cloud of the UCLnProt project. It provides you a very rough idea of what is the project "UCLnProt" about.

realise distances novo upconversion metalloprotein chemistry complexes lcc synthesis de combination lanthanide complementary ions ln class edge coiled modeling metallopeptide tuneable science binding expertise dr generate full unexplored scratch previously supervisor selectively lccs bioinorganic herein photophysical attractive inorganic interface biology peacock conjunction designed coil computational secondments ligands coils sinha unlocking combine cutting scaffolds time strategy combining first derivatives multimetallic bimetallic upconverting training

Project "UCLnProt" data sheet

The following table provides information about the project.

Coordinator	THE UNIVERSITY OF BIRMINGHAM Organization address address: Edgbaston city: BIRMINGHAM postcode: B15 2TT website: www.bham.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	183˙454 €
EC max contribution	183˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2017
Funding Scheme	MSCA-IF-EF-ST
Starting year	2018
Duration (year-month-day)	from 2018-06-01 to 2020-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE UNIVERSITY OF BIRMINGHAM THE UNIVERSITY OF BIRMINGHAM Organization address address: Edgbaston city: BIRMINGHAM postcode: B15 2TT website: www.bham.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BIRMINGHAM)	coordinator	183˙454.00

Map

Project objective

Herein, we propose to design de novo (“from scratch”) the first upconverting metalloprotein. This will be achieved by exploiting a new class of lanthanide coiled coils (LCC), to generate bimetallic derivatives. These will, for the first time, combine the attractive photophysical properties of Ln complexes, with de novo designed coiled coil scaffolds capable of selectively binding different Ln ions at well-defined and tuneable distances. This programme of work will provide a new strategy for unlocking the full potential of science at the interface of biology and inorganic chemistry, by combining previously unexplored ligands with traditional inorganic complexes, for applications beyond those offered by biology, such as upconversion. The complementary expertise of Dr Sinha (bioinorganic synthesis and computational modeling) and the supervisor Dr Peacock (metallopeptide design) offer the unique combination to realise the full potential of multimetallic LCCs, and will, in conjunction with two planned short secondments, provide Dr Sinha with new and cutting-edge research training.

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The information about "UCLNPROT" are provided by the European Opendata Portal: CORDIS opendata.