RadioClick SIGNED

Project "RadioClick" data sheet

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 Partnership

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 Project objective

Diagnosing cancer as early as possible is one of the most powerful strategies in modern medicine to improve human well-being. Antibodies (Abs) are excellent molecules that can be used to target specific tumors. As Abs require hours to days for accumulating on tumor surfaces, the use of Abs for nuclear imaging (such as PET imaging) is limited by the short half-lives of popular radioisotopes. Therefore, we plan to move the step of radiolabeling from the bench to the tumor itself. However, the entanglement of Abs with an artificial chemical probe is one of the most promising but at the same time one of the most technically challenging developmental areas in biotechnology. Our unique approach is based on the production of “hybrid-Abs”, which combine in only one “click” step the power of synthetic chemistry with the best of biology (“custom-biologics”). Our unique selling points are ultra-fast, exceptional bioorthogonal and specific labeling reactions in living organism as well as a both-sided modularity of the connection between Abs and chemical probe. By doing so, high contrast visualization of the cancer will become possible.