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Hypo-RESOLVE SIGNED

Hypoglycaemia - REdefining SOLutions for better liVEs

Total Cost €

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EC-Contrib. €

0

Partnership

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 Hypo-RESOLVE project word cloud

Explore the words cloud of the Hypo-RESOLVE project. It provides you a very rough idea of what is the project "Hypo-RESOLVE" about.

10    hypo    valuable    global    below    answering    input    detected    data    glucose    patients    treatment    barrier    impaired    sustainable    microvascular    event    quantify    events    resolve    lives    diabetic    insulin    million    partnership    cardiovascular    cgm    construct    serious    improves    threshold    chronic    power    impacts    alleviate    decreases    symptoms    psychological    levels    saves    public    risk    line    individual    decline    prevent    complications    patient    mechanisms    huge    populations    restoration    significance    creates    principal    trials    150    diseases    health    explore    constitutes    clinic    hyperglycaemia    life    clinical    reduce    classification    private    epidemiologic    people    diabetes    society    hypoglycaemia    databases    basic    quality    economic    secure    kin    outcomes    prevalent    elevated    altogether    questions    stakeholders    regulators    science    underlying    statistical    prevents    cognitive    poor    whom    normalising    communicable    burden    translational    mortality   

Project "Hypo-RESOLVE" data sheet

The following table provides information about the project.

Coordinator
STICHTING KATHOLIEKE UNIVERSITEIT 

Organization address
address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ
website: www.radboudumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website https://hypo-resolve.eu/
 Total cost 26˙774˙582 €
 EC max contribution 13˙450˙057 € (50%)
 Programme 1. H2020-EU.3.1.7. (Innovative Medicines Initiative 2 (IMI2))
 Code Call H2020-JTI-IMI2-2016-10-two-stage
 Funding Scheme IMI2-RIA
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2022-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) coordinator 2˙301˙983.00
2    THE UNIVERSITY OF SHEFFIELD UK (SHEFFIELD) participant 1˙990˙508.00
3    SYDDANSK UNIVERSITET DK (ODENSE M) participant 1˙354˙981.00
4    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) participant 1˙351˙453.00
5    REGION HOVEDSTADEN DK (HILLEROD) participant 1˙030˙750.00
6    UNIVERSITE DE LAUSANNE CH (LAUSANNE) participant 955˙601.00
7    SIB INSTITUT SUISSE DE BIOINFORMATIQUE CH (GENEVE) participant 934˙250.00
8    MEDIZINISCHE UNIVERSITAT GRAZ AT (GRAZ) participant 800˙000.00
9    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 661˙202.00
10    EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH DE (ST INGBERT) participant 502˙125.00
11    CENTRE HOSPITALIER UNIVERSITAIRE MONTPELLIER FR (MONTPELLIER) participant 465˙000.00
12    UNIVERSITA DEGLI STUDI DI PADOVA IT (PADOVA) participant 392˙687.00
13    UNIVERSITY OF DUNDEE UK (DUNDEE) participant 383˙622.00
14    KING'S COLLEGE LONDON UK (LONDON) participant 325˙891.00
15    ABBOTT DIABETES CARE US (ALAMEDA) participant 0.00
16    Eli Lilly and Company Limited UK (Basingstoke) participant 0.00
17    FEDERATION INTERNATIONALE DU DIABETE BE (BRUXELLES) participant 0.00
18    JDRF INTERNATIONAL US (NEW YORK) participant 0.00
19    MEDTRONIC INTERNATIONAL TRADING SARL CH (TOLOCHENAZ) participant 0.00
20    NOVO NORDISK A/S DK (BAGSVAERD) participant 0.00
21    SANOFI-AVENTIS DEUTSCHLAND GMBH DE (FRANKFURT AM MAIN) participant 0.00
22    THE LEONA M. AND HARRY B. HELMSLEY CHARITABLE TRUST US (NEW YORK) participant 0.00
23    UNITIO INC US (BOSTON) participant 0.00

Map

 Project objective

Diabetes is one of the most prevalent global non-communicable diseases, affecting 60 million people in Europe, 10% of whom with type 1 diabetes. Normalising elevated glucose levels decreases symptoms, prevents microvascular complications, improves cardiovascular health and saves lives, but creates a significant risk for hypoglycaemia when insulin treatment is required. Hypoglycaemia is a serious event associated with cognitive decline, reduced quality of life, cardiovascular events and mortality. Hypoglycaemia remains the principal barrier to achieve glucose levels necessary to prevent diabetic complications of chronic hyperglycaemia. The overall objective of Hypo-RESOLVE is to alleviate the burden and consequences of hypoglycaemia, to be achieved by answering several key questions through a unique public-private partnership. Hypo-RESOLVE will construct secure sustainable databases with data from 100-150 clinical trials offering huge statistical power to establish the glucose threshold(s) below which hypoglycaemia constitutes a risk for poor outcomes in various populations. This will provide valuable input for an evidence based classification of hypoglycaemia to be adopted by regulators, patient organisations and other stakeholders, for application in future trials, the clinic and epidemiologic studies. The basic science and translational research line of Hypo-RESOLVE will advance our understanding on mechanisms underlying consequences of hypoglycaemia and explore novel pathways for the restoration of impaired awareness of hypoglycaemia. Finally, we will determine the significance of CGM-detected low glucose and investigate psychological and economic impacts of hypoglycaemia to quantify the burden of hypoglycaemia both for the individual and next-of-kin, as well as for society. Altogether, Hypo-RESOLVE will importantly further our knowledge of hypoglycaemia, (facilitate to) reduce its burden and contribute to a better life for patients with insulin-treated diabetes

 Deliverables

List of deliverables.
Updated review of the evidence surrounding our proposed classification Documents, reports 2020-02-18 10:16:24
External Project Website Websites, patent fillings, videos etc. 2020-02-18 10:16:25
Hypo-RESOLVE Position Paper Documents, reports 2020-02-18 10:16:25

Take a look to the deliverables list in detail:  detailed list of Hypo-RESOLVE deliverables.

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The information about "HYPO-RESOLVE" are provided by the European Opendata Portal: CORDIS opendata.

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