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AngioMature SIGNED

Mechanisms of vascular maturation and quiescence during development, homeostasis and aging

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 AngioMature project word cloud

Explore the words cloud of the AngioMature project. It provides you a very rough idea of what is the project "AngioMature" about.

angiomature    layer    adolescence    methylation    maturation    marrow    transcriptional    screen    analyze    map    undergo    expression    brain    previously    aging    mature    types    mechanistic    quiescent    genome    vessel    continuous    endothelial    thereby    functionally    interdisciplinary    human    employ    conditional    create    organotypic    active    lining    newborn    blood    angioarchitectural    sinusoidal    gain    biological    resolution    cells    healthy    pathology    isolated    functional    structural    yield    vessels    transcriptome    mice    vital    ecs    organoid    dna    signaling    omics    ec    culture    unrecognized    organotypically    experimental    angiogenesis    cell    matrix    epigenetic    gene    mechanisms    groundbreaking    sprouting    characterizing    inside    stability    signatures    differentiation    single    biology    bone    lung    vascular    transformative    maintenance    insights    adults    diverse    capillaries    pave    specification    liver    validate    health    differentiated    adult   

Project "AngioMature" data sheet

The following table provides information about the project.

Coordinator
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG 

Organization address
address: SEMINARSTRASSE 2
city: HEIDELBERG
postcode: 69117
website: www.uni-heidelberg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙338˙918 €
 EC max contribution 2˙338˙918 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2023-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG DE (HEIDELBERG) coordinator 1˙275˙000.00
2    DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG DE (HEIDELBERG) participant 1˙063˙918.00

Map

 Project objective

Angiogenesis research has focused on the sprouting of new capillaries. The mechanisms of vessel maturation are much less well understood. Yet, the maintenance of a mature, quiescent, and organotypically-differentiated layer of endothelial cells (ECs) lining the inside of all blood vessels is vital for human health. The goal of ANGIOMATURE is to identify, validate, and implement novel mechanisms of vascular maturation and organotypic EC differentiation that are active during development, maintenance of vascular stability in adults, and undergo changes in aging. We recently identified previously unrecognized gene expression signatures of vascular maturation in a genome-wide screen of ECs isolated from newborn and adult mice. Epigenetic mechanisms were identified that control the EC transcriptome through gain and loss of DNA methylation as well as EC differentiation and signaling specification. These findings pave the way for groundbreaking novel opportunities to study vascular maturation. By characterizing functionally diverse types of blood vessels, including continuous ECs in lung and brain and sinusoidal ECs in liver and bone marrow, the ANGIOMATURE project will (1) determine up to single cell resolution the transcriptional and epigenetic program(s) of vascular maturation and organotypic differentiation during adolescence, (2) analyze the functional consequences of such program(s) in differentiated ECs and their adaptation to challenge, and (3) study changes of maturation and differentiation program(s) and vascular responses during aging. We will towards this end employ an interdisciplinary matrix of approaches involving omics, systems biology, conditional gene targeting, organoid cell culture, and experimental pathology to create a high-resolution structural and functional organotypic angioarchitectural map. The project will thereby yield transformative mechanistic insights into vital biological processes that are most important for human health and healthy aging.

 Publications

year authors and title journal last update
List of publications.
2018 Mahak Singhal, Xiaoting Liu, Donato Inverso, Kai Jiang, Jianing Dai, Hao He, Susanne Bartels, Weiping Li, Ashik Ahmed Abdul Pari, Nicolas Gengenbacher, Eva Besemfelder, Lijian Hui, Hellmut G. Augustin, Junhao Hu
Endothelial cell fitness dictates the source of regenerating liver vasculature
published pages: 2497-2508, ISSN: 0022-1007, DOI: 10.1084/jem.20180008
Journal of Experimental Medicine 215/10 2020-04-04

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