NASCENT SIGNED
Novel Approach to Systematically Characterize Exercise- and Nutrient- responsive genes in Type 2 diabetes and cardiovascular disease
Total Cost €
0EC-Contrib. €
0Partnership
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0NASCENT project word cloud
Explore the words cloud of the NASCENT project. It provides you a very rough idea of what is the project "NASCENT" about.
Project "NASCENT" data sheet
The following table provides information about the project.
| Coordinator |
LUNDS UNIVERSITET
Organization address contact info |
| Coordinator Country | Sweden [SE] |
| Total cost | 1˙875˙000 € |
| EC max contribution | 1˙875˙000 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2015-CoG |
| Funding Scheme | ERC-COG |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-02-01 to 2022-01-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | LUNDS UNIVERSITET | SE (LUND) | coordinator | 1˙875˙000.00 |
Map
Project objective
Proposal summary Type 2 diabetes and cardiovascular disease are devastating and costly morbidities whose prevalences are increasing rapidly around the world. As such, there is an urgent need to develop innovative and effective prevention and treatment strategies. As numerous clinical trials have shown, lifestyle modification is by far the best way to prevent these diseases, with lifestyle being twice as effective as the best drugs, less costly and free from side effects. Yet, human biology is complex, causing some people to respond well and others poorly to the same lifestyle interventions. Thus, a huge, as yet unrealised opportunity exists to optimize the prevention and treatment of cardiometabolic diseases by tailoring lifestyle interventions to the patient’s unique biology. NASCENT is an integrated programme of research through which I will functionally annotate and later translate discoveries of gene-lifestyle interactions made through the interrogation of large epidemiological (N>100,000) datasets at my disposal. The functional annotation of these discoveries will be done using state-of-the-art epigenomic and targeted gene editing tools, whereas the translation of those findings will be achieved using a innovative and powerful clinical trial design that focuses on treatments that are tailored to the participant’s genotype (genotype-based recall). NASCENT capitalizes on a solid foundation of cohorts, methods, and expertise that I have built-up over the past fifteen years, but also exploits state-of-the-art epigenomic and gene-editing technologies that have not previously been used in studies of gene-lifestyle interactions. I expect the integration of these established and new approaches in NASCENT to propel major advances in understanding gene-lifestyle interactions in cardiometabolic disease that help optimise disease prevention.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
Paul W. Franks, Nicholas J. Timpson Genotype-Based Recall Studies in Complex Cardiometabolic Traits published pages: , ISSN: 2574-8300, DOI: 10.1161/CIRCGEN.118.001947 |
Circulation: Genomic and Precision Medicine 11/8 | 2019-04-18 |
| 2016 |
P. W. Franks, M. I. McCarthy Exposing the exposures responsible for type 2 diabetes and obesity published pages: 69-73, ISSN: 0036-8075, DOI: 10.1126/science.aaf5094 |
Science 354/6308 | 2019-04-03 |
| 2017 |
P. W. Franks, N. Atabaki-Pasdar Causal inference in obesity research published pages: 222-232, ISSN: 0954-6820, DOI: 10.1111/joim.12577 |
Journal of Internal Medicine 281/3 | 2019-04-03 |
| 2017 |
Dmitry Shungin, Wei Q. Deng, Tibor V. Varga, Jian\'an Luan, Evelin Mihailov, Andres Metspalu, Andrew P. Morris, Nita G. Forouhi, Cecilia Lindgren, Patrik K. E. Magnusson, Nancy L. Pedersen, Göran Hallmans, Audrey Y. Chu, Anne E. Justice, Mariaelisa Graff, Thomas W. Winkler, Lynda M. Rose, Claudia Langenberg, L. Adrienne Cupples, Paul M. Ridker, Nicholas J. Wareham, Ken K. Ong, Ruth J. F. Loos, Daniel I. Chasman, Erik Ingelsson, Tuomas O. Kilpeläinen, Robert A. Scott, Reedik Mägi, Guillaume Paré, Paul W. Franks Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions published pages: e1006812, ISSN: 1553-7404, DOI: 10.1371/journal.pgen.1006812 |
PLOS Genetics 13/6 | 2019-04-03 |
| 2017 |
Paul W Franks, Alaitz Poveda Lifestyle and precision diabetes medicine: will genomics help optimise the prediction, prevention and treatment of type 2 diabetes through lifestyle therapy? published pages: 784-792, ISSN: 0012-186X, DOI: 10.1007/s00125-017-4207-5 |
Diabetologia 60/5 | 2019-04-04 |
| 2016 |
Naeimeh Atabaki-Pasdar, Mattias Ohlsson, Dmitry Shungin, Azra Kurbasic, Erik Ingelsson, Ewan R. Pearson, Ashfaq Ali, Paul W. Franks Statistical power considerations in genotype-based recall randomized controlled trials published pages: , ISSN: 2045-2322, DOI: 10.1038/srep37307 |
Scientific Reports 6/1 | 2019-04-04 |
| 2018 |
Yan Chen, Angela C. Estampador, Maria Keller, Alaitz Poveda, Jonathan Dalla-Riva, Ingegerd Johansson, Frida Renström, Azra Kurbasic, Paul W. Franks, Tibor V. Varga The combined effects of FADS gene variation and dietary fats in obesity-related traits in a population from the far north of Sweden: the GLACIER Study published pages: , ISSN: 0307-0565, DOI: 10.1038/s41366-018-0112-3 |
International Journal of Obesity | 2019-04-03 |
| 2016 |
Anders Grøntved, Robert W. Koivula, Ingegerd Johansson, Patrik Wennberg, Lars Østergaard, Göran Hallmans, Frida Renström, Paul W. Franks Bicycling to Work and Primordial Prevention of Cardiovascular Risk: A Cohort Study Among Swedish Men and Women published pages: , ISSN: 2047-9980, DOI: 10.1161/JAHA.116.004413 |
Journal of the American Heart Association 5/11 | 2019-04-04 |
| 2016 |
S Ahmad, A Poveda, D Shungin, I Barroso, G Hallmans, F Renström, P W Franks Established BMI-associated genetic variants and their prospective associations with BMI and other cardiometabolic traits: the GLACIER Study published pages: 1346-1352, ISSN: 0307-0565, DOI: 10.1038/ijo.2016.72 |
International Journal of Obesity 40/9 | 2019-04-04 |
| 2018 |
Laura J. Corbin, Vanessa Y. Tan, David A. Hughes, Kaitlin H. Wade, Dirk S. Paul, Katherine E. Tansey, Frances Butcher, Frank Dudbridge, Joanna M. Howson, Momodou W. Jallow, Catherine John, Nathalie Kingston, Cecilia M. Lindgren, Michael O’Donavan, Stephen O’Rahilly, Michael J. Owen, Colin N. A. Palmer, Ewan R. Pearson, Robert A. Scott, David A. van Heel, John Whittaker, Tim Frayling, Martin D. Tobin, Louise V. Wain, George Davey Smith, David M. Evans, Fredrik Karpe, Mark I. McCarthy, John Danesh, Paul W. Franks, Nicholas J. Timpson Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03109-y |
Nature Communications 9/1 | 2019-04-04 |
| 2017 |
Tibor V. Varga, Azra Kurbasic, Mattias Aine, Pontus Eriksson, Ashfaq Ali, George Hindy, Stefan Gustafsson, Jian’an Luan, Dmitry Shungin, Yan Chen, Christina-Alexandra Schulz, Peter M. Nilsson, Göran Hallmans, Inês Barroso, Panos Deloukas, Claudia Langenberg, Robert A. Scott, Nicholas J. Wareham, Lars Lind, Erik Ingelsson, Olle Melander, Marju Orho-Melander, Frida Renström, Paul W. Franks Novel genetic loci associated with long-term deterioration in blood lipid concentrations and coronary artery disease in European adults published pages: dyw245, ISSN: 0300-5771, DOI: 10.1093/ije/dyw245 |
International Journal of Epidemiology | 2019-04-03 |
| 2017 |
Alaitz Poveda, Yan Chen, Anders Brändström, Elisabeth Engberg, Göran Hallmans, Ingegerd Johansson, Frida Renström, Azra Kurbasic, Paul W. Franks The heritable basis of gene–environment interactions in cardiometabolic traits published pages: 442-452, ISSN: 0012-186X, DOI: 10.1007/s00125-016-4184-0 |
Diabetologia 60/3 | 2019-04-03 |
| 2018 |
Hugo Fitipaldi, Mark I. McCarthy, Jose C. Florez, Paul W. Franks A Global Overview of Precision Medicine in Type 2 Diabetes published pages: 1911-1922, ISSN: 0012-1797, DOI: 10.2337/dbi17-0045 |
Diabetes 67/10 | 2019-04-04 |
| 2017 |
Pascal M. Mutie, Giuseppe N. Giordano, Paul W. Franks Lifestyle precision medicine: the next generation in type 2 diabetes prevention? published pages: , ISSN: 1741-7015, DOI: 10.1186/s12916-017-0938-x |
BMC Medicine 15/1 | 2019-04-04 |
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